18 results about "Indolecarboxaldehyde" patented technology

The invention discloses a metabolite for treating sarcopenia and application of the metabolite in a health-care product additive, and belongs to the technical field of biomedicine, and the application comprises application of indole-3-formaldehyde in preparation of a medicine for treating sarcopenia. The invention further discloses a health care product additive and a medicine for treating sarcopenia, wherein the medicine comprises indole-3-formaldehyde. According to the present invention, the indole-3-formaldehyde can be adopted as the health product additive or the effective component in the drug, can be used for treating sarcopenia, and can recover the skeletal muscle cell mitochondrial homeostasis so as to improve the muscle cell mitochondrial function index.

The present application mainly relates to a kind of a-karoline derivatives and its synthesis method, under the action of iodine reagent and organic solvent, with indole-3-formaldehyde compound, inorganic ammonium salt, alkyne and other simple and easily obtained raw materials one-step synthesis a-karoline derivatives technical scheme;It overcomes the problems in the prior art a-karoline derivatives synthesis method, such as the need to use expensive metal catalyst, or complex synthesis process, or the need to use high-activity complex reaction substrate etc.It is worth mentioning that the present application can be applied to gram-scale one-step synthesis of a-karoline compound containing antitumor activity.The present application greatly maintains atomic economy;With simple reaction system, high selectivity, low raw material cost and easy to obtain, less reaction equipment, simple experimental operation, high yield, high product utilization value, potential application value in the field of medicine.

The application discloses a fermented Lactobacillus mui J0273, which is preserved in the Guangdong Microbial Culture Collection Center on March 28, 2024, and has a preservation number of GDMCC No: 64463; the fermented Lactobacillus mui J0273 provided by the application has antioxidant activity, can produce indole-3-methanol, and has good DPPH free radical clearance rate, hydroxyl radical clearance rate, high reducing power, Fe 2+ Chelating capacity, can enhance the antioxidant capacity of the host, regulate the host immune, protect the intestinal barrier, and relieve inflammation.

The present disclosure is directed to a method of treating a CTLA-4 checkpoint associated immunodeficiency by administering a therapeutically effective amount of a pharmaceutical composition comprising 1H-indole-3-carboxaldehyde (3-IAld) or 1-methylindole-3-carboxylic acid.

The invention discloses a method for constructing a near-infrared first-zone boron-dipyrromethene dye conjugate through a Knoevenagel condensation reaction and a preparation method of the near-infrared first-zone boron-dipyrromethene dye conjugate. According to the method, 5, 5-difluoro-1, 3, 7, 9-tetramethyl-10-(trifluoromethyl)-5H-4 lambda, 5 lambda-dipyrrolo [1, 2-c: 2 ', 1'-f] [1, 3, 2] diazaborocyclohexane meso-CF3-BODIPY is taken as a raw material, 5-hydroxyindole-3-formaldehyde or 3-indoleformaldehyde or 6-hydroxyindole-3-formaldehyde is taken as a reactant, acetic acid and piperidine are taken as catalysts, and 1, 4 dioxane is taken as a solvent, so that the meso-CF3-BODIPY conjugate is prepared. The method has the advantages of mild reaction conditions, easily available raw materials and excellent yield, and provides a new method for synthesizing the BODIPY conjugate.

The invention mainly relates to the technical field of drug analysis and detection, in particular to an impurity detection method of a compound amino acid injection. High performance liquid chromatography is adopted for detection, and chromatographic conditions are as follows: a chromatographic column adopts octadecylsilane chemically bonded silica as a filler; the wavelength of a UV detector is 210 to 225 nm; mobile phases: a mobile phase A: a sodium dihydrogen phosphate solution with a pH value of 4.0-6.5 and methanol; a mobile phase B: acetonitrile and water; the elution mode is gradient elution; the impurities comprise a tryptophan impurity B, a tryptophan impurity C, a tryptophan impurity D, a tryptophan impurity E, a tryptophan impurity H, a tryptophan impurity G and indole-3-formaldehyde. The detection method disclosed by the invention is good in specificity and high in accuracy; different detection methods do not need to be adopted for separate detection, multiple impurities in the preparation can be detected at the same time, and the detection frequency is reduced; the detection time is shortened and the detection cost is saved; a reliable method is provided for the preparation process of the compound amino acid injection and the quality control of the product, and the medication safety of a patient is improved.

The application discloses a detection method of indole-3-methanal in compound amino acid injection, and belongs to the field of analytical chemistry. The detection method adopts high performance liquid chromatography, and the chromatographic conditions include: a chromatographic column with octadecylsilane bonded silica as a filler, isocratic elution with a mobile phase, detection by a UV detector with a detection wavelength of 301-311 nm, a flow rate of the mobile phase of 0.6-1.0 mL / min, a sample injection amount of 50-150 muL, a column temperature of 30-40 DEG C, and a mobile phase of a mixed solution of acetonitrile and phosphate buffer solution. The application selects the proportion of the mobile phase, pH, flow rate, column temperature, wavelength and sample injection amount and other chromatographic conditions in the light of the low response and small polarity of the impurity by using high performance liquid chromatography, and the method is verified systematically, and has the advantages of strong specificity, high sensitivity, good precision, strong durability and the like, and can qualitatively or quantitatively detect indole-3-methanal in the compound amino acid injection, so that the effectiveness and safety of the related products are improved.

