A kind of intelligent dressing and its preparation method

An intelligent, dye-based technology, applied in dressings, viscous dressings, medical science, etc., can solve the problems of unfavorable wound recovery, accelerated wound infection, etc., and achieve the effect of avoiding serious infection and good application prospects

Active Publication Date: 2022-04-22
河南驼人医疗器械研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If such a high pH condition cannot be diagnosed and treated in time, it will accelerate the infection of the wound and is not conducive to the recovery of the wound.

Method used

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  • A kind of intelligent dressing and its preparation method
  • A kind of intelligent dressing and its preparation method
  • A kind of intelligent dressing and its preparation method

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Experimental program
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Effect test

preparation example Construction

[0044] The present invention also provides a preparation method of the smart dressing described in the above technical solution, comprising the following steps:

[0045] a) After mixing the alginate solution and the polyethylene oxide solution, sequentially add a dispersant and a dye-loaded silicon dioxide nanoparticle solution, stir evenly and let it stand for defoaming to obtain a spinning solution; Electrospinning to obtain an alginate spinning membrane; then place the alginate spinning membrane in a calcium chloride solution for cross-linking, then wash and dry to obtain an alginate / polyoxyethylene composite fiber membrane , to form a pH sensor unit after tailoring;

[0046] b) fixing the pH sensor unit obtained in step a) on a transparent dressing patch, and then covering the wound with a contact dressing to obtain a smart dressing.

[0047] In the invention, after mixing the alginate solution and the polyethylene oxide solution, the dispersant and the dye-loaded silicon...

Embodiment 1

[0059] (1) Stir and dissolve 4g alginate in 96mL deionized water to obtain alginate solution; stir and dissolve 4g polyethylene oxide in 96mL deionized water to obtain polyethylene oxide solution; then mix 40g alginate solution and 60g The polyethylene oxide solution was mixed and stirred, then 0.5 mL of glycerin and 5 mL of DMSO were added, and then 0.4286 g of a dye-loaded silica nanoparticle solution with a mass concentration of 7% was added, stirred evenly and left to stand for defoaming for 20 hours to obtain a spinning solution.

[0060] (2) Use electrospinning equipment to carry out electrospinning to the spinning solution obtained in step (1), adjust the positive voltage of the electrospinning machine to be 18kV, the negative voltage to be -5kV, the receiving distance to be 12cm, and the liquid output speed to be 1.2mL / h, to obtain alginate spinning membrane.

[0061] (3) placing the alginate spun membrane obtained in step (2) in a calcium chloride solution with a ma...

Embodiment 2

[0066] (1) Stir and dissolve 4g alginate in 96mL deionized water to obtain alginate solution; stir and dissolve 4g polyethylene oxide in 96mL deionized water to obtain polyethylene oxide solution; then mix 50g alginate solution and 50g The polyethylene oxide solution was mixed and stirred, then 0.5 mL of glycerin and 5 mL of DMSO were added, and then 0.4286 g of a dye-loaded silica nanoparticle solution with a mass concentration of 7% was added, stirred evenly and left to stand for defoaming for 20 hours to obtain a spinning solution.

[0067] (2) Use electrospinning equipment to carry out electrospinning to the spinning solution obtained in step (1), adjust the positive voltage of the electrospinning machine to be 18kV, the negative voltage to be -5kV, the receiving distance to be 12cm, and the liquid output speed to be 1.2mL / h, to obtain alginate spinning membrane.

[0068] (3) placing the alginate spun membrane obtained in step (2) in a calcium chloride solution with a mass...

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Abstract

The invention provides an intelligent dressing, comprising: a transparent dressing patch; a pH sensor unit fixed on the transparent dressing patch; a wound contact dressing covered on the pH sensor unit; the pH sensor unit is composed of a load Silica nanoparticles of dyes are blended with alginate and polyethylene oxide and then electrospun. Compared with the prior art, the intelligent dressing provided by the present invention achieves nano-encapsulation of dyes through silica nanoparticles loaded with dyes, and obtains a pH sensor unit. On the basis of meeting the requirements of wound care, it can monitor wound pH changes in real time and feedback Wound infection information helps to take rapid and timely treatment, thereby avoiding severe wound infection, and has a good application prospect in wound dressing.

Description

technical field [0001] The invention relates to the technical field of dressings, and more specifically relates to an intelligent dressing and a preparation method thereof. Background technique [0002] In daily life, people often encounter various injuries, which are caused by physical, chemical, thermal, mechanical, pressure, infection, disease and other factors, resulting in skin defects. A key defect of traditional dressings is that they cannot provide instant wound-related information. Changes in the wound microenvironment include pH, temperature, bacterial load, tissue oxygen content, and inflammation levels. Therefore, the new generation of wound dressings can no longer be limited to simple protection, hemostasis or absorption of wound exudate, but should be a type of intelligent dressing that integrates multiple functions, which can instantly feed back important information inside the wound, so that Speed ​​up the wound care decision-making process and reduce freque...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F13/02A61F13/00A61L15/18A61L15/26A61L15/28A61L15/42
CPCA61F13/02A61F13/00059A61F13/0276A61L15/26A61L15/42A61L15/18A61L15/28
Inventor 程杰崔景强王国锋李艳群王幸幸李嘉嘉桂鑫程静静田静翟胜娜夏怡琳李丹杰
Owner 河南驼人医疗器械研究院有限公司
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