4 results about "Indolecarboxaldehyde" patented technology

The present application mainly relates to a kind of a-karoline derivatives and its synthesis method, under the action of iodine reagent and organic solvent, with indole-3-formaldehyde compound, inorganic ammonium salt, alkyne and other simple and easily obtained raw materials one-step synthesis a-karoline derivatives technical scheme;It overcomes the problems in the prior art a-karoline derivatives synthesis method, such as the need to use expensive metal catalyst, or complex synthesis process, or the need to use high-activity complex reaction substrate etc.It is worth mentioning that the present application can be applied to gram-scale one-step synthesis of a-karoline compound containing antitumor activity.The present application greatly maintains atomic economy;With simple reaction system, high selectivity, low raw material cost and easy to obtain, less reaction equipment, simple experimental operation, high yield, high product utilization value, potential application value in the field of medicine.

The application discloses a fermented Lactobacillus mui J0273, which is preserved in the Guangdong Microbial Culture Collection Center on March 28, 2024, and has a preservation number of GDMCC No: 64463; the fermented Lactobacillus mui J0273 provided by the application has antioxidant activity, can produce indole-3-methanol, and has good DPPH free radical clearance rate, hydroxyl radical clearance rate, high reducing power, Fe 2+ Chelating capacity, can enhance the antioxidant capacity of the host, regulate the host immune, protect the intestinal barrier, and relieve inflammation.

The application discloses a detection method of indole-3-methanal in compound amino acid injection, and belongs to the field of analytical chemistry. The detection method adopts high performance liquid chromatography, and the chromatographic conditions include: a chromatographic column with octadecylsilane bonded silica as a filler, isocratic elution with a mobile phase, detection by a UV detector with a detection wavelength of 301-311 nm, a flow rate of the mobile phase of 0.6-1.0 mL / min, a sample injection amount of 50-150 muL, a column temperature of 30-40 DEG C, and a mobile phase of a mixed solution of acetonitrile and phosphate buffer solution. The application selects the proportion of the mobile phase, pH, flow rate, column temperature, wavelength and sample injection amount and other chromatographic conditions in the light of the low response and small polarity of the impurity by using high performance liquid chromatography, and the method is verified systematically, and has the advantages of strong specificity, high sensitivity, good precision, strong durability and the like, and can qualitatively or quantitatively detect indole-3-methanal in the compound amino acid injection, so that the effectiveness and safety of the related products are improved.

The application provides a pretreatment method and a detection method of indole substances in aquatic products, and relates to the technical field of analysis and detection. The application extracts the aquatic products to be measured by using formic acid-acetonitrile aqueous solution as an extractant, can realize the simultaneous and efficient extraction of six indole substances, i.e. indole, 3-indole acetic acid, 3-methyl indole, indole-3-methyl aldehyde, indole-4-methyl aldehyde and indole-5-methyl aldehyde; the HLB solid phase extraction purification can significantly reduce the amount of impurities in the sample liquid to be measured, and improve the accuracy of the detection result of the subsequent high performance liquid chromatography tandem mass spectrometry. The application adopts the high performance liquid chromatography tandem mass spectrometry detection and the APCI ion source, and the detection result is high in accuracy and sensitivity. Moreover, the detection method provided by the application realizes the high sensitivity detection of the six indole substances, is comprehensive in detection indexes, and can provide the basis for the rapid evaluation of the quality of the aquatic products under the cold storage condition according to the change trend of the total content of the six indole substances.