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Extraction and separation method of glabridin

A technology of glabridin and a separation method, which is applied in the field of separation and purification, can solve the problems of silica gel reuse, unfriendly environment, and difficult cost control, and achieve the effects of low cost, solvent saving, and less impurities

Inactive Publication Date: 2020-03-27
辰风天然本草(北京)科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent uses silica gel chromatography, ethyl acetate, petroleum ether and other solvents, which are less safe and environmentally unfriendly. At the same time, the amount of solvent required for silica gel chromatography is large, and the reuse of silica gel is a big problem, and the cost is difficult to control.

Method used

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  • Extraction and separation method of glabridin

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Effect test

Embodiment 1

[0028]A method for extracting and separating high-purity glabridin from licorice residue by using a single solvent, using licorice residue as raw material, using ethanol for normal temperature sleeve extraction, coarse separation of macroporous adsorption resin, fine separation of polymer chromatography filler, and crystallization of ethanol According to the technological process, more than 95% of the glabridin product can be obtained at last.

[0029] (1) extraction

[0030] Take 30kg of dried licorice residue and put it into a 500L stainless steel extraction tank for the first extraction, add 210L of 90% ethanol, soak for 3 hours, and cycle for 5 minutes every 30 minutes. After the first extraction, separate the first extraction solution, the residue Then use 210L of 90% ethanol for the second extraction, soak at room temperature for 3 hours, and beat for 5 minutes every 30 minutes. Separate the extracting solution for the second time and use it for the next extraction. The...

Embodiment 2

[0038] (1) extraction

[0039] Take 30kg of dried licorice raw material and put it into a 500L stainless steel extraction tank for the first extraction, add 210L 80% ethanol, soak for 3hrs, and cycle for 5min every 30min. Use 210L of 80% ethanol for the second extraction, soak at room temperature for 3 hours, and beat for 5 minutes every 30 minutes. Separate the extracting solution for the second time and use it for the next extraction. The extracting solution for the second time is added to 30 kg of new licorice dregs to extract for the first time, and the extraction method is the same as above. 186L of separated cap extract solution enters the concentration process. Concentrate to 1 / 7 of the original volume, about 26L, adjust the ethanol concentration of the concentrated solution to 50%, and obtain 30L liquid, which is to be loaded on a macroporous adsorption resin ADS-17 column.

[0040] (2) Macroporous adsorption resin adsorption

[0041] 30L of concentrated solution is...

Embodiment 3

[0047] (1) extraction

[0048] Take 30 kg of dried licorice residue raw material and put it into a 500L stainless steel extraction tank for the first extraction, add 210L of 70% ethanol, soak for 3 hours, and cycle for 5 minutes every 30 minutes. Use 210L of 70% ethanol for the second extraction, soak at room temperature for 3 hours, and beat for 5 minutes every 30 minutes. Separate the extracting solution for the second time and use it for the next extraction. The extracting solution for the second time is added to 30 kg of new licorice dregs to extract for the first time, and the extraction method is the same as above. 185L of the separated cap extract liquid enters the concentration process. Concentrate to 1 / 7 of the original volume, about 26L, adjust the ethanol concentration of the concentrated solution to 50%, to obtain 30L liquid, to be loaded on a macroporous adsorption resin D101 column.

[0049] (2) Macroporous adsorption resin adsorption

[0050] 30L concentrated...

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Abstract

The invention relates to an extraction and separation method of glabridin. According to the extraction and separation method, normal-temperature extraction is adopted, in the separation process, macroporous resin pretreatment is adopted to obtain crude total flavonoids, polymer chromatographic packing material fine separation is adopted, most of other flavonoids can be effectively removed, an obtained glabridin crude product is high in content, and 90% or above of glabridin product can be obtained through ethyl alcohol recrystallization. According to the extraction and separation method, onlyone organic solvent ethanol is used all the time, the process route is simple, no environment-friendly solvent is used in the preparation process, the cost is low, and the method is suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of separation and purification, in particular to a method for extracting and purifying high-purity glabridin from the dregs of the glabra medicinal material or glabridin medicinal material after water extraction. Background technique [0002] Glabridin is a flavonoid extracted from Glycyrrhiza glabra with molecular formula C 20 h 20 o 4 , the molecular weight is 324.36. It is currently the most effective and safest natural whitening additive in the cosmetics industry, known as whitening gold. At the same time, glabridin also has the functions of anti-oxidation, anti-inflammation, anti-atherosclerosis, regulation of energy metabolism, neuroprotection, and anti-osteoporosis. In 2011, EU regulations authorized the release of licorice flavonoid products containing glabridin as new food ingredients on the market. But at present, due to the extremely high production cost of glabridin, the price of glabridin i...

Claims

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Application Information

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IPC IPC(8): C07D493/04
CPCC07D493/04
Inventor 吴启林孟令超叶洪波
Owner 辰风天然本草(北京)科技有限公司
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