Tumor cell detection probe and preparation method and application thereof
A tumor cell and detection probe technology, which is applied in the field of tumor cell detection probes and their preparation, can solve the problems of high cost and complicated probe design, and achieves high detection sensitivity, good targeting, fluorescence imaging, and detection. Accurate and efficient results
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Embodiment 1
[0028] In this embodiment, a tumor cell detection probe is provided, and the tumor cell detection probe includes a carrier, a low molecular weight heparin-modified cadmium telluride quantum dot and a tumor targeting ligand loaded on the carrier; the carrier It is a PEG-PLA block polymer, wherein the number average molecular weight of the PEG-PLA block polymer is 5000, and the low molecular weight heparin-modified cadmium telluride quantum dots are loaded on the carrier through carboxyl-hydroxyl crosslinking, and the tumor The targeting ligand is loaded on the carrier through amino-carboxyl crosslinking; the molecular weight of the low molecular weight heparin is 3500, the tumor targeting ligand is RGD peptide, and the carrier, low molecular weight heparin modified cadmium telluride quantum dots The molar ratio with tumor targeting ligand is 20:8:1.
[0029] The tumor cell detection probe is self-assembled to form a self-assembled nanometer system.
Embodiment 2
[0031] In this embodiment, a tumor cell detection probe is provided, and the tumor cell detection probe includes a carrier, a low molecular weight heparin-modified cadmium telluride quantum dot and a tumor targeting ligand loaded on the carrier; the carrier It is a PEG-PLA block polymer, wherein the number average molecular weight of the PEG-PLA block polymer is 2000, and the low molecular weight heparin-modified cadmium telluride quantum dots are loaded on the carrier through carboxyl-hydroxyl crosslinking, and the tumor The targeting ligand is loaded on the carrier through amino-carboxyl cross-linking; the molecular weight of the low molecular weight heparin is 5500, the tumor targeting ligand is RGD peptide, and the carrier, low molecular weight heparin modified cadmium telluride quantum dots The molar ratio to the tumor targeting ligand is 42:25:1.
[0032] The tumor cell detection probe is self-assembled to form a self-assembled nanometer system.
Embodiment 3
[0034] In this embodiment, a tumor cell detection probe is provided, and the tumor cell detection probe includes a carrier, a low molecular weight heparin-modified cadmium telluride quantum dot and a tumor targeting ligand loaded on the carrier; the carrier It is a PEG-PLA block polymer, wherein the number average molecular weight of the PEG-PLA block polymer is 8000, and the low molecular weight heparin-modified cadmium telluride quantum dots are loaded on the carrier through carboxyl-hydroxyl crosslinking, and the tumor The targeting ligand is loaded on the carrier through amino-carboxyl cross-linking; the molecular weight of the low molecular weight heparin is 4000, the tumor targeting ligand is RGD peptide, and the carrier, low molecular weight heparin modified cadmium telluride quantum dots The molar ratio with tumor targeting ligand is 80:35:1.
[0035] The tumor cell detection probe is self-assembled to form a self-assembled nanometer system.
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