Purine parent-based fluorescent probe compound as well as preparation method and application thereof

A technology of fluorescent probes and compounds, applied in the field of fluorescent probes, can solve problems such as environmental and human health threats, and achieve the effects of easy storage, easy availability of raw materials, and low sensitivity and toxicity

Active Publication Date: 2021-02-09
JIANGSU UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the widespread use of palladium will inevitably pose a great threat to the environment and human health

Method used

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  • Purine parent-based fluorescent probe compound as well as preparation method and application thereof
  • Purine parent-based fluorescent probe compound as well as preparation method and application thereof
  • Purine parent-based fluorescent probe compound as well as preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The fluorescent probe compound based on the purine parent of the present invention is prepared by the following method:

[0044] (1) Preparation of Intermediate I

[0045] Pyrimidine ring parent (1.00g, 3.70mmol), 2-thiophenecarboxylic acid (2.37g, 18.50mmol), phase transfer catalyst DTAC (0.10g, 10%mmol), 25mL POCl 3 and PPA (5.00g, 14.80mmol) were dissolved in xylene; the reaction material was refluxed and stirred at 80°C for 24h. After the reaction was completed, the mixed material was cooled to room temperature and spin-dried to obtain a brown oily substance, which was added to the ice-water mixture, A large amount of solids were precipitated, and the crude product was obtained by suction filtration, and the crude product was purified by silica gel column chromatography, using CH 3 OH / CH 2 Cl 2 (v / v, 1 / 250) elution (the eluent is mixed methanol and dichloromethane according to the volume ratio of 1:250), to obtain intermediate I, which is a light yellow solid (0....

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Abstract

The invention discloses a purine parent-based fluorescent probe compound, and further discloses a preparation method of the fluorescent probe compound and application of the fluorescent probe compoundto detection of palladium ions and copper ions. According to the invention, a purine ring and 3-indolecarboxaldehyde are used as fluorescent groups, hydrazine hydrate is used as a linking group, thepurine parent-based fluorescent probe compound is synthesized, and the obtained fluorescent probe compound has high selectivity and high detection sensitivity on copper and palladium ions, so that thefluorescent probe compound has the advantages of stable structure, good selectivity, high sensitivity and low toxicity; the preparation method is simple in step, raw materials are easy to obtain, andthe obtained product is solid powder and easy to store.

Description

technical field [0001] The invention relates to a fluorescent probe compound based on a purine parent, and also relates to a preparation method of the fluorescent probe compound and an application in detecting palladium ions and copper ions, and belongs to the technical field of fluorescent probes. Background technique [0002] Copper (Cu) is the third most abundant and essential trace element in the human body and plays key roles in various physiological processes such as cellular respiration, brain function and bone formation. However, both its deficiency and overload can lead to several serious diseases such as Alzheimer's disease, Parkinson's disease, Menkes, metabolic disorders and heart disease. On the other hand, palladium, which is one of the platinum group elements (PGE), is widely used in various fields mainly because the catalyst is used in the synthesis of organic molecules and various drugs. However, the widespread use of palladium will inevitably pose a great ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D473/34C09K11/06G01N21/64
CPCC07D473/34C09K11/06G01N21/6428G01N21/6447C09K2211/1074C09K2211/1029C09K2211/1092C09K2211/1011G01N2021/6432G01N2021/6443
Inventor 郑童童李翰林陈葳陆鸿飞
Owner JIANGSU UNIV OF SCI & TECH
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