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Turn-on type fluorescent probe for rapidly detecting sulfite(bisulfite)as well as synthesis method and application of turn-on type fluorescent probe

A technology of fluorescent probes and synthetic methods, applied in the directions of fluorescence/phosphorescence, chemical instruments and methods, luminescent materials, etc., can solve problems such as patent publications that have not yet been found, and achieve extremely easy practical promotion and application, simple molecular structure, and synthetic methods easy effect

Active Publication Date: 2019-12-13
TIANJIN UNIVERSITY OF TECHNOLOGY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Through the search, no patent publications related to the patent application of the present invention have been found

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  • Turn-on type fluorescent probe for rapidly detecting sulfite(bisulfite)as well as synthesis method and application of turn-on type fluorescent probe
  • Turn-on type fluorescent probe for rapidly detecting sulfite(bisulfite)as well as synthesis method and application of turn-on type fluorescent probe
  • Turn-on type fluorescent probe for rapidly detecting sulfite(bisulfite)as well as synthesis method and application of turn-on type fluorescent probe

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Embodiment Construction

[0028] The embodiments of the present invention will be described in detail below. It should be noted that the embodiments are illustrative, not restrictive, and cannot limit the protection scope of the present invention.

[0029] The raw materials used in the present invention, unless otherwise specified, are conventional commercially available products; the methods used in the present invention, unless otherwise specified, are conventional methods in the art.

[0030] A turn-on type fluorescent probe CISD for rapid detection of sulfite (hydrogen) salt, the molecular formula of the fluorescent probe is: C 21+n h 15+m N 1+x o 3+y , where n, m, x, y are all integers from 1 to 20, and the molecule has the following structure:

[0031]

[0032] where substituent R 1 It is one of H, alkyl, aryl, nitro, ester, ether and diethylamine, and n in the 3-indole carboxaldehyde derivative is an integer of 1-20.

[0033] A kind of synthetic method of the turn-on type fluorescent pro...

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Abstract

The invention relates to a turn-on type fluorescent probe for rapidly detecting sulfite(bisulfite). The molecular formula of the fluorescent probe is C21 + nH15 + mN1 + xO3 + y, wherein n, m, x and yare all integers from 1 to 20, and the molecule has the following structure: substituent R1 is one of H, alkyl, aryl, nitryl, ester group, ether group and diethylamino, and n in the 3-indolecarboxaldehyde derivative is an integer from 1 to 20. The fluorescent probe is short in response time(10 seconds), high in measurement sensitivity, simple in molecular structure and simple and convenient in synthesis method, and can be used for cell imaging and detection of sulfite(bisulfite)in food and traditional Chinese medicinal materials, so that the fluorescent probe is extremely easy to popularize and apply practically.

Description

technical field [0001] The invention belongs to the technical field of chemical analysis and detection, in particular to a turn-on type fluorescent probe for rapid detection of sulfite (hydrogen) salt, a synthesis method and an application. Background technique [0002] Sulfur dioxide (SO 2 ) has long been recognized as an environmental pollutant harmful to humans and is the main cause of "acid rain" worldwide. Its main sources are volcanic eruptions and burning of sulfur-based fossil fuels. SO 2 After inhalation into the human body, mainly SO 2 Derivatives - exist in the form of sulfite (hydrogen) salt. Sulfite (hydrogen) salt can also be used as a food additive, but excessive intake will lead to adverse reactions such as hypotension, diarrhea, urticaria, etc. Toxicology and epidemiological studies have proved that the abnormal concentration of endogenous sulfite (hydrogen) is closely related to various diseases, such as respiratory system diseases, nervous system dise...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D405/06C09K11/06G01N21/64
CPCC07D405/06C09K11/06G01N21/643G01N21/6428C09K2211/1088C09K2211/1029G01N2021/6417
Inventor 王红颖周要根刘聪聪
Owner TIANJIN UNIVERSITY OF TECHNOLOGY
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