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Hemostatic material and wound dressing material containing same

A technology for hemostatic materials and wound dressings, applied in the field of hemostatic materials and wound dressings, can solve problems such as the production of dioxins, and achieve the effect of promoting healing and high safety.

Inactive Publication Date: 2020-04-10
医疗发明株式会社 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, disposal is carried out by incineration or landfill, but if the temperature of the combustion furnace drops during incineration, dioxin may be generated

Method used

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  • Hemostatic material and wound dressing material containing same
  • Hemostatic material and wound dressing material containing same
  • Hemostatic material and wound dressing material containing same

Examples

Experimental program
Comparison scheme
Effect test

Synthetic example 1

[0047] Synthesis of Chloro-2-Hydroxy-3-Trimethylaminopropyl Cellulose

[0048] To a solution obtained by dissolving cellulose (1.0 g) in 20 mL of 1N aqueous sodium hydroxide solution, 3-chloro-2-hydroxypropyltrimethylammonium chloride (2.3 g) was added as a cationizing agent, and the Stirring was carried out at ~50°C. The resulting solution was neutralized with 4N acetic acid, and then separated through a dialysis membrane with distilled water. The resulting solution was freeze-dried to obtain the target product.

Synthetic example 2

[0050] Synthesis of Chlorinated-6-Hydroxyethyl-(2-Hydroxy-3-trimethylaminopropyl) Cellulose

[0051] Hydroxyethylcellulose was synthesized by reacting cellulose (2.0 g) with ethylene oxide under known conditions. To a solution obtained by dissolving the obtained hydroxyethyl cellulose in 20 mL of 1N aqueous sodium hydroxide solution, add glycidyltrimethylammonium chloride (4.5 g) as a cationizing agent, and stir at 30 to 50°C . The resulting solution was neutralized with 4N acetic acid, and then separated through a dialysis membrane with distilled water. The resulting solution was freeze-dried to obtain the target product.

[0052] Cationized cellulose having different types of substituents can be synthesized by the same method as in the above-mentioned synthesis examples. As for the solvent and the like to be used, alcohols such as methanol and ethanol, acetonitrile and the like may be added depending on the solubility of the substrate. The equivalent of the cationizing a...

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Abstract

The purpose of the present invention is to provide: a hemostatic material which eliminates the risks characteristic of conventional chitosan-derived products such as endotoxin contamination and triggering of shellfish allergy, can be safely used on more people, and has antibiotic properties and hemostatic effects that widely-used hydrogels do not have; and a wound dressing material containing thesame. Provided are a hemostatic agent containing a cationized cellulose and a wound dressing material containing the same. At least one hydroxyl group of the cationized cellulose is modified with -R2-N+(R3)(R4)(R5).X-, and the other hydroxyl groups of the cationized cellulose have -H or -(CH2CH2O)m-H, where R2 is C1-6 alkylene, C2-6 hydroxyalkylene, -(CH2CH2O)l- or a combination thereof, and l is1 or 2, m is 1 or 2, and X- may be an anionic group.

Description

technical field [0001] The invention relates to a hemostatic material and a wound dressing containing the hemostatic material. Background technique [0002] As the mechanism of skin wound healing, it is known that (1) after skin injury, platelets gather in the wound to coagulate the blood to stop the bleeding; (2) neutrophils and macrophages gather around the wound to phagocytize and remove necrotic tissue and bacteria ; (3) Fibroblasts gather to shrink the wound; (4) Epidermal cells migrate and gather to epithelialize the wound. [0003] Wound healing requires such various living cells to gather and function in the wound. In order to heal a wound, a large number of cytokines represented by growth factors induce desired cells to the wound. In order to heal wounds quickly, it is important to maintain an environment in which cells gathered to the wound by cytokines can actively act. [0004] The idea that the wound should be dried in order to heal the wound has been mainstr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28
CPCA61L24/08A61L24/0015A61L15/28A61L15/44A61L15/46A61L2300/418A61L2400/04A61L2300/404A61L2300/232C08L1/02C08L1/00C08B15/06
Inventor 柴田和彦
Owner 医疗发明株式会社
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