55 results about "Heparin.low molecular weight" patented technology

Preparations of low molecular weight heparins (LMWHs) having improved properties, e.g., properties that provide a clinical advantage, are provided herein. Methods of making and using such preparations as well as methods of analyzing starting materials, processing, intermediates and final products in the production of such LMWH preparations are provided.

The invention relates to a scale disk for nursing operation of low-molecular weight heparin injection. The scale disk comprises a main disk body and meter moving double wings. The main disk body comprises a positioning disk, an inner circumferential rail, an outer circumferential rail, a scale sector plate, a pointer positioning rod, and a concentric positioning rod. The inner circumferential rail is arranged on the outer edge of the positioning disk. The scale sector plate is slidably configured between the inner circumferential rail and the outer circumferential rail. The meter moving double wings are slidably configured on the outer circumferential rail of the main disk body. Aimed at injection medicine characteristics of low-molecular weight heparin, horizontal, longitudinal, and circumferential distances of an injection position are accurately controlled around 20 mm. through the positioning disk, an injection range is positioned, a central positioning plate aligns at a basic injection point, an injection forbidden annular plate shields an injection forbidden region, the pointer positioning rod positions angles and longitudinal interval, and the concentric positioning rod positions distance and horizontal interval. After positioning holes of the two positioning rods are overlapped, a position most suitable for injection is accurately founded, so operation of a nurse is more accurate and rapid, and difficulty of self-operation of an intern doctor and a patient is effectively reduced.

The invention discloses a heparin lyase mutant and a recombinant expression method thereof, belonging to the technical field of bioengineering. The heparin lyase III provided by the invention has higher catalytic efficiency and thermal stability, and the catalytic efficiency of the mutant S264F / Y490K / D321N is 1.68 times higher than that of the original strain, which is more conducive to the preparation of low molecular weight heparin. The invention also performs heterologous recombination expression on the heparin lyase III from the Bacteroides proteus, and the intracellular enzyme activity can reach more than 4000U / L.

The field of pharmaceutical preparations of the present invention relates to a calcium phosphate-lipid nano-drug co-delivery system composed of low-molecular-weight heparin and natural drug prodrugs and a preparation method thereof. The present invention uses nanoparticles prepared from biodegradable lipid materials as a carrier , and physically encapsulates the phosphorylated prodrug PIC-POOH of the natural drug PIC, and electrostatically adsorbs LMWH on the outer layer, and utilizes the long-circulation properties of nano-preparations and the EPR effect of solid tumor tissues to enrich in tumor sites, thereby regulating tumor cell metastasis-related pathways , inhibit angiogenesis, anti-tumor metastasis. Experiments show that the drug co-delivery system can inhibit the EMT process of tumor cells, and can significantly inhibit tumor angiogenesis through tubule formation experiments. and prolong the survival period of tumor-bearing mice; it has obvious anti-tumor metastasis effect, especially reduces triple-negative breast cancer metastasis, and has good safety.

The invention discloses a bone targeting liposome modified by low molecular weight heparin and a preparation method thereof. The bone-targeted liposomes include cationic liposomes and alendronate-low molecular weight heparin polymers adsorbed on the surface of cationic liposomes; Sodium phosphonate and low molecular weight heparin are linked by an amide bond. The present invention introduces alendronate sodium with active targeting effect on low molecular weight heparin, and modifies it on the surface of cationic liposome by electrostatic adsorption for delivery of chemotherapeutic drugs, which not only improves the active targeting of the preparation It enhances the efficacy of the drug, reduces the potential risk of tumor metastasis, and further improves the possibility of clinical treatment.