A kind of fine sugar granule and its preparation method, equipment and application

Abstract

The present invention provides a kind of fine sugar granule, the fine sugar granule has pores inside, and the outside is approximately spherical, and the fine sugar granule is made of pure sucrose and no more than 0.5% glucose syrup powder as raw materials; the fine sugar granule The particle size is 30-100 mesh, the apparent density is 0.4-0.6g / ml, and the angle of repose is 30°-35°. The fine sugar particles have good fluidity, good solubility and good compressibility, and can be used as pharmaceutical excipients for direct tablet compression; the preparation method controls the ratio of the volume of the fluidized bed to the weight of the material, the pressure of the water spray pump and the amount of hot air, the above-mentioned fine sugar granules that can be used for direct compression can be prepared.

Description

technical field [0001] The invention belongs to the field of pharmaceutical excipients, and in particular relates to a fine sugar granule and a preparation method, equipment and application thereof. The fine sugar granule has pores inside and an approximate spherical shape outside. Background technique [0002] Sucrose is an important excipient in pharmaceutical preparations. It can be used as a sweetener and a filler for solid preparation tablets, and it plays the role of flavor correction and excipient. Sucrose is widely used in pharmaceutical preparations. At present, its application forms at home and abroad are as follows Several: [0003] 1. Crystalline sucrose: sucrose crystals, which are used as sweeteners, flavoring agents, fillers, binders, and coating materials for sugar-coated tablets in preparations. When used in tablets, it generally cannot be directly compressed, but needs to be crushed into powdered sucrose for use; [0004] 2. Sucrose powder: The sucrose po...

AI Technical Summary

Problems solved by technology

Ordinary sucrose and crushed sugar powder cannot be directly compressed in one step in the production of tablets, that is, all raw and auxiliary materials are mixed evenly at one time and then compressed. Exist in the original granules in the tablet, which affects the appearance of the tablet and the performance of dissolution and disintegration; and after the sucrose is crushed into powdered sugar, although the dissolution performance is improved, the fluidity of the powdered sugar is very poor, and the mixing is poor. Unable to smoothly unload during tablet production, it is also impossible to compress uniform tablets

[0008] On the other hand, the sucrose products currently available for direct compression, such as compressible sucrose and sucrose spherical particles, all contain at least 2% of non-sucrose components, such as starch, dextrin, etc., because these components cannot be dissolved in water , and the quality requirement of the effervescent tablet preparation is to dissolve into a clear liquid in water, so the above-mentioned directly compressed sucrose products cannot be used in the prescription of effervescent tablets

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