Preparation method of 2-(2-bromo-1,3-thiazol-5-yl) acetonitrile

A technology of bromothiazole and thiazole, which is applied in the field of preparation of 2-acetonitrile, achieves the effects of mild reaction conditions, safe and simple preparation process and purification steps, and convenient industrial production
CN110483440AInactive Publication Date: 2019-11-22上海睿升化工科技有限公司
3 Cites 1 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
上海睿升化工科技有限公司
Publication Date
2019-11-22
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
Patent Text Reader

Abstract

The invention discloses a preparation method of 2-(2-bromo-1,3-thiazol-5-yl) acetonitrile, which comprises the following steps: S1) adding a first organic solvent and methyl 2-bromothiazole-4-carboxylate into a reaction flask, cooling the mixture to 0 DEG C, adding sodium borohydride, reacting the mixture at room temperature, performing concentration and extraction, combining organic phases, and performing concentration and column chromatography separation to obtain 2-bromothiazole-5-methanol; S2) adding a second organic solvent and the 2-bromothiazole-5-methanol into a reaction bottle, cooling the mixture to 0 DEG C, adding phosphorus tribromide, washing a product with mother liquor, and performing concentration to obtain 2-bromo-5-bromomethyl-thiazole; S3) adding acetonitrile, the 2-bromo-5-bromomethyl-thiazole, potassium carbonate, tetrabutylammonium fluoride and TMSCN sequentially into a reaction flask, performing extraction, combining organic phases, and performing concentration and recrystallization to obtain the 2-(2-bromo-1,3-thiazol-5-yl) acetonitrile. The preparation method breaks through the blank at home and abroad, the preparation process and purification steps are safe and simple, and the preparation method is suitable for industrial production.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the technical field of compound synthesis, in particular to a preparation method of 2-(2-bromo-1,3-thiazol-5-yl)acetonitrile. Background technique

[0002] Thiazole compounds widely exist in various foods. Since the discovery of the first thiazole compound in the 1960s, its special structure has made thiazole compounds occupy an important position in many fields such as pesticides, pharmacy, biology and material science, so thiazole products have a very wide range of applications. development value. Thiazole compounds are widely used in the field of medicine. The preparation method of a kind of 2-(2-bromo-1,3-thiazol-5-yl)acetonitrile of the present invention has not been reported in domestic and foreign documents at present, and fills the domestic There is no blank for the synthesis of this product. Contents of the invention

[0003] Purpose of the present invention is exactly for the defect existing in the existing ethyl...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More