Composition with skin whitening effect, skin-whitening soluble micro-needle patch with high drug loading capacity, and preparation method of skin-whitening soluble micro-needle patch
A high drug-loading, soluble technology, applied in the field of microneedles, can solve the problems that microneedles cannot pierce the skin, low microneedle strength, and low drug loading, so as to reduce skin pigmentation, resist ultraviolet rays, and achieve excellent whitening skin effect
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[0060] Example 1
[0061] The whitening and soluble microneedle patch with high drug loading provided in this embodiment is composed of a needle tip and a base; the raw material composition of the needle tip is as follows (in parts by weight): 13 parts of arbutin, 15 parts of magnesium ascorbyl phosphate, 7 parts of adenosine, 0.4 parts of sturgeon caviar extract, 106.2 parts of sodium hyaluronate (molecular weight 280kDa), 6 parts of polyvinylpyrrolidone (molecular weight 1300kDa), 12 parts of glycerin, 6 parts of hydroxypropyl cellulose; basic The composition of the raw materials is as follows: 1.1 parts of sodium hyaluronate (molecular weight 280Kda), 0.1 part of glycerin, and 0.1 part of hydroxypropyl cellulose.
[0062] The preparation method of the high-drug whitening soluble microneedle patch provided in this example is as follows:
[0063] S1: Preparation of the needle tip: After mixing the raw materials for preparing the needle tip, add 591.4 parts of distilled water and st...
Example Embodiment
[0065] Example 2
[0066] The whitening and soluble microneedle patch with high drug loading provided in this embodiment is composed of a needle tip and a base; the raw material composition of the needle tip is as follows (in parts by weight): 13 parts of arbutin, 15 parts of magnesium ascorbyl phosphate, 7 parts of adenosine, 0.4 parts of sturgeon caviar extract, 70.8 parts of hyaluronic acid (molecular weight 280kDa), 6 parts of polyvinylpyrrolidone (molecular weight of 1300kDa), 12 parts of glycerin, 6 parts of hydroxypropyl cellulose; base The composition of the raw materials is as follows: 1.1 parts of sodium hyaluronate (molecular weight 280kDa), 0.1 part of glycerin, and 0.1 part of hydroxypropyl cellulose.
[0067] The preparation method of the high-drug whitening soluble microneedle patch provided in this example is as follows:
[0068] S1: Preparation of the needle tip: After mixing the raw materials for preparing the needle tip, add 591.4 parts of distilled water and stir...
Example Embodiment
[0070] Example 3
[0071] The whitening and soluble microneedle patch with high drug loading provided in this embodiment is composed of a needle tip and a base; the raw material composition of the needle tip is as follows (in parts by weight): 13 parts of arbutin, 15 parts of magnesium ascorbyl phosphate, 7 parts of adenosine, 0.4 parts of sturgeon caviar extract, 35.4 parts of hyaluronic acid (molecular weight of 280kDa), 6 parts of polyvinylpyrrolidone (molecular weight of 1300kDa), 12 parts of glycerin, 6 parts of hydroxypropyl cellulose; base material The composition is as follows: 1.1 parts of sodium hyaluronate (molecular weight 280kDa), 0.1 part of glycerin, and 0.1 part of hydroxypropyl cellulose.
[0072] The preparation method of the high-drug whitening soluble microneedle patch provided in this example is as follows:
[0073] S1: Preparation of the needle tip: After mixing the raw materials for preparing the needle tip, add 591.4 parts of distilled water and stir to disso...
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