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Method for removing impurities in production process of high-purity dihydroartemisinic acid

A dihydroartemisinic acid and production process technology, applied in the separation/purification of carboxylic acid compounds, organic chemistry, etc., can solve problems affecting the purity of dihydroartemisinic acid, reduce impurities, and increase filtration speed.

Inactive Publication Date: 2019-12-13
长沙艾康生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, in the process of extracting dihydroartemisinic acid from waste artemisinin oil, some oily impurities and black colloidal impurities will be produced, which will affect the purity of extracted dihydroartemisinic acid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A method for removing impurities in the production process of high-purity dihydroartemisinic acid, comprising the following steps:

[0036] (1) Extract and let stand: take 100 kg of waste oil without residual solvent used in the production of artemisinin after concentration is complete, its content of dihydroartemisinic acid is 6.9% after testing, and add the dihydroartemisinin acid with a volume concentration of 80% under the condition of stirring 3000L of methanol aqueous solution, which contains sodium hydroxide with a mass volume ratio of 5%, is continuously stirred at room temperature for 8 hours, and left to stand for 4 hours to separate layers;

[0037] (2) Filtration to remove impurities: the upper layer is subjected to coarse filtration and fine filtration, and the lower layer is subjected to centrifugal, coarse filtration and fine filtration respectively to obtain insoluble yellow-white powder. The coarse filtration is centrifugal filtration, and the fine filtr...

Embodiment 2

[0044] A method for removing impurities in the production process of high-purity dihydroartemisinic acid, comprising the following steps:

[0045] (1) Extract and let stand: take 1000kg of waste oil without residual solvent used in the production of artemisinin after concentration is complete, its dihydroartemisinic acid content is 6.9% after testing, add volume concentration under the situation of stirring and be 60% 25000L ethanol aqueous solution, the ethanol aqueous solution contains sodium bicarbonate with a mass volume ratio of 1%, stirring continuously at room temperature for 6h, standing for 2h to separate layers;

[0046] (2) Filtration and impurity removal: the upper layer is subjected to coarse filtration and fine filtration, and the lower layer is subjected to centrifugation, coarse filtration and fine filtration respectively to obtain insoluble yellow-white powder. The coarse filtration is PP cotton core filtration, and the fine filtration is 0.1 -50nm pore size m...

Embodiment 3

[0053] A method for removing impurities in the production process of high-purity dihydroartemisinic acid, comprising the following steps:

[0054] (1) Extract and let stand: take 400g of waste oil without residual solvent used in the production of artemisinin after the concentration is complete, and its content of dihydroartemisinic acid is 6.9% after testing, and add 40% dihydroartemisinin under the condition of stirring Acetone aqueous solution 12000ml, the acetone aqueous solution contains disodium bicarbonate with a mass volume ratio of 0.1%, stirring continuously at room temperature for 4h, standing for 6h to separate layers;

[0055] (2) Filtration of impurities: the upper layer is subjected to coarse filtration and fine filtration, and the lower layer is subjected to centrifugation, coarse filtration and fine filtration respectively to obtain insoluble yellow-white powder. The coarse filtration is plate and frame filtration, and the fine filtration is 0.1- 50nm pore siz...

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Abstract

The invention relates to the field of medicinal chemistry, in particular to a method for removing impurities in the production process of high-purity dihydroartemisinic acid. The method comprises thefollowing steps: (1) extracting and standing; (2) filtering and removing impurities; (3) concentrating; (4) extracting to remove impurities; (5) acidification; (6) extracting, standing and removing impurities; (7) concentration. The method for removing the grease impurities and the black colloidal impurities in the production process of the high-purity dihydroarteannuic acid is low in energy consumption, easy to operate, free of special equipment, small in investment and capable of effectively removing the impurities in the production process of the dihydroarteannuic acid.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to a method for removing impurities in the production process of high-purity dihydroartemisinic acid. Background technique [0002] Artemisinin is a new type of antimalarial drug discovered by Mr. Tu Youyou, a famous Chinese pharmacist and winner of the 2015 Nobel Prize in Medicine, which has the advantages of "high efficiency, quick action, and low toxicity". It has special effects. From 1973 when artemisinin was discovered to 2018, in the past few decades, artemisinin and artemisinin derivatives have developed into a large industry with an annual output value of 1.5 billion US dollars, and the price of artemisinin In 2012, the price peaked at 5,800 yuan per kilogram in recent years and then fell all the way to 950 yuan per kilogram in 2016. From 2016 to 2018, the price of artemisinin has been at 950-1200 yuan per kilogram for two years. The price range of artemisinin makes most...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/42C07C57/26
CPCC07C51/42C07C2602/10C07C57/26
Inventor 廖书桥彭国平欧阳斌
Owner 长沙艾康生物科技有限公司
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