Chinese thorowax root nano preparation as well as preparation method, detection method and application thereof

Abstract

The invention relates to a Chinese thorowax root nano preparation. The preparation is composed of the following ingredients: 1.00 to 3.01 g of an oil phase, 0.50 to 3.00 g of an aqueous phase, 4.00 to6.76 g of an emulsifier, and 1.76 to 4.51 g of a co-emulsifier. A preparation method of the preparation comprises the following steps: weighing the formulating amount of the emulsifier, co-emulsifierand oil phase, putting the weighed materials in a beaker, performing uniform mixing on a magnetic stirrer at a rotation speed of 500 r / min, weighing the aqueous phase, performing ultrasonic treatmentfor thorough dissolution, slowly adding the solution into the beaker under stirring, uniformly mixing the oil phase and the aqueous phase to obtain a Chinese thorowax root nanoemulsion, and after thenanoemulsion is formed, adding a pharmaceutically acceptable excipient to prepare the pharmaceutically acceptable dosage form. The Chinese thorowax root nanoemulsion is used as a massage medium during massage to treat fever in children, the antipyretic effect is obvious, and the nanoemulsion does not bring discomfort to skin such as redness, swelling and pain, and has low toxic and side effects.

Description

technical field [0001] The invention relates to the field of medical inventions, in particular to a Bupleurum nano-preparation, a preparation method, a detection method and an application. Background technique [0002] Fever is a common acute and severe disease in pediatrics. Axillary body temperature exceeding 37.3°C is considered to be fever. The disease names of children's fever in TCM literature mainly include hot flashes, dysphoria, strong heat, accumulated heat, bone steaming heat, alternating cold and heat, night fever and shock fever. Li Wenlu. Research on the theory of diagnosis and treatment of fever in children based on ancient Chinese literature [D]. Liaoning University of Traditional Chinese Medicine, 2017 The causes of fever in children mainly include exogenous six exogenous factors and internal injuries. , wind-heat, and seasonal temperature-heat cause disease; internal injuries are mainly caused by food accumulation, fetal fever, mistreatment and wrong treat...

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Problems solved by technology

[0007] The above-mentioned patents are mainly oral preparations, which improve the bioavailability of Bupleurum oil, enhance the stability of the drug, delay the pharmacokinetic time of Bupleurum oil in the body, and can effectively avoid the side effects caused by the use of Bupleurum oil injection. Various adverse reactions, but the effect of the above-mentioned invention as a medium in the use of massage therapy for children with fever is not obvious

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