Ultra-low field magnetic imaging device for living small animals

An ultra-low field, magnetic imaging technology, applied in the field of magnetic imaging, can solve problems such as inapplicability to large-sized and small animals, complex structure, etc., to reduce the impact of detection sensitivity, improve sensitivity, and expand the scope of application.

Active Publication Date: 2020-02-25
INST OF CHEM CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of the above analysis, the embodiment of the present invention aims to provide an ultra-low field magnetic imaging device for living small animals, to solve the problem that the ultra-low field magnetic imaging device in the prior art has a complex structure and is not suitable for large volume Problems with Live Scanning of Small Animals

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  • Ultra-low field magnetic imaging device for living small animals
  • Ultra-low field magnetic imaging device for living small animals
  • Ultra-low field magnetic imaging device for living small animals

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Embodiment 1

[0032] A specific embodiment of the present invention discloses an ultra-low-field magnetic imaging device for living small animals, including a push unit 1 and a magnetometer unit 2, and the push unit 1 includes a scanning translation stage 11, a push rod 12 and a load Table 13; scanning displacement stage 11, push rod 12, and object stage 13 are connected in sequence; magnetometer unit 2 includes magnetic shielding 21, scanning channel 22, optical channel 23, atomic gas pool 24, laser light source and detector 25, scanning channel 22 runs through the side of the magnetic shield 21, the atomic gas pool 24 is arranged on one side of the scanning channel 22, an optical focusing lens 211 is arranged on the side close to the atomic gas pool 24 in the magnetic shield 21, and a single The side heating coil 212, the magnetic shield 21 is provided with a magnetic field balance coil 213, and the laser light source and detector (25) are arranged outside the magnetic shield (21) and loca...

Embodiment 2

[0045] On the basis of Embodiment 1, in the ultra-low field magnetic imaging device for living small animals in this embodiment, the stroke of the scanning stage 11 is set to 500 mm, the speed is 10 mm / s, and the positioning accuracy is 10 μm; the scanning channel 22 The diameter is 60mm; the internal central residual magnetic field of the five-layer magnetic shield 21 is less than 1nT; the material of the push rod 12 is glass, and the material of the stage 13 is plastic; the heating coil 212 maintains the internal temperature of the magnetic shield 21 at 37°C; The thermal vacuum tube 221 is a silver-plated double-layer glass vacuum tube; the atomic gas cell 24 is a glass bubble packaged with cesium atoms, and the size of the glass bubble is 1000 μl; the optical focusing lens 221 is a coated convex lens with a focal length of 50 mm.

[0046] In this embodiment, a 600pT square wave magnetic field is used to detect the magnetic field sensitivity of an ultra-low field magnetic ima...

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Abstract

The invention relates to an ultra-low field magnetic imaging device for living small animals, which belongs to the technical field of magnetic imaging, and solves the problems that an ultra-low fieldmagnetic imaging device in the prior art is complex in structure and is not suitable for large-size small animal living body scanning. The ultra-low field magnetic imaging device comprises a pushing unit and a magnetometer unit, wherein the pushing unit comprises a scanning displacement table, a push rod and an objective table; the scanning displacement table, the push rod and the objective tableare connected in sequence; the magnetometer unit comprises a magnetic shield, a scanning channel, an optical channel, an atomic gas pool, a laser source and a detector, the scanning channel penetratesthrough the side face of the magnetic shield, the atomic gas pool is arranged on one side of the scanning channel, and the laser source and a detector are arranged outside the magnetic shield and located at one end of the optical channel. The ultra-low field magnetic imaging device is simple in structure, convenient to assemble and disassemble, and suitable for large-size small animal living bodyscanning on the premise that the ultra-low field detection sensitivity is guaranteed.

Description

technical field [0001] The invention relates to the technical field of magnetic imaging, in particular to an ultra-low field magnetic imaging device for living small animals. Background technique [0002] Small animal in vivo imaging technology has gone through 20 years since the concept of in vivo imaging was proposed in 1999. It can carry out qualitative and quantitative research on the biological process in the living state at the cellular and molecular levels, by labeling cells, proteins, DNA (DeoxyriboNucleic Acid, deoxyribonucleic acid), viruses, bacteria, small molecule drugs, etc. Point observation of the growth and metabolism process of marker substances in living animals has brought significant contributions to cancer and anticancer drug research, immunology and stem cell research, early detection and treatment of diseases, new drug development and new material research. [0003] An ideal imaging method should have the characteristics of high spatial resolution, h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/055
CPCA61B5/055A61B2503/40
Inventor 姚立冯峰李起龙许敏
Owner INST OF CHEM CHINESE ACAD OF SCI
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