High-stability hemodialysis membrane and preparation method thereof

A hemodialysis, high-stability technology, used in semi-permeable membrane separation, chemical instruments and methods, membranes, etc., can solve problems such as leachables, and achieve the effect of improving mechanical properties, long-term performance retention, and the best overall performance

Inactive Publication Date: 2020-01-03
NANJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Another object of the present invention is to provide a method for preparing a high-stability hemodialysis membrane, not only the preparation process is simpler than the existing process, the whole process does not need to use any additives, and the obtained dialysis membrane has permanent hydrophilicity , has good permeability to small and medium molecular toxins, and fundamentally solves the problem of leachables during the use of hemodialysis membranes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Add 3.4g PSF-b-PEG block copolymer (PEG molecular weight 20kDa, block content is 21wt%) into 16.6g N-methylpyrrolidone solution, stir and dissolve under 60℃ water bath, and then dry it in 60℃ drying oven Leave it to stand still and defoam to obtain a casting liquid with a uniform solid content of 17%. Pour the casting liquid on a clean and smooth glass plate, scrape the film with a scraper of a certain thickness, immerse it in a deionized water coagulation bath after natural volatilization for 10 seconds, and then continue to soak the film in deionized water after the film comes off automatically After 24h, the polysulfone / polyethylene glycol hemodialysis membrane was obtained.

[0037] The pure water flux of the prepared polysulfone / polyethylene glycol hemodialysis membrane was 403L·m- 2 ·H -1 ·Bar -1 , The rejection rate of bovine serum albumin is 78%, the contact angle is 64°, and the adsorption capacity of BSA is 21μg·cm -2 , The hydrophilicity remains unchanged for mo...

Embodiment 2

[0039] Add 3.8g PSF-b-PEG block copolymer (PEG molecular weight 20kDa, block content is 21wt%) into 16.2g N-methylpyrrolidone solution, stir and dissolve in a water bath at 60℃, and then in a drying oven at 60℃ It is allowed to stand still and defoamed to obtain a casting liquid with a uniform solid content of 19%. Pour the casting liquid on a clean and smooth glass plate, scrape the film with a scraper of a certain thickness, immerse it in a deionized water coagulation bath after natural volatilization for 10 seconds, and then continue to soak the film in deionized water after the film comes off automatically After 24h, the polysulfone / polyethylene glycol hemodialysis membrane was obtained.

[0040] The pure water flux of the prepared polysulfone / polyethylene glycol hemodialysis membrane is 264L·m- 2 ·H -1 ·Bar -1 , The rejection rate of bovine serum albumin is 83%, the contact angle is 59°, and the amount of BSA adsorption is 29μg·cm -2 , The hydrophilicity remains unchanged fo...

Embodiment 3

[0042] Add 4.2g PSF-b-PEG block copolymer (PEG molecular weight 20kDa, block content is 21wt%) into 15.8g N-methylpyrrolidone solution, stir to dissolve under 60℃ water bath, and then dry it in 60℃ drying oven It is allowed to stand still and defoamed to obtain a casting liquid with a uniform solid content of 21%. Pour the casting liquid on a clean and smooth glass plate, scrape the film with a scraper of a certain thickness, immerse it in a deionized water coagulation bath after natural volatilization for 10 seconds, and then continue to soak the film in deionized water after the film comes off automatically After 24h, the polysulfone / polyethylene glycol hemodialysis membrane was obtained.

[0043] The pure water flux of the prepared polysulfone / polyethylene glycol hemodialysis membrane is 210L·m- 2 ·H -1 ·Bar -1 , The retention rate of bovine serum albumin is 93%, the contact angle is 64°, and the amount of BSA adsorption is 35μg·cm -2 , The hydrophilicity remains unchanged for...

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Abstract

The invention provides a high-stability hemodialysis membrane. The high-stability hemodialysis membrane is a hemodialysis membrane prepared by preparing a membrane casting solution through only takinga polysulfone-based amphiphilic block copolymer as a membrane forming material and by carrying out a phase inversion process; and the molecular weight of the polysulfone-based amphiphilic block copolymer is 20-240 kDa, wherein a mass ratio of a polysulfone block to a hydrophilic block is 2.4-8.2. The invention also provides a preparation method of the high-stability hemodialysis membrane. The preparation method comprises the following steps: preparing the membrane casting solution from the polysulfone-based amphiphilic block copolymer, and carrying out the solution phase inversion process toprepare a membrane that is the high-stability hemodialysis membrane. The hemodialysis membrane has a good permeability to small and medium molecular toxins, also can completely eradicate dissolution,and has permanent hydrophilicity. The preparation method has a simple process, does not need to use any additive, and fundamentally solves the problem of appearance of dissolved matters in the use process of the hemodialysis membrane.

Description

Technical field [0001] The invention belongs to the technical field of porous material separation membranes, and specifically relates to a hemodialysis membrane and a method for preparing the hemodialysis membrane by using a polysulfone block copolymer. Background technique [0002] Hemodialysis technology is an important way of renal replacement therapy for patients with acute and chronic renal failure. It is the process of draining blood from the body to the body, purifying the blood through a dialyzer, and returning the purified blood. Because of its relatively low cost and low treatment requirements, hemodialysis has been widely used in hemodialysis and blood purification technology. In addition, since it is an in vitro process, it can reduce the occurrence of side effects. In the whole process, the hemodialysis membrane is the most important part. Therefore, a simple and effective method for preparing hemodialysis membranes is extremely important. [0003] Polysulfone is a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/80B01D69/02B01D67/00
CPCB01D67/0011B01D67/0013B01D67/0016B01D69/02B01D71/80B01D2325/24B01D2325/36
Inventor 汪勇钟丁磊
Owner NANJING UNIV OF TECH
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