Novel bio-ink

A bio-ink, a new type of technology, applied in the field of biomedicine, can solve the problems of poor printability, difficult to maintain long-term cell activity, insufficient mechanical strength, etc., and achieve good recovery performance, good modulus and shear thinning, and good mechanics. performance effect

Pending Publication Date: 2020-01-07
安徽骆华生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a new type of bio-ink, which solves the problems of bio-ink extrusion difficulties, poor printability, insufficient mechanical strength, and difficulty in maintaining long-term cell activity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The specific steps of the production method are as follows:

[0026] (1) Prepare according to the composition and weight: 30% acrylate emulsion binder, 37% water-based polyurethane acrylate binder, 15% isopropanol, 2% neutralizer, 2% thickener, collagen 1 %, calcium carbonate 5% and deionized water 8%;

[0027] (2) Add the above-mentioned acrylate emulsion binder, water-based urethane acrylate binder, isopropanol and collagen into the above-mentioned deionized water, stir with a high-speed mixer until it is heated and fully dissolved to obtain a mixed liquid;

[0028] (3) Add the above-mentioned neutralizer, thickener and calcium carbonate into the above-mentioned mixed liquid, fully stir and disperse evenly to obtain the new bio-ink.

Embodiment 2

[0030] The specific steps of the production method are as follows:

[0031] (1) Prepare according to the composition and weight: 35% acrylate emulsion binder, 24% water-based polyurethane acrylate binder, 10% isopropanol, 5% neutralizer, 5% thickener, collagen 3 %, calcium carbonate 8% and deionized water 10%;

[0032] (2) Add the above-mentioned acrylate emulsion binder, water-based urethane acrylate binder, isopropanol and collagen into the above-mentioned deionized water, stir with a high-speed mixer until it is heated and fully dissolved to obtain a mixed liquid;

[0033] (3) Add the above-mentioned neutralizer, thickener and calcium carbonate into the above-mentioned mixed liquid, fully stir and disperse evenly to obtain the new bio-ink.

Embodiment 3

[0035] The specific steps of the production method are as follows:

[0036] (1) Prepare according to the composition and weight: 30% acrylate emulsion binder, 28% water-based polyurethane acrylate binder, 8% isopropanol, 4% neutralizer, 5% thickener, collagen 3 %, calcium carbonate 10% and deionized water 12%;

[0037] (2) Add the above-mentioned acrylate emulsion binder, water-based urethane acrylate binder, isopropanol and collagen into the above-mentioned deionized water, stir with a high-speed mixer until it is heated and fully dissolved to obtain a mixed liquid;

[0038] (3) Add the above-mentioned neutralizer, thickener and calcium carbonate into the above-mentioned mixed liquid, fully stir and disperse evenly to obtain the new bio-ink.

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PUM

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Abstract

The invention discloses a novel bio-ink. The novel bio-ink is prepared from the components by the weight percentage: 30 to 35% of an acrylate emulsion connection material, 20 to 40% of a waterborne polyurethane acrylate connection material, 5 to 15% of isopropanol, 2 to 5% of a neutralizer, 2 to 5% of a thickener, 1 to 3% of collagen, 5 to 10% of calcium carbonate and 8 to 12% of deionized water.The novel bio-ink disclosed by the invention can solve the problems of molding and curing of biological 3D printing ink; with the acrylate emulsion connection material and the waterborne polyurethaneacrylate connection material, the novel bio-ink of the polyurethane aqueous dispersion body has rheological property suitable for 3D printing, has the advantages of good modulus, good shear thinning property and good mechanical property, can respectively resist 50 Pa shear stress after being cured, and has good recovery performance after creep deformation, and the activity of cells inside a scaffold is not affected by the mechanical property of the scaffold.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a novel biological ink. Background technique [0002] In the current biomedical field, the role of tissue engineering is becoming more and more important—by integrating biomaterials (scaffolds), cells and biological factors, it is expected to realize the repair of biological tissues and organs; A three-dimensional structural scaffold that meets certain shape requirements, has characteristics similar to extracellular matrix, and can provide the required biological environment and mechanical support for tissue growth is very important; among the various ways to construct the required three-dimensional scaffolds, biological 3D printing is the most important. potential; compared with other traditional methods, its advantages lie in that it is simple, fast, and easy to meet individual needs in different situations; how to develop a 3D printing machine with good printing performance, stable ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09D11/107C09D11/102C09D11/03C09D11/101B33Y80/00
CPCC09D11/107C09D11/102C09D11/03C09D11/101B33Y80/00
Inventor 苗春光
Owner 安徽骆华生物科技有限公司
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