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Radix astragali-penicillium cicada fermentation bacterium and application thereof

A technology of Paecilomyces cicadae and fermenting bacteria, applied in the field of traditional Chinese medicine fermentation mycoplasma, can solve problems such as no reports on the pharmacological activity of Astragalus-Paecilomyces cicadae fermentative mycoplasma, etc., and achieves the treatment of hyperuricemia and/or hyperuricemia. Triglyceridemia, the effect of increasing polysaccharide content

Active Publication Date: 2020-01-21
BINZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no research report on the pharmacological activity of Astragalus-Paecilomyces cicadae fermented bacteria

Method used

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  • Radix astragali-penicillium cicada fermentation bacterium and application thereof
  • Radix astragali-penicillium cicada fermentation bacterium and application thereof
  • Radix astragali-penicillium cicada fermentation bacterium and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035]The medicinal materials of Astragalus are pulverized and passed through an 8-mesh sieve to obtain the medicinal powder of Astragalus. The medicinal powder of astragalus and distilled water are uniformly mixed in a weight ratio of 2.5:1, placed in a 90° C. steam sterilizer for sterilization for 60 minutes, and cooled to room temperature to obtain an astragalus solid medium. Paecilomyces cicadae was evenly inoculated into the solid medium of Astragalus, and the inoculation amount was 10wt% of the medicinal materials of Astragalus, and cultured at constant temperature and humidity for 24 days under the conditions of a culture temperature of 26°C and a relative humidity of 80% to obtain Astragalus-Paecilomyces cicadae fermentation. Mycoplasma A (hereinafter referred to as "mycoplasma A").

Embodiment 2

[0037] The medicinal materials of Astragalus are pulverized and passed through an 8-mesh sieve to obtain the medicinal powder of Astragalus. The medicinal powder of astragalus and distilled water are uniformly mixed in a weight ratio of 2.5:1, placed in a 90° C. steam sterilizer for sterilization for 60 minutes, and cooled to room temperature to obtain an astragalus solid medium. Paecilomyces cicadae was evenly inoculated into the solid medium of Astragalus, and the inoculation amount was 10 wt% of the medicinal material of Astragalus; the seed liquid of Paecilomyces cicadae was evenly inoculated into the solid medium of Astragalus, and the inoculation amount was 4 wt% of the medicinal material of Astragalus, Under the conditions of a culture temperature of 26° C. and a relative humidity of 80%, cultured at constant temperature and humidity for 24 days to obtain Astragalus-Paecilomyces cicadae fermentation mycoplasma B (hereinafter referred to as “mycoplasma B”).

experiment example 1

[0046] Experimental example 1 Determination of bacterial growth consumption rate

[0047] Astragalus - Paecilomyces cicadae fermentation mycelium A to E were all sampled on the 24th day of fermentation, the bottom and surface of the fermentation substrate were covered with dense mycelium, the wet weight of the mycelium was measured, and the mycelium was washed three times with distilled water, and then placed Dry in a 60°C oven to constant weight, weigh, calculate the weight change before and after fermentation, and calculate the consumption rate. The higher the consumption rate, the better the culture conditions are for mycelial growth.

[0048] Consumption rate = (the weight of the original medicinal material - the weight of the fungus after drying and fermentation) / the weight of the original medicinal material × 100%.

[0049] The results are shown in Table 1.

[0050] Table 1

[0051]

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Abstract

The invention discloses a radix astragali-penicillium cicada fermentation bacterium and application thereof. The fermentation bacterium is prepared from medicinal radix astragali powder as a fermentation substrate and penicillium cicada as a fermentation bacterium through solid fermentation. The radix astragali-penicillium cicada fermentation bacterium disclosed by the invention has a remarkable function of treating hyperuricemia and hypertriglyceridemia.

Description

technical field [0001] The invention relates to a traditional Chinese medicine fermentation fungus and its application, in particular to astragalus-Paecilomyces cicadae fermentation fungus and its use in the preparation of medicines for treating hyperuricemia and / or hypertriglyceridemia. Background technique [0002] Fermentation of traditional Chinese medicine is to use the action of enzymes and microorganisms, under certain environmental conditions (such as temperature, humidity, air, moisture, etc.), to make the medicine change its original performance, enhance or produce new efficacy, and expand the variety of medicines through the fermentation process. , to meet the needs of clinical medication. Traditional Chinese medicine fermentation is a microbial fermentation technology, which refers to the method that after the medicine is purified or treated, under certain temperature and humidity conditions, the medicine is catalyzed and decomposed by microorganisms and enzymes ...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61P19/06A61P3/06
CPCA61K36/481A61P19/06A61P3/06A61K2236/19C12N1/14C12R2001/79A61K36/06A61K2300/00C12N2523/00
Inventor 张加余代龙王少平耿子凯王喻淇
Owner BINZHOU MEDICAL COLLEGE
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