Application of beta-NMN in preparation of medicament for treatment and prevention of organ damage caused by sepsis

A technology for organ damage and preventive medicine, applied in the field of biomedicine, can solve the problems that nicotinamide riboside cannot β-nicotinamide mononucleotide, cannot fully reflect the blood sugar situation, and reduce the expression of nicotinamide riboside kinase, etc. The effect of reducing oxidative stress level, increasing NAD+ level and improving cardiac function

Inactive Publication Date: 2019-12-10
SUZHOU UNIV
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current evidence does not support the use of antibiotics within a strict time window for all patients with sepsis, and the overuse of antibiotics will also lead to the increase of drug resistance
[0007] 4. Other adjuvant treatment methods: patients with severe sepsis need to use high-flow nasal cannula or mask oxygen inhalation to protect ventilation to treat respiratory distress and hypoxemia; when the blood glucose level of the patient exceeds 180mg/dl continuously, then Insulin is required, but capillary blood glucose levels detected by bedside indicators do not adequately reflect the patient's plasma and arterial blood glucose
Recent research by the inventor's team confir

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of beta-NMN in preparation of medicament for treatment and prevention of organ damage caused by sepsis
  • Application of beta-NMN in preparation of medicament for treatment and prevention of organ damage caused by sepsis
  • Application of beta-NMN in preparation of medicament for treatment and prevention of organ damage caused by sepsis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1: the preparation of mouse sepsis model

[0046] The following examples of the present invention use the method of intraperitoneal injection of feces to prepare a sepsis mouse model, and the specific method steps are as follows:

[0047] 1. Mice: C57 male mice (about 25 grams in weight) aged 7-8 weeks were placed in the animal turnover room for standby. A number of mice were randomly selected as feces donor mice. Then the remaining mice were randomly divided into four groups: control group, control group plus β-nicotinamide mononucleotide group, feces implantation group and feces implantation plus β-nicotinamide mononucleotide group (the number of each group was more than 5 only).

[0048] 2. Collection of feces: After euthanasia, the donor mice were dissected, and the feces in the cecum were collected and weighed. Every 75 mg of feces was dissolved in 1 ml of normal saline (the volume of implanted feces was 50 ml / kg body weight), and fully mixed for 4 day...

Embodiment 2

[0050] Embodiment 2: β-nicotinamide mononucleotide prevents multiple organ damage in septic mice

[0051] What adopted among the present invention is the administration mode of intraperitoneal injection, and concrete steps are as follows:

[0052] 1. Preparation of β-nicotinamide mononucleotide solution: Weigh the β-nicotinamide mononucleotide required by the experimental mice according to the ratio of 500 mg / kg body weight, and dissolve it in an appropriate amount of normal saline (each mouse The injection volume is 100 μl). For example, when preparing β-nicotinamide mononucleotide injection required for 10 mice weighing 25 grams, 125 mg of β-nicotinamide mononucleotide should be weighed and dissolved in 1 ml of normal saline.

[0053] 2. Intraperitoneal injection of β-nicotinamide mononucleotide: For the implanted feces plus β-nicotinamide mononucleotide group constructed in Example 1, 100 microliters were injected intraperitoneally into the mice while the experimental mice...

Embodiment 3

[0059] Embodiment 3: β-nicotinamide mononucleotide treats multiple organ damage in mice with sepsis

[0060] What adopted among the present invention is the administration mode of intraperitoneal injection, and concrete steps are as follows:

[0061] 1. Preparation of β-nicotinamide mononucleotide solution: Weigh the β-nicotinamide mononucleotide required by the experimental mice according to the ratio of 500 mg / kg body weight, and dissolve it in an appropriate amount of normal saline (each mouse The injection volume is 100 μl). For example, when preparing β-nicotinamide mononucleotide injection required for 10 mice weighing 25 grams, 125 mg of β-nicotinamide mononucleotide should be weighed and dissolved in 1 ml of normal saline.

[0062] 2. Intravenous injection of β-nicotinamide mononucleotide: For the implanted feces plus β-nicotinamide mononucleotide group constructed in Example 1, inject 100 mg into the tail vein of the experimental mice 1 hour after the feces were impl...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to application of beta-nicotinamide mononucleotide (NMN) in the preparation of a medicament for treatment and / or prevention of organ damage caused by sepsis. The invention discloses a novel application of the beta-NMN. The beta-NMN has treatment and prevention protection effects on multiple organ damage caused by sepsis, thereby providing a novel treatment means and a noveltreatment way for diseases in related fields, moreover, the beta-NMN is easily soluble in water, has strong universality and operability, and can be administered in various ways.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of β-NMN in the preparation of medicines for the treatment and prevention of sepsis organ damage. Background technique [0002] Sepsis is a life-threatening multiple organ dysfunction caused by an imbalanced body response after infection, which can develop into septic shock and multiple organ dysfunction syndrome (MODS). One of the leading causes of death among patients. According to reports, there are nearly 18 million sepsis patients in the world every year, and the annual number of sepsis patients in my country is estimated to be more than 5 million, and the number of patients is increasing at a rate of nearly 10% year by year, causing a serious medical burden. The research data of scholars at home and abroad show that despite the continuous progress of "bundle" treatment strategies such as volume assessment and resuscitation, early anti-infection and organ support,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/706A61P31/00A61P9/00A61P11/00A61P1/16A61P13/12
CPCA61K31/706A61P1/16A61P9/00A61P11/00A61P13/12A61P31/00
Inventor 彭天庆曹婷郑东李会丽
Owner SUZHOU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap