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Multi-functional antioxidation magnetic nanocomposite material and preparation method thereof

A nanocomposite material, magnetic nanotechnology, applied in the field of nanobiomedical materials, can solve the problems of low utilization rate, difficult to achieve precise targeted delivery, etc., achieve good biocompatibility, achieve precise targeted delivery, and easy clinical application Effect

Active Publication Date: 2020-03-31
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, many nanozymes with inherent enzymatic activity have been developed for antioxidant research, showing good pharmacokinetics and microenvironmental tolerance, but there are still problems such as difficulty in precise targeted delivery and low utilization.

Method used

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  • Multi-functional antioxidation magnetic nanocomposite material and preparation method thereof
  • Multi-functional antioxidation magnetic nanocomposite material and preparation method thereof
  • Multi-functional antioxidation magnetic nanocomposite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Weigh 0.7g (35mg / mL) of ferric chloride hexahydrate, 100mg (5mg / mL) of lignin, and 1.8g (90mg / mL) of sodium acetate and dissolve them in 20mL of ethylene glycol, and seal the resulting mixed solution in a 50mL reaction vessel , reacted at 200°C for 10 h, and washed thoroughly with N,N-dimethylformamide and distilled water to obtain a nanocomposite material.

[0030] figure 1 , figure 2 They are the TEM image, the hydrated particle size and the surface potential test image of the nanocomposite material prepared in this example, respectively. Depend on figure 1 , figure 2 It can be seen that the prepared nanocomposite material presents the morphology of nanoclusters, the hydrated particle size is about 304nm, and the surface potential is about -20mV.

[0031] image 3 Test charts of the free radical scavenging rate of the nanocomposite prepared in this example at different concentrations. Depend on image 3 It can be seen that with the increase of concentration, ...

Embodiment 2

[0035]Weigh ferric chloride hexahydrate 0.2g (10mg / mL), lignin 200mg (10mg / mL), sodium acetate 1g (50mg / mL) and dissolve in 20mL ethylene glycol, and the formed mixed solution is sealed in a 50mL reactor , reacted at 180 ℃ for 8h, and obtained the nanocomposite material after thorough washing with N,N-dimethylformamide and distilled water.

Embodiment 3

[0037] Weigh ferric chloride hexahydrate 0.4g (20mg / mL), lignin 300mg (15mg / mL), sodium acetate 1.4g (70mg / mL) and dissolve in 20mL ethylene glycol, and the formed mixed solution is sealed in a 50mL reactor The nanocomposite was obtained after the reaction was carried out at 190 °C for 9 h, and the nanocomposite was obtained after thorough washing with N,N-dimethylformamide and distilled water. After testing, the SAR value of the nanocomposite is 879W / g.

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Abstract

The invention relates to a multi-functional antioxidation magnetic nanocomposite material and a preparation method thereof. The nanocomposite material is a lignin-ferrite nanocomposite material whichis synthesized in one step through a simple solvothermal method by using ferric chloride hydrated and natural polymer as raw materials. Compared with a prior art, the nanocomposite material manufactured by the preparation method has excellent inoxidizability and magnetic properties, and also has favourable biocompatibility, so that functions of active radical removing, physiotherapy based on a magnetic field, magnetic resonance imaging and the like can be integrally combined, and the nanocomposite material has wide application prospects in the respect of oxidative stress relevant disease treatment; and in addition, based on the excellent magnetic driving properties of nanocomposite material, the nanocomposite material also has tremendous application potential in the fields of magnetic driving motor, drug pinpoint delivery and the like.

Description

technical field [0001] The invention belongs to the technical field of nano biomedical materials, and relates to a multifunctional anti-oxidation magnetic nano composite material and a preparation method thereof. Background technique [0002] A large number of studies have shown that the oxidative stress response caused by the imbalance between the production of active free radicals and antioxidant defense in the body is related to the occurrence and process of various diseases, including aging, autoimmune diseases (such as type 1 diabetes, class 1 diabetes, etc.) Rheumatoid arthritis), cardiovascular diseases (such as atherosclerosis) and neurodegenerative diseases (such as Parkinson's disease, Alzheimer's disease), etc. Therefore, antioxidant therapy is recognized as a potential means to prevent and treat oxidative stress-related diseases. So far, a variety of small molecule antioxidants including vitamin E and catechol have been approved by the FDA for antioxidant therap...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61P39/06
CPCA61K41/0052A61P39/06
Inventor 成昱李珍光
Owner TONGJI UNIV