The invention discloses a method for extracting fructus cannabis oligopeptide from fructus cannabis cake meal. The method particularly comprises the following steps: collecting fructus cannabis cake meal with grease content being less than 1%, adding water, adjusting the pH to 9.0, adding sodium metabisulfite, performing solid-liquid separation and collecting liquid phase; adding a HCl solution into the liquid phase, adjusting the pH to 3.8 to 4.3, standing, performing solid-liquid separation for the second time and collecting precipitate; adding water, heating to 40 to 55 DEG C, adjusting thepH to 7.0 to 9.0, adding composite protease, performing enzymolysis for 3 to 6 hours, performing centrifugal filtration and collecting clear liquid, namely a fructus cannabis oligopeptide solution; performing electroosmosis, concentrating and freeze-drying to obtain the fructus cannabis oligopeptide powder. The fructus cannabis oligopeptide is obtained by taking the fructus cannabis cake meal, which is squeezed to remove oil, as a raw material with reference to an isoelectric point principle and protein precipitation, and according to the methods for performing enzymolysis by the composite protease and freeze-drying. In the whole process, a pure physical process is utilized, chemical components are not added basically, the cost is low, and environmental pollution is avoided.