Compounds and compositions for treating hematological disorders

A compound, leukemia technology, applied in drug combinations, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of AML death and low survival rate
CN110691589APending Publication Date: 2020-01-14奥锐金肿瘤有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
奥锐金肿瘤有限公司
Publication Date
2020-01-14

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Abstract

The present invention provides methods for treating hematological disorders, such as acute myeloid leukemia, by the use of substituted heterocyclic compounds and pharmaceutically acceptable salts thereof. The compounds inhibit IRAK4 and FLT-3 kinases.
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Description

[0001] Cross References to Related Applications

[0002] This application claims the benefit of priority from Indian Provisional Patent Application Serial No. 201741011785 filed on March 31, 2017, which is hereby incorporated by reference in its entirety. Background technique

[0003] Acute myeloid leukemia (hereinafter also referred to as "AML") is a hematological malignancy with a poor prognosis, usually occurring in adults, and its 5-year survival rate is estimated to be 20%. Currently, AML therapy temporarily reduces the number of AML cells to levels below the limit of detection. This condition is called a "complete remission." However, AML often relapses after complete remission, and for many patients, relapsed AML leads to death. In particular, in the case of relapse, the extremely low survival rate has been a serious concern. Therefore, new treatments for AML are needed. Contents of the invention

[0004] Provided herein is a method of treating or preventing acute...

Claims

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