The present invention relates to special medical use infant formula milk powder. The special medical use infant formula milk powder comprises the following raw materials in weight percentages: lactose-free whole milk powder, isolated whey protein WPI, solid corn syrup, plant fat powder, nucleotide, arachidonic acid, docosahexaenoic acid, vitamins and a mineral premix. A formula is as follows: producing 1 ton of the product requires the following accessory materials: 150 kg of lactose-free whole milk powder, 70 kg of isolated whey protein WPI, 326 kg of solid corn syrup, 400 kg of plant fat powder, 1.2 kg of nucleotides, 8.6 kg of arachidonic acid, docosahexaenoic acid, 36 kg of vitamins and a mineral premix. The special medical use infant formula milk powder uses a lactose-free formula andhas a lactose content less than 0.5%, lactose indigestion may cause diarrhea, flatulence, crying and screaming, etc., the lactose-free formula can reduce the diarrhea, flatulence, crying and screaming, etc. caused by lactose intolerance, and the lactose-free milk powder can reduce intestinal digestive burden, is conducive to diarrhea recovery and can avoid the lactose intolerance.