Refining and crystallization method of sugammadex sodium
A technology of sugammadex sodium and quality, applied in the field of medicinal chemistry, can solve problems such as difficulty in the preparation process, and achieve the effects of good fluidity, high product yield and purity, and improved dissolution rate
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Embodiment 1
[0033] Weigh 10g of sugammadex sodium, add 20g of water to dissolve completely at room temperature, mechanically stir at 150rpm, filter to obtain a clear solution, adjust the pH of the solution to 6.178, and the temperature to 20°C; drop methanol at 20°C in 3 times Into the solution: drop 40g methanol into the solution, the dropping time is 30min, and grow the crystal for 1h; drop 8g methanol into the solution, the dropping time is 2h; drop 80g methanol into the solution, the dropping time is 1h; drop the temperature quickly after the dropping to 10° C., filtered, and vacuum dried at 90° C. for 24 hours to obtain about 9.35 g of the product with a yield of 93.5%, a product purity of 99.05%, a spherical shape and good fluidity.
Embodiment 2
[0035] Weigh 10g of sugammadex sodium, add 40g of water to dissolve completely at room temperature, mechanically stir at 150rpm, filter to obtain a clear solution, adjust the pH of the solution to 9.327, and raise the temperature to 70°C; drop methanol at 70°C in 3 drops Adding to the solution: drop 120g methanol into the solution, the dropping time is 5h, and grow the crystal for 1h; 80g methanol is dropped into the solution, the dropping time is 8h; 160g methanol is dropped into the solution, the dropping time is 10h; Cool down to 30°C, filter, and vacuum-dry at 90°C for 24 hours to obtain about 9.31g of product with a yield of 93.1% and a product purity of 99.02%. The product is spherical in shape and has good fluidity.
Embodiment 3
[0037] Weigh 10g of sugammadex sodium, add 25g of water to dissolve completely at room temperature, mechanically stir at 150rpm, filter to obtain a clear solution, adjust the pH of the solution to 7.574 and raise the temperature to 50°C; drop methanol at 25°C three times Add dropwise into the solution: drop 72g methanol into the solution for 100min, and grow the crystal for 1h; drop 16g methanol into the solution, dropwise for 5h; drop 112g methanol into the solution, dropwise for 3h; Rapidly cool down to 25°C, filter, and vacuum-dry at 90°C for 24 hours to obtain about 9.33g of product with a yield of 93.3% and a product purity of 99.07%. The product is spherical in shape and has good fluidity.
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