Composite sea cucumber extract with hypoglycemic activity and preparation method and application thereof

A technology for lowering blood sugar and extracts, which is applied in the field of compound sea cucumber extracts and its preparation, can solve the problems of cumbersome extraction process, long time consumption, unclear species of sea cucumber, etc., and achieve simple extraction process, lower viscosity, and good blood sugar lowering effect Effect

Active Publication Date: 2020-04-10
SOUTH CHINA UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Existing research (patent CN103110659A, the application of sea cucumber sulfate polysaccharide in the preparation of anti-type 2 diabetes drugs or products) has discussed the application of sea cucumber sulfate polysaccharide in improving or treating type 2 diabetes, wherein sea cucumber chondroitin sulfate and fucoidan sulfate Esters are commercially available or extracted separately, but there are problems such as unclear species of sea cucumber, cumbersome and time-consuming extraction process, and lack of compounding of sea cucumber polysaccharides with different structures in the research.

Method used

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  • Composite sea cucumber extract with hypoglycemic activity and preparation method and application thereof
  • Composite sea cucumber extract with hypoglycemic activity and preparation method and application thereof
  • Composite sea cucumber extract with hypoglycemic activity and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0044] This embodiment provides a compound sea cucumber extract with hypoglycemic activity, and its preparation method specifically includes the following steps:

[0045] (1) Mixing dried sea cucumbers: using dried plum-flowered ginseng and dried leaf-melon ginseng as raw materials, the mass ratio of the dried plum-flowered ginseng and dried leaf-melon ginseng is 3:2;

[0046] (2) Soaking in warm water: Soak the dried sea cucumber obtained in step (1) with warm water, the amount of deionized water added is 20 times the mass of the dried sea cucumber, the water temperature is 50°C, and the soaking time is 8 hours; the addition of deionized water for cleaning the sea cucumber The amount is 20 times the mass of dry sea cucumbers, the water temperature is 40°C, the soaking and washing time is 20 minutes, and the number of washings is 2 times to obtain wet sea cucumbers;

[0047] (3) mincing: the wet sea cucumber obtained in step (2) is minced to obtain minced sea cucumber;

[004...

Embodiment 2

[0056] This embodiment provides a compound sea cucumber extract with hypoglycemic activity, and its preparation method specifically includes the following steps:

[0057] (1) Mixing dried sea cucumbers: using dried plum-flowered ginseng and dried leaf-melon ginseng as raw materials, and the mass ratio of the dried plum-flowered ginseng and dried leaf-melon ginseng is 2:3.

[0058] (2) Soaking in warm water: Soak the dried sea cucumber obtained in step (1) with warm water, the amount of deionized water added is 25 times the mass of the dried sea cucumber, the water temperature is 55°C, and the soaking time is 9 hours; the addition of deionized water for cleaning the sea cucumber The amount is 25 times the mass of dry sea cucumbers, the water temperature is 45°C, the soaking and washing time is 25 minutes, and the number of washings is 3 times to obtain wet sea cucumbers;

[0059] (3) mincing: the wet sea cucumber obtained in step (2) is minced to obtain minced sea cucumber;

...

Embodiment 3

[0068] This embodiment provides a compound sea cucumber extract with hypoglycemic activity, and its preparation method specifically includes the following steps:

[0069] (1) Mixing dried sea cucumbers: using dried plum-flowered ginseng and dried leaf-melon ginseng as raw materials, and the mass ratio of the dried plum-flowered ginseng and dried leaf-melon ginseng is 1:4.

[0070] (2) Soaking in warm water: Soak the dried sea cucumbers obtained in step (1) with warm water, the amount of deionized water added is 30 times the mass of dried sea cucumbers, the water temperature is 60°C, and the soaking time is 10 hours; the addition of deionized water for cleaning sea cucumbers The amount is 30 times the mass of dry sea cucumbers, the water temperature is 50°C, the soaking and washing time is 30 minutes, and the number of washings is 4 times to obtain wet sea cucumbers;

[0071] (3) mincing: the wet sea cucumber obtained in step (2) is minced to obtain minced sea cucumber;

[007...

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Abstract

The invention discloses a composite sea cucumber extract with hypoglycemic activity and a preparation method and application thereof. The method comprises the following steps: mixing two types of low-edible-value dry sea cucumbers used as raw materials in a proportion, soaking the sea cucumbers in warm water, performing mincing, adding water for enzymolysis, performing high-temperature acid extraction, performing ultrafiltration to remove impurities, performing graded alcohol precipitation, performing precipitation redissolution, performing reduced-pressure concentration, and finally performing freeze drying to obtain the composite sea cucumber extract with a hypoglycemic effect. The polysaccharide substance content of the extract is greater than 30%, the sulfate group content is greater than 10%, and the extract has a good hypoglycemic effect on the animal level. The extraction technology is simple, the whole technological process can meet the food-grade requirement, and the sea cucumber extract can be applied to the fields of medicines, health care products, food and the like.

Description

technical field [0001] The invention belongs to the field of sea cucumber deep processing and high value, and specifically relates to a compound sea cucumber extract with hypoglycemic activity and its preparation method and application. Background technique [0002] Diabetes is a chronic systemic metabolic disease related to genetic factors and various environmental factors. Type 2 diabetes is the most complex and has the highest prevalence rate, accounting for more than 90% of the patients in my country. At present, there are about 110 million diabetic patients in my country, which is the country with the largest number of diabetic patients in the world. Therefore, the development of health food and medicines with hypoglycemic activity and no side effects has significant social and economic benefits. [0003] Sea cucumber is an important resource for both medicine and food in the ocean. It ranks first among the eight treasures of the sea. There are approximately 1,250 spe...

Claims

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Application Information

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IPC IPC(8): A61K35/616A61P3/10A23L33/00
CPCA61K35/616A61P3/10A23L33/00A23V2002/00A61K2300/00A23V2200/328
Inventor 林恋竹朱启源赵谋明
Owner SOUTH CHINA UNIV OF TECH
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