6-aminomethyl-1,1-dioxo-1,2-benzothiazol-3-one intermediate and synthetic method thereof

A technology of benzothiazole and aminomethyl, which is applied in the field of organic drug synthesis, can solve the problems of low yield and cumbersome synthesis methods, and achieve the effects of high yield, reduced production cost, and mild reaction conditions
CN110483497AActive Publication Date: 2019-11-22ZHENGZHOU INST OF CHIRAL DRUGS RES CO LTD
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
ZHENGZHOU INST OF CHIRAL DRUGS RES CO LTD
Publication Date
2019-11-22

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Abstract

The invention provides a 6-aminomethyl-1,1-dioxo-1,2-benzothiazol-3-one intermediate. The chemical name of the intermediate is 2-(1,1-dioxo-1,2-benzothiazol-3-keto-6-ylmethyl)-1H-isoindole-1,3-dione,and the structural formula of the intermediate is shown in the specification (intermediate 3). The invention further provides a synthetic method of the 6-aminomethyl-1,1-dioxo-1,2-benzothiazol-3-one intermediate. The intermediate 3 provided by the invention provides a novel method and a novel synthetic route for synthesizing a mesosulfuron-methyl intermediate that is 6-aminomethyl-1,1-dioxo-1,2-benzothiazol-3-one. The novel synthetic route does not need hydrogenation reduction reaction, mainly comprises substitution reaction and oxidation reaction, is mild in reaction condition, easily available in various raw materials and high in yield, can effectively reduce the production cost, and has a relatively strong industrial application prospect.
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Description

technical field

[0001] The invention belongs to the field of organic drug synthesis, and specifically relates to a 6-aminomethyl-1,1-dioxo-1,2-benzothiazol-3-one intermediate and a synthesis method thereof. Background technique

[0002] Methsulfuron-methyl, also known as Methsulfuron-methyl, chemical name 2-[(4,6-dimethoxypyrimidine 2-aminocarbonyl) aminosulfonyl]-a-(methylsulfonylamino) p-toluic acid Methyl ester is a new type of sulfonylurea herbicide developed by Bayer AG in 2002. Regarding sulfonylurea herbicides, it is the largest class of herbicides in the world. It mainly works by inhibiting acetolactate synthase , Weed roots and leaves absorb, and conduct in the plant body, thereby prompting weeds to stop growing to achieve the effect of weeding. The agent is mainly used to control gramineous weeds and some broad-leaved weeds in wheat fields, including okra, wild oats, clubhead grass, bluegrass, hardgrass, knotweed, sage grass, wheatgrass, shepherd's purse, sowgrass...

Claims

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