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Method for extracting geniposide compound from fructus gardeniae and application thereof

A technology of geniposide and water gardenia is applied in the field of medicine to achieve the effects of abundant raw materials, high purity, and development of drug value and commercial value

Inactive Publication Date: 2020-03-06
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no report on geniposide and its antihypertensive effect

Method used

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  • Method for extracting geniposide compound from fructus gardeniae and application thereof
  • Method for extracting geniposide compound from fructus gardeniae and application thereof
  • Method for extracting geniposide compound from fructus gardeniae and application thereof

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Embodiment Construction

[0013] The specific implementation of the present invention will be described in detail below in conjunction with the examples.

[0014] A kind of geniposide compound extracted from Gardenia jasminoides of the present invention is specifically implemented. 10.6 kg of Gardenia jasminoides is refluxed and extracted twice with 80 L of ethanol with a volume concentration of 95%, and the extracts are combined for 2 times for 1 hour each time. Re-suspend in 8L of water, and separate each time with 8L of petroleum ether, 8L of ethyl acetate, and 8L of n-butanol, respectively, to obtain 391.8g of petroleum ether extraction parts, 829.5g of ethyl acetate extraction parts, and n-butanol The extraction part is 724.2g; the ethyl acetate part is eluted with a CC silica gel chromatography column 12×130cm, gradient elution with 10L dichloromethane-methanol mixture, the ratios are 100:0, 100:1, 50:1, 25:1 , 12:1, 6:1, 0:1, 8 fractions A1-A8 were obtained; Fraction A6 89.3g was passed through ...

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Abstract

The invention relates to a method for extracting a geniposide compound from fructus gardeniae and an application thereof, which effectively solve the problem that a new application of fructus gardeniae geniposide and the medication for hypertension. The method comprises the following steps: carrying out reflux extraction on fructus gardeniae with ethanol with the volume concentration of 95% twice,suspending an extracting solution in water, respectively carrying out separation for five times by using petroleum ether, ethyl acetate and n-butyl alcohol, loading an ethyl acetate part obtained byseparation on a CC silica gel chromatographic column, and carrying out gradient elution by using a dichloromethane-methanol mixed solution to obtain fractions A1 to A8; enabling the fraction A6 to pass through MCI gel CHP-20CC, and carrying out gradient elution with hydrous methanol so as to obtain sub-components A6-1 to A6-5; enabling the subcomponent A6-1 to pass through silica gel CC, and carrying out gradient elution by using a dichloromethane-methanol mixture so as to obtain geniposide. The geniposide compound is rich in raw materials, the preparation method is easy to operate, the product quality is good, the purity is high, the geniposide compound can be effectively used for preparing antihypertensive drugs, the application of the geniposide compound in preparation of drugs for treating hypertension is achieved, and the drug value and commercial value of fructus gardeniae are expanded.

Description

technical field [0001] The invention relates to medicine, in particular to a method for extracting a geniposide compound from gardenia jasminoides and its application. Background technique [0002] With the gradual improvement of people's living standards and the acceleration of the pace of life, the number of hypertensive patients continues to increase every year, and appears younger. The "China Cardiovascular Disease Report 2017" shows that the number of people with hypertension in my country is about 270 million. Hypertension is the most common chronic disease and the most important risk factor for cardiovascular and cerebrovascular diseases. The current level of medical treatment can not be cured, patients can only take drugs to control. The therapeutic effect of drugs is more significant, which can reduce the chance of complications in vital organs and improve the quality of life. [0003] The occurrence of hypertension is often accompanied by excessive activation of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H1/08C07H17/04A61P9/12
CPCC07H1/08C07H17/04A61P9/12
Inventor 郑晓珂傅阳袁培培克迎迎曹彦刚张奇侯颖冯卫生
Owner HENAN UNIV OF CHINESE MEDICINE
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