The application provides a pretreatment method and a detection method of indole substances in aquatic products, and relates to the technical field of analysis and detection. The application extracts the aquatic products to be measured by using formic acid-acetonitrile aqueous solution as an extractant, can realize the simultaneous and efficient extraction of six indole substances, i.e. indole, 3-indole acetic acid, 3-methyl indole, indole-3-methyl aldehyde, indole-4-methyl aldehyde and indole-5-methyl aldehyde; the HLB solid phase extraction purification can significantly reduce the amount of impurities in the sample liquid to be measured, and improve the accuracy of the detection result of the subsequent high performance liquid chromatography tandem mass spectrometry. The application adopts the high performance liquid chromatography tandem mass spectrometry detection and the APCI ion source, and the detection result is high in accuracy and sensitivity. Moreover, the detection method provided by the application realizes the high sensitivity detection of the six indole substances, is comprehensive in detection indexes, and can provide the basis for the rapid evaluation of the quality of the aquatic products under the cold storage condition according to the change trend of the total content of the six indole substances.

The invention discloses a method for detecting indole-3-formaldehyde in a compound amino acid injection, and belongs to the field of analytical chemistry. The detection method adopts a high performance liquid chromatography, and the chromatographic conditions are as follows: octadecylsilane chemically bonded silica is used as a chromatographic column of a filler, a mobile phase is used for isocratic elution, an ultraviolet detector is used for detection, the detection wavelength is 301-311nm, the flow rate of the mobile phase is 0.6-1.0 mL / min, the sample size is 50-150mu L, the column temperature is 30-40 DEG C, and the mobile phase is a mixed solution of acetonitrile and a phosphate buffer solution. According to the present invention, by using the high performance liquid chromatography, combining the characteristics of low impurity response and small polarity, the chromatographic conditions such as the mobile phase ratio, the pH value, the flow rate, the column temperature, the wavelength, the sample injection amount and the like are pertinently selected, and the systematic methodology verification results show that the advantages of strong specificity, high sensitivity, good precision, strong durability and the like are provided; the indole-3-formaldehyde in the compound amino acid injection can be qualitatively or quantitatively detected, so that the effectiveness and safety of related products are improved.

The invention discloses application of indole-3-formaldehyde in preparation of a product for treating type-2 diabetes mellitus complicated with metabolic dysfunction related steatohepatitis, and belongs to the technical field of biological medicine. According to the application disclosed by the invention, a T2DM-MASH mouse model is successfully established, not only is the effect of the type 2 diabetes mellitus in acceleration of MASLD fibrosis progress proved, but also a dual treatment mechanism of indole-3-formaldehyde (3-IAld) on the type 2 diabetes mellitus complicated with metabolic dysfunction related steatohepatitis is clarified for the first time; meanwhile, SIRT1 is activated to inhibit a TGF-beta / SMAD signal channel, so that the effect of treating type-2 diabetes mellitus complicated with metabolic dysfunction related steatohepatitis is achieved. These findings provide new therapeutic targets and strategies for the treatment of type-2 diabetes mellitus complicated with metabolic dysfunction related steatohepatitis.

The invention discloses an indole-fused 3-thiopyrazolo[1,5-a]pyrimidine compound, a synthesis method, and an application thereof. The synthesis method of the indole-fused 3-thiopyrazolo[1,5-a]pyrimidine compound comprises the following steps: mixing a 3-indole formaldehyde compound, a 3-aminopyrazole compound, a disulfide, and an iodine-containing additive in a solvent for reaction to obtain an indole-fused 3-thiopyrazolo[1,5-a]pyrimidine compound. The present invention uses a 3-aminopyrazole compound, an aromatic aldehyde derivative, and a thioether as starting materials to prepare the indole-fused 3-thiopyrazolo[1,5-a]pyrimidine compound in one pot. The reaction conditions are mild, the raw materials are cheap and readily available, and the operation is simple, which can significantly reduce production costs and improve production safety. The indole-fused 3-thiopyrazolo[1,5-a]pyrimidine compound has good anti-tumor properties.

The invention belongs to the field of extraction of active ingredients, and particularly relates to a preparation method for separating an anti-vascular endothelial injury active ingredient in spina gleditsiae based on high-speed counter-current chromatography, the obtained active ingredient and application. The method comprises the following steps: (1) taking spina gleditsiae, and adding ethanol for cold soaking to obtain a crude extract; (2) sequentially extracting the crude extract with a solvent to obtain a chloroform extract; and (3) carrying out high-speed counter-current chromatography on the chloroform extract to prepare compounds 1-4 at one time. According to the preparation method provided by the invention, the indole-3-formaldehyde, the (-)-syringol, the 4, 5-dihydroxybenzenol and the omega-hydroxypropylguaiacol can be obtained through large-scale, efficient and rapid purification; and the mobile phase and the stationary phase in the preparation process can be repeatedly utilized, so that the preparation cost is saved.

