Enconazole external liquid preparation and preparation method thereof

A liquid preparation, the technology of enconazole, applied in the field of external liquid preparation of enconazole and its preparation, can solve the problems of drug resistance and affecting the therapeutic effect, and achieve the effect of no skin irritation, obvious itching, and good antibacterial effect

Inactive Publication Date: 2020-04-17
武汉回盛生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are few medicated baths for the treatment of canine fungal skin in China, and miconazole lotion is used more often. Long-term use is prone to drug resistance and affects the therapeutic effect

Method used

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  • Enconazole external liquid preparation and preparation method thereof
  • Enconazole external liquid preparation and preparation method thereof
  • Enconazole external liquid preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A liquid preparation for external use of enconazole, comprising the following components: 100g of enconazole, 200g of Tween 20, 250g of Span 80, 100g of ethanol, 120g of glycerol, 10g of menthol and the remainder of propylene glycol ; Wherein, the particle size of enconazole is 60 mesh.

[0026] The preparation method of the above-mentioned enconazole liquid preparation for external use is: dissolving menthol in ethanol, then adding enconazole, Tween 20, Span 80, and glycerol at a temperature of 25°C and a stirring speed of 500rpm / min Stir at low temperature for 10 minutes, then add propylene glycol to dilute to 1 L to obtain a liquid preparation.

Embodiment 2

[0028] A liquid preparation for external use of enconazole, comprising the following components: 100g of enconazole, 250g of Tween 80, 200g of Span 20, 100g of ethanol, 100g of glycerol, 15g of menthol and the remainder of propylene glycol ; Wherein, the particle size of enconazole is 70 mesh.

[0029] The preparation method of the above-mentioned enconazole liquid preparation for external use is: dissolving menthol in ethanol, then adding enconazole, Tween 80, Span 20, and glycerol at a temperature of 28°C and a stirring speed of 800rpm / min Stir at low temperature for 20 minutes, then add propylene glycol to dilute to 1 L to obtain a liquid preparation.

Embodiment 3

[0031] A liquid preparation for external use of enconazole, comprising the following components: 150g of enconazole, 250g of Tween 20, 200g of Span 20, 150g of ethanol, 150g of glycerol, 20g of menthol and the rest of Propylene glycol; Wherein, the particle diameter of enconazole is 80 orders.

[0032] The preparation method of the above-mentioned enconazole liquid preparation for external use is as follows: dissolve menthol in ethanol, then add enconazole, Tween 20, Span 20, and glycerin at a temperature of 28°C and a stirring speed of 900rpm / min Stir at low temperature for 20 minutes, then add propylene glycol to dilute to 1 L to obtain a liquid preparation.

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Abstract

The invention provides an enconazole external liquid preparation, which is prepared by mixing enconazole, a solvent capable of dissolving enconazole and an emulsifier, and tests show that the appearance, the pH value and the purity of the enconazole external liquid preparation are basically unchanged after three months, so that the enconazole external liquid preparation can stably exist and is noteasy to degrade; the enconazole external liquid preparation disclosed by the invention can be used for effectively treating canine fungal skin diseases, and is simple in use method and good in antibacterial effect; the enconazole external liquid preparation disclosed by the invention contains menthol, and the external liquid preparation added with menthol has a relatively obvious relieving effecton discomfort, such as pruritus, of some pets when being used for treating fungal skin diseases; the enconazole external liquid preparation provided by the invention is mild to dogs and has no irritation to skin.

Description

technical field [0001] The invention relates to the technical field of veterinary pharmaceutical preparations, in particular to a liquid preparation of enconazole for external use and a preparation method thereof. Background technique [0002] Dog skin disease is one of the diseases with high clinical incidence in my country at present, especially fungal skin disease, which has a large number of clinical admissions, is common, and is a zoonotic disease. Canine fungal dermatosis is a large class of diseases of skin appendages such as skin, mucous membranes, hair and nails caused by fungal infection. It is a superficial fungal infection disease in which dermatophytes invade the epidermis. Canine fungal dermatosis not only affects the appearance, growth and development of the dog itself, but pathogenic bacteria can also infect people and threaten human health, so the treatment of canine fungal dermatosis is particularly important. [0003] At present, domestically, oral admini...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/4174A61P31/10A61P17/00A61K47/10A61K47/26A61K47/14A61P17/04
CPCA61K9/0014A61K9/08A61K31/4174A61K47/10A61K47/14A61K47/26A61P17/00A61P17/04A61P31/10
Inventor 张卫元刘洁成梦雅陈向丹陈骁李硕郑春红
Owner 武汉回盛生物科技股份有限公司
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