A kind of hypothermia cerebral protection interventional catheter and preparation method thereof

A technology for interventional catheters and brain protection, applied in catheters, coatings and other directions, can solve the problems of inability to reach the low temperature level of target organs, low temperature liquid heating, affecting clinical prognosis, etc. performance effect

Active Publication Date: 2020-12-18
徐隋意
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, after vascular recanalization, a series of problems will be faced directly: such as ischemia-reperfusion (IR) injury, hemorrhagic transformation, hyperperfusion, cerebral edema, etc., which seriously affect the clinical prognosis.
[0004] The biggest problem when the interventional catheter is infused with cryogenic fluid is that the perfusate will exchange heat with the surrounding environment, which will cause the cryogenic fluid to gradually heat up and fail to reach the low temperature level required by the target organ
Since the catheter coating is made of new materials, its compatibility needs to be confirmed by a large number of clinical trials, and it is difficult to promote its use.

Method used

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  • A kind of hypothermia cerebral protection interventional catheter and preparation method thereof
  • A kind of hypothermia cerebral protection interventional catheter and preparation method thereof
  • A kind of hypothermia cerebral protection interventional catheter and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] refer to figure 1 , 2 and 3 as shown:

[0049] A method for preparing an interventional catheter for hypothermic brain protection, comprising the steps of:

[0050] (1) The common hypothermic cerebral protection interventional catheter is pretreated with absolute ethanol:

[0051] Soak in anhydrous ethanol for 20min and sonicate, take out and air dry at room temperature;

[0052] (2) Get the chitosan material, dissolve it with a weak acid, put the catheter and the solution after the pretreatment of step (1) into a hollow mold together for injection molding, molding, neutralization, fixing, cleaning, and freeze-drying to obtain Catheters with an inner layer of porous structure:

[0053] The chitosan was dissolved with 8% acetic acid to obtain a 5% chitosan solution. Then inject the catheter and the solution into the mold. After preforming by freezing at -80°C, the catheter is withdrawn from the mold and placed in a 0.8% sodium carbonate solution. After neutralizing ...

Embodiment 2

[0060] The difference between this embodiment and embodiment 1 is only that: the superabsorbent resin is grafted acrylamide; the biocompatible outer layer is L-polylactic acid (L-PLA).

Embodiment 3

[0062] The difference between this embodiment and embodiment 1 is that: the superabsorbent resin is cross-linked carboxymethyl cellulose with a high degree of substitution; the outer layer of biocompatibility is polycaprolactone (PCL).

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Abstract

The invention relates to the technical field of preparation of medical interventional catheters, in particular to a low-temperature brain protection interventional catheter and a preparation method thereof. According to the low-temperature brain protection interventional catheter, a cavity for conveying a low-temperature liquid is formed in a catheter, an outer coating of the catheter sequentiallycomprises an inner layer of a porous structure, a super absorbent resin layer for water absorption and a biocompatible outer layer from inside to outside. According to the catheter, the problem of temperature rise caused by heat exchange in the conveying process of a low-temperature liquid is solved, and the liquid is controlled to a proper treatment temperature, moreover, the coating is stable in structure, the structure between the coatings is compact, the thickness of the coating is not remarkably increased, and the biocompatibility of all the coatings in the application process is good.

Description

technical field [0001] The invention relates to the technical field of preparation of medical interventional catheters, in particular to a low-temperature brain protection interventional catheter and a preparation method thereof. Background technique [0002] Rescuing the penumbra within the treatment time window is an eternal topic in the acute phase management of ischemic stroke, and the most important principle is to achieve early vascular recanalization. On the basis of thrombolytic therapy, the "five major studies" of endovascular therapy in recent years, especially the DAWN and DIFFUSE 3 studies, have brought about the spring of mechanical thrombectomy and rewritten the treatment guidelines for acute ischemic stroke in 2018. However, after vascular recanalization, it will directly face a series of problems: such as ischemia-reperfusion (IR) injury, hemorrhagic transformation, hyperperfusion, cerebral edema, etc., which seriously affect the clinical prognosis. Aiming a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M25/00A61L29/12A61L29/04A61L29/06A61L29/14A61L29/16
CPCA61L29/041A61L29/043A61L29/06A61L29/14A61L29/146A61L29/16A61L2300/41A61L2300/416A61L2300/42A61M25/0009A61M25/0045C08L33/26C08L67/04C08L5/08
Inventor 徐隋意李常新吴晓巍李羚
Owner 徐隋意
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