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Enhanced anti-hair loss and hair growth composition

A hair loss prevention and composition technology, which is applied in the direction of drug combination, hair care, medical preparations containing active ingredients, etc., can solve the problems of severe hair loss, drug dependence, high cost of surgical treatment, etc.

Active Publication Date: 2020-01-31
NATURAL MEDICINE INST OF ZHEJIANG YANGSHENGTANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drug treatment mainly includes finasteride and minoxidil, which often have serious side effects and are prone to drug dependence. Once the drug is stopped, hair loss will be more serious; surgical treatment is expensive, traumatic, and requires a certain recovery period

Method used

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  • Enhanced anti-hair loss and hair growth composition
  • Enhanced anti-hair loss and hair growth composition
  • Enhanced anti-hair loss and hair growth composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 : Inhibition of 5α-reductase activity

[0031] In this example, the effects of different times of concentrated birch sap, ginger extract, Polygonum multiflorum root extract, ginseng extract, green tea extract, orientalis extract, and their compositions on 5α-reductase activity were investigated and compared. Impact.

[0032] 1. Concentration of birch sap

[0033] The fresh white birch sap stock solution purchased from Daxinganling Chaoyue Wild Berry Development Co., Ltd. was input into a low-temperature drying equipment, cooled to -65°C, vacuumed to 0.1Pa, and concentrated 1.5 and 10 times.

[0034] 2. Test

[0035] Experimental equipment: balance, wall breaking machine, constant temperature oscillator, high-speed refrigerated centrifuge, microplate reader.

[0036] Experimental reagents and consumables:

[0037] Finasteride: Shanghai Modern Pharmaceutical Co., Ltd. (tablet 5mg / tablet);

[0038] Reduced coenzyme Ⅱ (NADPH): American Roche company (powder ...

Embodiment 2

[0060] Example 2 : Effects on the expression of genes and proteins related to anti-hair loss

[0061] In the present embodiment, investigate and compare different multiples of concentrated birch sap, angelica extract, astragalus, eclipta, birch bud extract, birch leaf extract, and their compositions on anti-hair loss and hair growth-related genes and effect on protein expression.

[0062] 1. Concentration of birch sap

[0063] The fresh white birch sap stock solution purchased from Daxinganling Chaoyue Wild Berry Development Co., Ltd. was input into a low-temperature drying equipment, cooled to -65°C, vacuumed to 0.1Pa, and concentrated 1.5 and 10 times.

[0064] 2. Test

[0065] The dermal papilla cells used in this experiment were produced by Guangdong Boxi Biotechnology Co., Ltd.

[0066] Experimental instrument: CO 2 Incubator (Thermo), Clean Bench (Sujing Antai), Inverted Microscope (Olympus), Micro Shaker (Qilin Bell), Microplate Reader (BioTek), Incubator (Test), ...

Embodiment 3

[0086] Example 3 : Effect on proliferation and differentiation of dermal papilla cells

[0087] In this example, the effects of different multiples of concentrated birch sap, adenosine, nicotinamide, tripeptide-1 copper, and their compositions on the proliferation and differentiation of dermal papilla cells were investigated and compared.

[0088] 1. Concentration of birch sap

[0089] The fresh white birch sap stock solution purchased from Daxinganling Chaoyue Wild Berry Development Co., Ltd. was input into a low-temperature drying equipment, cooled to -65°C, vacuumed to 0.1Pa, and concentrated 1.5 and 10 times.

[0090] 2. Test method

[0091] The dermal papilla cells used in this experiment were produced by Guangdong Boxi Biotechnology Co., Ltd.

[0092] Experimental instrument: CO 2 Incubator (Thermo), ultra-clean bench (Sujing Antai), inverted microscope (Olympus), micro shaker (Qilin Bell), microplate reader (BioTek), incubator (Test).

[0093] Experimental reagent...

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Abstract

The invention provides an enhanced hair loss prevention and hair growth composition. The composition comprises: (A) concentrated birch juice; and (B) one or a combination of more of raw ginger extract, polygonum multiflorum root extract, ginseng extract, green tea extract, platycladus orientalis extract, angelica sinensis extract, astragalus membranaceus, eclipta alba, silver birch bud extract, silver birch leaf extract, adenosine, nicotinamide and tripeptide-1 copper. The concentration multiple of the concentrated birch juice is about 1.2-8 times, preferably about 1.5-6 times, more preferablyabout 1.5-5 times.

Description

technical field [0001] The present invention relates to an enhanced anti-hair loss composition comprising (A) birch sap concentrate and (B) ginger extract, fleece-flower root extract, ginseng extract, green tea extract, arborvitae extract, angelica extract Herbal medicine, astragalus, eclipta, birch bud extract, birch leaf extract, adenosine, nicotinamide, tripeptide-1 copper, wherein the concentration ratio of the concentrated birch sap It is about 1.2-8 times, preferably about 1.5-6 times, more preferably about 1.5-5 times. Background technique [0002] With the acceleration of the pace of life in modern society and the deterioration of the environment, more and more people have different degrees of sub-health problems under the conditions of high-intensity mental stress, overtime, staying up late, and smog. This brings problems such as increased scalp oil secretion, scalp inflammation, hair follicle atrophy, and hair loss. Hair loss has become a topic of increasing conc...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/9794A61K8/9761A61K8/67A61K8/64A61K8/49A61Q5/02A61Q7/00A61P17/14
CPCA61K8/9789A61K8/9794A61K8/9761A61K8/4973A61K8/675A61K8/64A61Q5/02A61Q7/00A61P17/14A61K2800/782
Inventor 赵瑞丽王莎莎
Owner NATURAL MEDICINE INST OF ZHEJIANG YANGSHENGTANG
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