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Preparation of polyvinyl alcohol-based hydroge

A polyvinyl alcohol-based and polyvinyl alcohol technology is applied in the field of preparation of polyvinyl alcohol-based hydrogels, which can solve the problems of complicated preparation methods of PVA hydrogels, achieve easy wound recovery, reduce production costs, and be easy to observe. Effect

Inactive Publication Date: 2020-01-17
SHAANXI GIANT BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the preparation method of PVA hydrogel obtained by physical cross-linking method is relatively cumbersome; the obtained product also needs to be improved in terms of biocompatibility

Method used

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  • Preparation of polyvinyl alcohol-based hydroge
  • Preparation of polyvinyl alcohol-based hydroge
  • Preparation of polyvinyl alcohol-based hydroge

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0038] The preparation methods of PVA hydrogel include physical cross-linking methods (freeze-thaw cycle method, freezing-partial dehydration method) and chemical cross-linking methods (reagent cross-linking method, radiation cross-linking method).

[0039] The invention here relates to freeze-thaw cycling, which is a physical cross-linking method. The physical cross-linking method is to form a three-dimensional network between molecular chains through hydrogen bonds and microcrystalline regions, that is, physical cross-linking points, and these cross-linking points change with changes in external conditions such as temperature. Therefore, the physical cross-linking process is reversible.

[0040] The advantage of the physical cross-linking method is that it does not use toxic organic cross-linking agents and maintains good biocompatibility. Can be dissolved, the method is simple. After repeated thawing, the hydrogel has high strength, high elasticity and high water content....

Embodiment 1

[0067] Step 1: In a water bath at 90°C, polyvinyl alcohol (purchased from Sigma, model number 341584-1KG) was dissolved in 20 mL of deionized water to obtain a clear solution of 11% polyvinyl alcohol.

[0068] Step 2: Dissolve polyethylene glycol (purchased from Sigma, model number 86101-1KG-F) powder into the solution in Step 1 at a content of 9%, and dissolve until clear.

[0069] Step 3: Dissolve nano-hydroxyapatite powder (purchased from Nanjing Epurui Nano Material Co., Ltd. model as HAP-04-20) into the mixed solution in step 2 with a content of 7%, stir evenly, pour into the mold, and put Freeze in -20°C freezer for 4 hours.

[0070] Step 4: The frozen hydrogel was placed at 20° C. for three hours, and then put into deionized water to wash out polyethylene glycol and nano-hydroxyapatite.

[0071] The polyvinyl alcohol used in step 1 has a molecular weight of 89000-98000Da, the polyethylene glycol used in step 2 has a molecular weight of 1500Da, and the particle size of ...

Embodiment 2

[0075] Step 1: In a water bath at 90° C., the same polyvinyl alcohol as in Example 1 was dissolved in 20 mL of deionized water to obtain a 10% clear solution of polyvinyl alcohol.

[0076] Step 2: Dissolve the same polyethylene glycol powder as in Example 1 in the solution of Step 1 with a content of 9%, and make it dissolve until clear.

[0077] Step 3: Dissolve the same nano-hydroxyapatite powder as in Example 1 at a content of 8% into the mixed solution in Step 2, stir evenly, pour into a mold, and freeze in a -20°C refrigerator for 4 hours.

[0078] Step 4: The frozen hydrogel was placed at 20° C. for three hours, and then put into deionized water to wash out polyethylene glycol and nano-hydroxyapatite.

[0079] The polyvinyl alcohol used in step one has a molecular weight of 89000-98000Da, the polyethylene glycol used in step two has a molecular weight of 1500Da, and the nano-hydroxyapatite used in step three has a particle size of 20nm.

[0080] By the preparation metho...

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Abstract

The invention relates to a polyvinyl alcohol-based hydrogel, wherein the raw materials are polyvinyl alcohol, polyethylene glycol and nanometer hydroxyapatite. The synthesis method comprises: dissolving polyvinyl alcohol in deionized water in a 90-DEG C water bath kettle, dissolving polyethylene glycol in the polyvinyl alcohol solution, adding nanometer hydroxyapatite, uniformly stirring, pouringinto a mold, and freezing for 4 h. According to the invention, the prepared polyvinyl alcohol hydrogel has excellent biocompatibility, high porosity, excellent mechanical properties and the like.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a preparation method of polyvinyl alcohol-based hydrogel. Background technique [0002] Hydrogel is a hydrophilic and soft substance with a three-dimensional network structure, which can absorb and maintain a large amount of water without dissolving. The various advantages of hydrogel make it applicable to many biomedical researches, including toughness, recoverability sex and self-healing. The commonly used materials of hydrogel mainly include collagen, chitosan, hyaluronic acid and other natural materials, as well as polyvinyl alcohol (PVA), polyethylene glycol (PEG), polylactic acid (PLA), polyglycolic acid (PGA), etc. Synthetic materials. The commonly used cross-linking methods of hydrogels include physical cross-linking, chemical cross-linking, and biological cross-linking. Commonly used pore-making methods include vacuum freeze-drying, phase separation, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/28C08J3/075C08J3/24C08L29/04A61L26/00
CPCA61L26/008A61L26/0085A61L26/0095C08J3/075C08J3/24C08J9/28C08J2201/0482C08J2201/0484C08J2329/04C08J2471/02C08L29/04
Inventor 范代娣张维钰马晓轩
Owner SHAANXI GIANT BIOTECHNOLOGY CO LTD
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