Preparation method of leptospira interrogans MAP vaccine

A leptospira and vaccine technology, applied in the field of cellular immunity, can solve the problems of high cost, single antigen, poor immune effect, etc., and achieve the effect of good antigenicity and cross-immunity reactivity
CN110478478APending Publication Date: 2019-11-22ZHEJIANG MEDICAL COLLEGE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG MEDICAL COLLEGE
Publication Date
2019-11-22

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Abstract

The invention discloses a dominant T-and B-cell T-B combined multivalent antigen epitope fusion gene and a prokaryotic expression system thereof by constructing leptospira interrogans LipL21, LipL32,groEL and loa22 proteins. The MAP vaccine is prepared by the following steps of: expressing a multiple antigen peptide (MAP) consisting of antigen epitopes, and artificially crosslinking the MAP witha high polymer core carrier. The prepared MAP vaccine is has good immune effect, is low-cost, and is capable of effectively inducing cellular immunity. Toxic and side effects of the vaccine are reduced, safety is improved, and immune pertinence is enhanced.
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Description

technical field

[0001] The invention belongs to the technical field of cellular immunity, and in particular relates to a preparation method of a Leptospira interrogans MAP vaccine. Background technique

[0002] Leptospirosis, which can be caused by pathogenic Leptospira (hereinafter referred to as Leptospira) infection, is an important natural foci of epidemics, zoonotic infectious diseases in the world [2] . Leptospirosis is not only one of the 13 infectious diseases included in the national monitoring and immunization program, but also one of the four infectious diseases that my country focuses on monitoring and epidemic prevention during natural disasters. Vaccination is the most effective and economical means of preventing and controlling infectious diseases. However, Leptospira has the characteristics of many serogroups and types, and there are obvious differences in the dominant prevalent serogroups in different regions, and the cross-protection effect between differ...

Claims

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