105 results about "AML - Acute myeloid leukemia" patented technology

Provided herein are chimeric antigen receptors (CARs) for cancer therapy, and more particularly, CARs containing a scFv from a CD33 monoclonal antibody. Provided are immune effector cells containing such CARs, and methods of treating proliferative disorders such as acute myeloid leukemia (AML), and relapsed or refractory AML.

Conformationally constrained compounds that are novel and mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins and having bicyclic framework are disclosed, as well as their prodrugs. Such reverse-turn mimetic structures and pro-drugs have utility over a wide range of fields, including use as diagnostic and therapeutic agents. The invention also relates to a use of such compounds for the preparation of a medicament for treating or preventing cancer including an acute myeloid leukemia.

The invention belongs to the technical field of medicines, and in particular discloses a detection marker and kit for B lymphoma and leukemia and application of the detection marker and the kit. The invention provides a P4HA2 gene or protein and application of Carabin protein in preparation of a diagnosis kit or treating B lymphoma and leukemia. Study shows that the P4HA2 gene and protein are barely expressed or slightly expressed in normal people or reactive lymph nodes, and are remarkably highly expressed in diffuse large B cell lymphoma; Carabin protein is slightly expressed in the diffuse large B cell lymphoma. In addition, the expression of the P4HA2 gene in an acute myeloid leukemia blood sample is remarkably higher than that in normal people; the diffuse large B cell lymphoma of which expression of the P4HA2 gene is knocked down is slowly proliferated, and the tumorigenic ability of a nude mouse is remarkably degraded. Therefore, the P4HA2 gene can be used as a diagnosis marker and a treatment target of the hematopoiesis and lymphoma, and the Carabin protein can be also used as a diagnosis marker of such diseases. The invention further provides a corresponding detection method and kit.

The invention discloses a newly discovered Flt3 phosphorylation site, tyrosine 969 (Tyr969) in the intracellular domain, and provides reagents, including polyclonal and monoclonal antibodies, that selectively bind to Flt3 when phosphorylated at this site. Also provided are assays utilizing this reagent, including methods for determining the phosphorylation of Flt3 in a biological sample, selecting a patient suitable for Flt3 inhibitor therapy, profiling Flt3 activation in a test tissue, and identifying a compound that modulates phosphorylation of Flt3 in a test tissue, by using a detectable reagent, such as the disclosed antibody, that binds to Flt3 only when phosphorylated at Tyr969. The sample or test tissue may be taken from a subject suspected of having cancer, such as acute myelogenous leukemia (AML).

The invention relates to an acute myeloid leukemia miRNA and transcription factor model and a construction method and application thereof. The construction method includes: acquiring differential expression miRNA and different expression transcription factors of marrow samples of acute myeloid leukemia patients and a healthy contrast group, constructing a miRNA-transcription factor regulatory network model to obtain core miRNA and core transcription factors, and the like. The constructed miRNA and transcription factor model can be used for construction of diagnosis probes, chips or reagents, equipment and the like to provide intermediate result information or reference information for diagnosis of the acute myeloid leukemia patients. By the acute myeloid leukemia miRNA and transcription factor model, microRNA mediated network regulation contents are enriched, and an action mechanism of a microRNA and transcription factor mediated regulation network in AML (acute myeloid leukemia) is revealed. Research results lay the foundation for development of anti-leukemia medicines or biological products, and high application value is achieved.

In alternative embodiment, provided are methods and compositions for treating, ameliorating or preventing diseases and conditions, such as cancer, including cancers associated with stem cells such as, without limitation, myelodysplastic syndrome (MDS) and a myeloproliferative neoplasm like chronic myeloid leukemia (CML) or acute myeloid leukemia (AML), and ablating or killing cancer stem cells. In alternative embodiment, provided are a new set of biomarkers to detect leukemia stem cell reprogramming and CML progression. In alternative embodiment, provided are therapeutic targets for treating myelodysplastic syndrome (MDS) and chronic myeloid leukemia (CML) by targeting edited let-7 transcripts.

The invention belongs to the technical field of medicines and in particular relates to a type of novel steroid saponin compounds and an application thereof. The steroid saponin compounds are prepared by the steps: performing degreasing treatment on solanum nigrum green fruits, performing solvent extraction, eluting by using a D101 macroporous resin column, separating through repeated silica gel column chromatography, reversed-phase MPLC (Middle Pressure Liquid Chromatography), Sephadex LH-20 column chromatography, semi-preparative reversed phase HPLC (High Performance Liquid Chromatography) and other means, thereby obtaining the product. Nine compounds with clear chemical structures are identified by virtue of physico-chemical constants and modern spectroscopy means. Pharmacodynamic experiments prove that the nine novel steroid saponin compounds have excellent in-vitro anti-inflammatory activities and have different degrees of tumor inhibiting effects on three tumor strains of human acute myeloid leukemia cells HL-60, human tissue lymphoma cells U937 and human hepatoma cells HepG2. The novel steroid saponin compounds can be further taken as anti-inflammatory and antitumor drugs to be researched and developed.

Methods for treating cancer, and preferably hematological malignancy, patients include analyzing gene expression profiles and/or molecular markers of a patient to determine status and/or prognosis of the patient. The invention also provides methods of analyzing whether a non-relapsed or non-refractory patient is likely to respond to treatment with farnesyl transferase inhibitors (FTIs) and, optionally, other therapeutics. The methods are also useful for monitoring patient therapy and for selecting a course of therapy. Genes modulated in response to FTI treatment are provided and are used in formulating the profiles.

The invention discloses an application of a securinine linked dimeric compound SN3-L6 or pharmaceutical salt thereof in preparation of anti-leukemia drugs. It is found that the SN3-L6 has a relativelygood in-vitro anti-leukemia effect, and can obviously inhibit the proliferation of acute myeloid leukemia cells; the SN3-L6 can induce the cells to transdifferentiate into megakaryocytes and then induce the megakaryocytes to generate platelets, so that the SN3-L6 has a good medicinal prospect in the aspects of acute myeloid leukemia transdifferentiation treatment and in-vitro platelet generation;and the SN3-L6 can also induce transdifferentiation of chronic erythroleukemia cells into megakaryocytes and then induce apoptosis of the megakaryocytes, so that the SN3-L6 also has a good medicinalprospect in the aspect of chronic erythroleukemia treatment.

The present invention relates to the treatment of leukemia, (e.g. acute myeloid leukemia, AML) using a triple combination of: arsenic trioxide; iron; and an artemisinin, such as artesunate.

The invention provides the use of whole blood samples or samples comprising peripheral blood mononuclear cells (PBMCs) for diagnosing or evaluating the progression or treatment of leukemia. Genes that are differentially expressed in un-fractionated PBMCs of leukemia patients, as compared to in disease-free humans or in patients who have a differential type of leukemia, can be identified according to the invention. These genes are leukemia disease genes and can be used to detect the presence or progression of leukemia in a subj ect of interest. Leukemias that are amenable to the present invention include, but are not limited to, acute myelogenous leukemia (AML) and myelodysplastic syndromes (MDS). Non-limiting examples of AML or MDS disease genes are provided in Tables 2, 4 and 6.