Preparation method of cortex magnoliae officinalis alcohol extract solid dispersion

Abstract

The present invention provides a preparation method of a cortex magnoliae officinalis alcohol extract solid dispersion. The preparation method comprises the following steps: taking cortex magnoliae officinalis extract freeze-dried powder and a carrier, conducting dissolving in an ethanol solution, conducting rotary evaporation to remove the ethanol solution, and conducting drying and crushing. Thecarrier is composed of polyethylene glycol and poloxamer. The preparation method of the cortex magnoliae officinalis alcohol extract solid dispersion can prepare the cortex magnoliae officinalis alcohol extract solid dispersion with extremely high dissolution, is beneficial to improve total dissolution degrees of main effective ingredients of cortex magnoliae officinalis of magnolol, improves water solubility, increases a utilization rate of the cortex magnoliae officinalis, facilitates further refinement of the cortex magnoliae officinalis related preparations, and expands clinical applications.

Description

technical field [0001] The invention relates to a preparation method of magnolol extract solid dispersion. Background technique [0002] Magnolia officinalis is the dried dry bark, root bark and branch bark of Magnolia officinalis Rehd.et Wils and Magnolia officinalis Rehd.et Wils.var.biloba Rehd.et Wils. Magnolia officinalis bitter in the mouth, pungent, warm in nature. Return spleen, stomach, lung, large intestine channel. It has the functions of drying dampness and eliminating phlegm, removing fullness from descending Qi. For dampness stagnation injury, nausea, vomiting and diarrhea, stagnation of Qi due to food accumulation, abdominal distension and constipation, dyspnea and cough due to phlegm retention. The main active ingredients in magnolia bark, such as magnolol and honokiol, are insoluble in water, and their oral bioavailability is still low, which limits the development of related product preparations and affects clinical application. At present, most of the r...

AI Technical Summary

Problems solved by technology

The main active ingredients in magnolia bark, such as magnolol and honokiol, are insoluble in water, and their oral bioavailability is still low, which limits the development of related product preparations and affects clinical application

At present, most studies focus on improving the dissolution rate of monomer components, ignoring the characteristics of the overall effect of multiple components in traditional Chinese medicine.

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