The invention discloses a synthetic method for direct diarylation of indole C2 and C4 positions, and relates to the technical field of chemical organic synthesis. The invention discloses a synthesis method of a 10-phenylbenzo [4, 5] isothiazolo [2, 3-a] indole-5, 5-dioxide compound, which comprises the following steps: in the presence of a transition metal catalyst, an organic catalyst, an oxidizing agent and acid, taking indole-3-formaldehyde protected by aryl sulfonyl and aromatic hydrocarbon as raw materials, and synthesizing the 10-phenylbenzo [4, 5] isothiazolo [2, 3-a] indole-5, 5-dioxide compound through one-step reaction. The reaction operation is simple, the synthesis steps are short, and synthesis only needs one-time operation. The invention solves the problems of more reaction steps, high cost and poor selectivity of the existing synthesis method of the arylated indole derivative.

The invention relates to an indole oxazole derivative as well as a preparation method and application thereof. Indole-3-formaldehyde is used as a raw material, benzenesulfonyl chloride is used for activating carboxyl, then Van Lensen reaction is carried out to synthesize an oxazole ring, and nucleophilic substitution reaction is carried out to synthesize a series of indole oxazole derivatives. The synthesis method is simple, and the product is high in yield and purity. The compound has good inhibition effects on pyricularia oryzae, botrytis cinerea, colletotrichum capsici, rhizoctonia solani, fusarium graminearum and sclerotinia sclerotiorum, and has a good agricultural application prospect.

This invention discloses a non-heavy atom near-infrared two-photon photosensitive dye, TMBDP, its preparation method, and its applications. This TMBDP photosensitive dye contains no heavy atoms, possesses a fluoroboron dipyrrole dimer structure and two-photon absorption properties, and can simultaneously generate singlet oxygen and superoxide anion radicals through a spin vibrational coupling mechanism. The non-heavy atom two-photon photosensitive dye TMBDP is prepared from triphenylamine fluoroboron dipyrrole dimer and 1-(2-morpholinoethyl)-1H-indole-3-carboxaldehyde via a multi-step tandem reaction. Under near-infrared laser excitation, the non-heavy atom two-photon photosensitive dye TMBDP effectively releases reactive oxygen species through two-photon absorption, promoting tumor cell apoptosis through oxidative damage. As a high-performance near-infrared non-heavy atom two-photon photosensitive dye, it has wide applications in two-photon photodynamic therapy, two-photon fluorescence imaging, and two-photon fluorescence labeling.

The invention discloses an anti-wrinkle non-ironing fabric and a preparation method thereof, and relates to the technical field of fabrics. When the anti-wrinkle non-ironing fabric is prepared, the viscose fabric reacts with the ultraviolet absorbent and the epoxy chloropropane and then reacts with the flame retardant to prepare the pre-modified fabric; the preparation method comprises the following steps: carrying out a reaction on 3-indole formaldehyde and 3-amino-1, 5-pentanediol to prepare indolyl diol; the preparation method comprises the following steps: reacting indolyl glycol, polytetrahydrofuran glycol, 2, 2-dimethylolpropionic acid and isophorone diisocyanate, and then reacting with triethylamine to prepare a polyurethane emulsion; preparing a waterborne polyurethane finishing liquid from the polyurethane emulsion and sodium chloride; the pre-modified fabric and the waterborne polyurethane finishing liquid are subjected to a reaction, and the anti-wrinkle non-ironing fabric is prepared. The anti-wrinkle non-ironing fabric prepared by the invention has excellent anti-ultraviolet, flame-retardant, anti-wrinkle and tensile properties.

The invention provides a method for synthesizing a lignin-based carbazole derivative by a one-pot two-step method, and belongs to the technical field of compound synthesis. The method comprises the following steps: step 1, taking a lignin beta-O-4 model compound and an N-methyl-3-indole formaldehyde compound as reaction raw materials, and reacting for a certain time in a solvent under the action of alkali; and 2, adding acetic acid, a Fe-based catalyst, 2, 2, 6, 6-tetramethylpiperidine oxide, a 4-chlorobutanone compound and an additive into the system, and reacting for a certain time to finally obtain the carbazole compound. The synthetic method for preparing the carbazole derivative has the advantages of being economical, low in cost, simple to operate, mild in reaction condition, high in product selectivity and the like, and a novel green way is provided for preparation of carbazole compounds.

This invention belongs to the field of vegetation restoration technology, and relates to a novel plant growth regulator, specifically a novel plant growth regulator containing an indole structure, its preparation method, and its applications. The plant growth regulator provided by this invention is an indole compound synthesized from o-phenylenediamine and indole-3-carboxaldehyde. By applying regulator solutions of different concentrations, it can promote or inhibit crop growth under different concentration conditions. Furthermore, due to its structural characteristics, IYAA can form a complex with copper, promoting plant growth under copper stress. The regulator preparation method provided by this invention is simple, has significant effects, and has broad application prospects.