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Lumbar kidney cream fingerprint spectrum establishing method and Lumbar kidney reference fingerprint spectrum

A technology for comparing fingerprints and fingerprints, applied in the field of drug analysis, can solve problems such as many components and complexities, and achieve the effects of many peaks, high precision, and stable and reliable quality standards.

Active Publication Date: 2020-02-21
SINOPHARM GRP DEZHONG (FOSHAN) PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to its many and complex components, there is currently a lack of methods to fully reflect its quality and authenticity, and there is currently no research report on the fingerprint of Yaoshen paste. It has great significance and can provide a comprehensive quality control method for Yaoshen ointment

Method used

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  • Lumbar kidney cream fingerprint spectrum establishing method and Lumbar kidney reference fingerprint spectrum
  • Lumbar kidney cream fingerprint spectrum establishing method and Lumbar kidney reference fingerprint spectrum
  • Lumbar kidney cream fingerprint spectrum establishing method and Lumbar kidney reference fingerprint spectrum

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Example 1: Methodological verification

[0057] Six parts of waist-kidney ointment of 18046 were selected, and the test solution was prepared according to the proposed method. Take the first copy for precision and stability investigation; total six copies for repeatability investigation.

[0058] Preparation of test solution: Take three pieces of waist kidney ointment and cut them into strips, tear off the backing, combine them into a mass in units of one piece, and stuff them into a 250ml flask, add 100ml of water, and then extract with 2ml of ethyl acetate. Reflux the volatile oil extractor for 3 hours on an electric heating mantle; after the reflux, let it cool, put the ethyl acetate layer of the volatile oil extractor into a separatory funnel, and rinse the volatile oil extractor with 2ml, 2ml, and 1ml ethyl acetate. Put it into a separatory funnel, discard the water layer, filter the ethyl acetate layer through a filter paper containing 1g of anhydrous sodium sulfate, ...

Embodiment 2

[0087] Example 2: Establishment of the fingerprint of Yaoshen Ointment

[0088] 1. Eliminate peaks of excipients

[0089] 1. Auxiliary peak of liquid phase spectrum

[0090] Waist kidney ointment is made by spreading a mixed ointment mass on an elastic cloth. The elastic cloth is soaked in methanol and ethanol so that the dye on the elastic cloth is eluted and enters the test solution. For this reason, try to use 50% ethanol and 50% methanol to reflux the elastic cloth of the waist and kidney ointment to reduce the amount of eluted dye to reduce the interference of similarity evaluation.

[0091] Chromatographic conditions: Instrument: Agilent 1100 High Performance Liquid Chromatograph. The elution conditions are shown in Table 3 below. Other chromatographic conditions are the same as the experimental conditions proposed in Example 1.

[0092] table 3

[0093] Time min Acetonitrile (%) 0.02% trifluoroacetic acid solution (%) 03070 206040 408020 581000 611000 673070 733070

[0094...

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Abstract

The invention discloses a lumbar kidney cream fingerprint spectrum establishing method and a lumbar kidney reference fingerprint spectrum. The fingerprint spectrum establishing method comprises the steps that (1) a sample is pretreated, wherein volatile components in lumbar kidney cream are absorbed by ethyl acetate to serve as a test sample for gas phase identification, water is added into the remaining cream, and the mixture is used as a test sample for liquid phase identification after being subjected to methanol ultrasonic extraction and liquid immersion; (2) gas phase analysis is performed on the test sample for gas phase identification to obtain a lumbar kidney cream gas phase fingerprint spectrum; and (3) liquid phase analysis is performed on the test sample for liquid phase identification to obtain a lumbar kidney cream liquid phase fingerprint spectrum. Through research about the lumbar kidney cream fingerprint spectra, a good lumbar kidney cream fingerprint spectrum is obtained, and a new technical method is provided for controlling the quality of the preparation.

Description

Technical field [0001] The invention relates to the field of drug analysis, and mainly relates to a method for establishing a fingerprint atlas of Yaoshen Ointment and a comparison fingerprint atlas of Yaoshen Ointment. Background technique [0002] The prescription of waist kidney ointment contains 20 kinds of medicinal materials such as Cistanche, star anise, rehmannia glutinosa, psoralen, epimedium, cnidii, hyssop, dipsacus, licorice, eucommia, plus camphor, borneol, peppermint oil, etc. It is white petrolatum, rubber, terpene resin, etc. This product has the effects of warming the kidneys and yang, strengthening muscles and bones, dispelling wind and relieving pain. It is used for waist and knee pain due to kidney deficiency, muscle aches and nocturia. Due to its many and complex ingredients, there is no comprehensive method to reflect its quality and authenticity at present, and there is no research report on the fingerprint of Yaoshen Ointment. Therefore, the research on ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/34G01N30/86
CPCG01N30/02G01N30/06G01N30/34G01N30/8686
Inventor 郭韵妍杜蔼媚招嘉文赵志峰邹婷
Owner SINOPHARM GRP DEZHONG (FOSHAN) PHARM CO LTD
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