Applications of flavone C-glycoside monomer compounds

A technology of flavonoid carbon glycoside monomers and compounds, which is applied in the field of medicine and can solve the problems of high preparation cost, pharmacological activity and the like

Active Publication Date: 2020-03-10
CAS CENT FOR EXCELLENCE IN MOLECULAR PLANT SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the high cost of monomer preparation, the pharmacological activities of the respective monomers of this class of compounds have not been fully explored, especially for isoorientin, which is relatively rare in nature, and no systematic research has been reported before. analgesic activity

Method used

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  • Applications of flavone C-glycoside monomer compounds
  • Applications of flavone C-glycoside monomer compounds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 Evaluation of analgesic effect in mouse acetic acid-induced pain model

[0040] Each compound (test substance) is numbered as:

[0041] A: Isovitexin; B: Orientin; C: Vitexin; D: Isorientin

[0042] Blank control (Vehicle): 2g / L physiological saline;

[0043] Positive drug: aspirin enteric-coated tablets.

[0044] After the adaptation period, 60 ICR mice were randomly divided into 6 groups, 10 in each group, and the analgesic experiment was carried out in the mouse acetic acid-induced pain model. The results are shown in Table 1.

[0045] Table 1. Embodiments of the acetic acid-induced pain model in mice

[0046]

[0047] According to Table 1, each group was given blank control or test substances A, B, C and D by intraperitoneal injection, and positive drugs were given by oral gavage. One hour after the administration, the animals were intraperitoneally injected with 0.6% acetic acid solution according to the administration volume of 10 mL / kg. Record t...

Embodiment 2

[0062] Example 2 Analgesic Effect Evaluation of Formalin Plantar Pain Model

[0063] Each compound (test substance) is numbered as:

[0064] A: Isovitexin; B: Orientin; C: Vitexin; D: Isorientin

[0065] Blank control (Vehicle): 2g / L physiological saline;

[0066] Positive drug: rotundine.

[0067] After the adaptation period, 60 mice were randomly divided into 6 groups, and 10 mice in each group were subjected to the following experiments. See Table 4.

[0068] Table 4. Analgesic implementation plan of formalin plantar pain model

[0069]

[0070] According to Table 4, each group was given blank control or test substances A, B, C and D by intraperitoneal injection, and positive drugs were given by oral gavage. One hour later, 10 μL of 1.5% formaldehyde solution was injected into the plantar of the animals. After the injection of formaldehyde solution, the animals were scored according to the following criteria within four time periods of 0-10 minutes, 10-30 minutes, ...

Embodiment 3

[0094] Embodiment 3 Evaluation of rat incision wound healing effect

[0095] Each compound (test substance) is numbered respectively:

[0096] A: Isovitexin; B: Orientin; C: Vitexin; D: Isorientin

[0097] Blank control (Vehicle): 2g / L physiological saline.

[0098] After the adaptation period, 70 rats were anesthetized by 10% chloral hydrate (300mg / kg, intraperitoneal injection), and the backs were shaved and disinfected. A wound of 2 cm in length was cut on the back of the rats with a scalpel, and photographed and recorded. Tracing the wound, using Image-Pro The software calculates the wound area. According to the wound area, 50 animals were randomly divided into 5 groups with 10 animals in each group. The results are listed in Table 6.

[0099] Table 6, rat incision wound healing evaluation embodiment

[0100]

[0101] According to Table 6, each group was given experimental rats blank control or test substances A, B, C, and D, respectively, and took pictures and c...

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Abstract

The invention discloses applications of flavone C-glycoside monomer compounds vitexin, isovitexin, orientin and isoorientin in preparation of analgesic drugs and drugs for promoting wound healing, wherein the analgesic activity of the isoorientin is remarkably higher than the analgesic activity of aspirin and rotundine, and orientin and the vitexin have strong effect of wound healing promoting.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to the application of flavone carbon glycoside monomer compounds in the preparation of analgesic drugs and the application of flavone carbon glycoside monomer compounds in the preparation of wound healing promoting drugs. Background technique [0002] Flavonoids generally refer to a series of natural products with a C6-C3-C6 structure core. According to the degree of oxidation of C3 and the substitution of functional groups, it is specifically divided into flavones, flavonols, flavanones, flavanone alcohols, isoflavones, different flavanones, chalcones, dihydrochalcones, etc. Flavone carbon glycosides refer to a special class of glycoside compounds in which the carbon atoms of the flavone core structure are directly connected to the glycosyl molecules in the form of glycosidic bonds. Flavonoid carbon glycosides have a stable structure, are less prone to be degraded than oxyglyc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D407/04A61P29/00A61P17/02
CPCA61K31/352A61P17/02A61P29/00C07D407/04A61K2300/00
Inventor 王勇陈卓孙雨伟
Owner CAS CENT FOR EXCELLENCE IN MOLECULAR PLANT SCI
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