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Refined bear gall powder and application to physique enhancement treatment and prevention of tumors and cancer thereof

A technology of bear bile powder and usage, applied in the field of medicine, can solve the problems of limiting the application range of bear bile powder, many impurities, unstable properties, etc.

Active Publication Date: 2019-12-10
江西天元药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] CN1311002A (00102073.0, Shi Lixia) discloses a refined bear bile powder and a preparation method thereof, which belongs to the field of pharmacy. Common bear bile powder is easy to absorb moisture and agglomerate, has a sticky tooth feeling, extremely fishy smell, extremely bitter taste, many impurities, and slow absorption. The property is unstable and easy to be corrupted, and the content of active ingredients is low, which limits the application range of bear bile powder. Oral application often adds flavoring agents to reduce the stench

Method used

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  • Refined bear gall powder and application to physique enhancement treatment and prevention of tumors and cancer thereof
  • Refined bear gall powder and application to physique enhancement treatment and prevention of tumors and cancer thereof
  • Refined bear gall powder and application to physique enhancement treatment and prevention of tumors and cancer thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0081] Embodiment 1: prepare refined bear bile powder

[0082] (1) the bear bile collected (without tube drainage method) (when it is dried under reduced pressure to obtain powder, measure the content of tauroursodeoxycholic acid and taurochenodeoxycholic acid in this powder, be respectively 22.63% And 16.31%, this data is the percentage content of two kinds of materials in bear bile solids) add water dilution (add 2.5 times of volume water dilutions), filter with 80 mesh screens, 80 mesh screens are filtered gained filtrate and use 1M hydrochloric acid Solution adjusts its pH=3.3, then adds 1.2% sodium chloride in the filtrate, obtains crude bear bile fluid (this crude bear bile fluid is dried under reduced pressure to obtain powder, measure tauroursodeoxycholic acid and taurine angiosperm in this powder The content of deoxycholic acid is 28.47% and 20.33% respectively, which shows that the ratio of the two is basically unchanged before filtration, but it is concentrated du...

Embodiment 2

[0102] Embodiment 2: prepare refined bear bile powder

[0103] Steps (1) to (4) are carried out according to Example 1; in step (5), the ethyl acetate-ether (5:1) mixture used is changed to ethyl acetate, and the precipitate is dried under reduced pressure to remove the solvent to obtain refined Bear bile powder. It was determined that the melting point of the refined bear bile powder was 162-163° C., and the difference in melting point indicated that it had a different crystal form from the refined bear bile powder in Example 1.

Embodiment 3

[0104] Embodiment 3: prepare refined bear bile powder

[0105] Steps (1) to (4) are carried out according to Example 1; in step (5), the ethyl acetate-ether (5:1) mixed solution used is changed to ether, and the precipitate is dried under reduced pressure to remove the solvent to obtain refined bear bile pink. It is determined that the melting point of the refined bear bile powder is 173-175° C., and the difference in melting point shows that it has a different crystal form from the refined bear bile powder in Example 1.

[0106] The results of the above examples 2 and 3 show that in step (5) the ethyl acetate-ether (5:1) mixed solution can be used to obtain the T crystal form with a melting point of 187-189 ° C, instead of using this mixed solution The crystals obtained are different.

[0107]Place 3 months at 45 ℃ of temperature places to embodiment 1~3 gained three kinds of refined bear bile powders, then measure their fusing points, the fusing points of three batches o...

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Abstract

The invention relates to refined bear gall powder and application to physique enhancement treatment and prevention of tumors and cancer thereof, in particular to application of a compound as shown ina formula I as shown in the specification to production of products used for preventing or treating tumors and cancer on one hand. Cu-K alpha radiation is used for the compound, and in a powder X-raydiffraction spectrum expressed in 2theta degrees, diffraction peaks exist at 8.53+ / -0.20 degrees, 10.96+ / -0.20 degrees, 12.03+ / -0.20 degrees, 13.14+ / -0.20 degrees, 14.82+ / -0.20 degrees, 17.26+ / -0.20 degrees, 22.53+ / -0.20 degrees, 24.21+ / -0.20 degrees, 26.68+ / -0.20 degrees, 29.42+ / -0.20 degrees and 31.24+ / -0.20 degrees. The compound shows excellent biological performance, for example, the compoundhas excellent bioavailability, and physiological activity the same as that of bear gall powder or tauroursodeoxycholic acid can be given play to. For example, the compound can be used for preventing or treating tumors and cancer.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a bear bile powder product and a preparation method thereof. The bear bile powder product exhibits excellent biological effects, for example, it can be used for preventing or treating tumors and cancers. Background technique [0002] Bear bile has been used as medicine for more than 1,000 years. It is known as the "gold in medicine" and ranks first among the four major animal medicinal materials: bear bile, tiger bone, bezoar, and musk. At present, there are 153 kinds of Chinese patent medicines made from bear bile powder alone and compound Chinese patent medicine preparations containing bear bile powder, involving 183 drug manufacturers. Its comprehensive effects cannot be replaced by other drugs. Among the 660 classics of traditional Chinese medicine (including more than 80,000 traditional prescriptions) from the Han Dynasty to the Qing Dynasty, about 366 works recorded the ef...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61P35/00C07J41/00C07C277/08C07C279/14
CPCA61K31/575A61P35/00C07J41/0061C07C277/08C07C279/14C07B2200/13
Inventor 傅金荣付金洪
Owner 江西天元药业有限公司
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