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Preparation method of lipid-lowering medicinal tablet with good sustained-release effect

A tablet and lipid-lowering technology, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, and pharmaceutical formulations, etc., can solve the problem of unstable drug release rate, unstable blood drug concentration of patients, and difficulty in screening excipients. and other problems, to achieve the effect of great market competitiveness, promotion and use value, significant control effect, and good slow-release effect.

Inactive Publication Date: 2020-02-07
阜阳市恒唛食品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, due to the complexity of the components of traditional Chinese medicine extracts, there are technical problems in the preparation of sustained-release preparations of traditional Chinese medicine, such as difficult selection of excipients, poor molding process and unstable drug release rate.
As a result, although there are traditional Chinese medicine lipid-lowering agents on the market, taking the medicine frequently will lead to unstable blood drug concentration in the patient's body, which cannot effectively exert its pharmacological effects, and is far from meeting the clinical needs.

Method used

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  • Preparation method of lipid-lowering medicinal tablet with good sustained-release effect
  • Preparation method of lipid-lowering medicinal tablet with good sustained-release effect
  • Preparation method of lipid-lowering medicinal tablet with good sustained-release effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A preparation method for a lipid-lowering tablet with good sustained-release effect, comprising the steps of:

[0038] (1) The raw materials of traditional Chinese medicine are weighed for later use:

[0039] Weigh the following traditional Chinese medicine raw materials according to the corresponding parts for later use: 20 parts of Panax notoginseng, 5 parts of Hawthorn, 3 parts of Polygonum multiflorum, 2 parts of Salvia miltiorrhiza, 4 parts of Pueraria lobata;

[0040] (2) Cleaning, drying and crushing treatment:

[0041] Clean the Panax notoginseng, hawthorn, Polygonum multiflorum, Salvia and Pueraria root weighed in step (1) with clean water, and then dry them, and finally put the Panax notoginseng, hawthorn, Polygonum multiflorum, Salvia and Puerariae together into the grinder for crushing After processing, take it out and mix it with Chinese medicine powder for later use;

[0042] (3) Steam explosion treatment:

[0043] Put the mixed traditional Chinese medi...

Embodiment 2

[0064] A preparation method for a lipid-lowering tablet with good sustained-release effect, comprising the steps of:

[0065] (1) The raw materials of traditional Chinese medicine are weighed for later use:

[0066] Weigh the following traditional Chinese medicine raw materials according to the corresponding parts for later use: 23 parts of Panax notoginseng, 7 parts of Hawthorn, 5 parts of Polygonum multiflorum, 4 parts of Salvia miltiorrhiza, 6 parts of Pueraria lobata;

[0067] (2) Cleaning, drying and crushing treatment:

[0068] Clean the Panax notoginseng, hawthorn, Polygonum multiflorum, Salvia and Pueraria root weighed in step (1) with clean water, and then dry them, and finally put the Panax notoginseng, hawthorn, Polygonum multiflorum, Salvia and Puerariae together into the grinder for crushing After processing, take it out and mix it with Chinese medicine powder for later use;

[0069] (3) Steam explosion treatment:

[0070] Put the mixed traditional Chinese medi...

Embodiment 3

[0091] A preparation method for a lipid-lowering tablet with good sustained-release effect, comprising the steps of:

[0092] (1) The raw materials of traditional Chinese medicine are weighed for later use:

[0093] Weigh the following traditional Chinese medicine raw materials according to the corresponding parts for later use: 25 parts of Panax notoginseng, 8 parts of Hawthorn, 6 parts of Polygonum multiflorum, 5 parts of Salvia miltiorrhiza, 7 parts of Pueraria lobata;

[0094] (2) Cleaning, drying and crushing treatment:

[0095]Clean the Panax notoginseng, hawthorn, Polygonum multiflorum, Salvia and Pueraria root weighed in step (1) with clean water, and then dry them, and finally put the Panax notoginseng, hawthorn, Polygonum multiflorum, Salvia and Puerariae together into the grinder for crushing After processing, take it out and mix it with Chinese medicine powder for later use;

[0096] (3) Steam explosion treatment:

[0097] Put the mixed traditional Chinese medic...

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Abstract

The present invention discloses a preparation method of a lipid-lowering medicinal tablet with a good sustained-release effect. The preparation method comprises the following steps: (1) traditional Chinese medicine raw material weighing for a standby application; (2) washing, drying and crushing; (3) steam blasting; (4) enzyme digesting; (5) traditional Chinese medicine extract powder preparing; (6) auxiliary material preparing; and (7) finished product medicinal tablet preparing. The special preparation method of the lipid-lowering medicinal tablet significantly improves extraction rate of active ingredients in traditional Chinese medicine ingredients, improves utilization rate of raw materials, and is suitable for large-scale industrial production. Besides, the prepared lipid-lowering medicinal tablet has significant prevention and treatment effects on hyperlipidemia symptoms, is good in medicine effects and easy for absorption, and also has a very good sustained release effect.

Description

technical field [0001] The invention belongs to the technical field of extraction and preparation of traditional Chinese medicines, and in particular relates to a preparation method of a lipid-lowering tablet with good slow-release effect. Background technique [0002] With the continuous acceleration of people's life rhythm and the accumulation of excess dietary nutrition, the number of patients with three high symptoms is increasing, and the trend of rejuvenation is obvious, which seriously endangers human health. Hyperlipidemia is one of the three high symptoms, which refers to the high blood lipid level, which can directly cause some diseases that seriously endanger human health, such as atherosclerosis, coronary heart disease, pancreatitis, etc. Due to abnormal fat metabolism or operation, one or more lipids in plasma are higher than normal, which is called hyperlipidemia. Lipids that are insoluble or slightly soluble in water must be combined with proteins to exist in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K47/04A61K47/36A61K47/38A61K47/42A61K47/10A61K36/734A61P3/06
CPCA61K9/2009A61K9/2031A61K9/2054A61K9/2059A61K9/2063A61K9/2095A61K36/258A61K36/488A61K36/537A61K36/704A61K36/734A61K2236/15A61K2236/19A61K2236/53A61P3/06A61K2300/00
Inventor 郭坤张海涛
Owner 阜阳市恒唛食品有限公司
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