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A kind of injectable and self-healing starch-based hydrogel and its preparation method and application

A composite hydrogel, starch-based technology, applied in the field of starch materials, can solve the problems of cell proliferation and differentiation, negative effects on human health, etc., and achieve the effects of strong mechanical properties, simple process, and good fluidity.

Active Publication Date: 2021-11-12
天津塑醒材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the chemical organic cross-linking agent is adsorbed in the three-dimensional structure of the hydrogel, which has a negative impact on the proliferation and differentiation of cells and the health of the human body.

Method used

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  • A kind of injectable and self-healing starch-based hydrogel and its preparation method and application
  • A kind of injectable and self-healing starch-based hydrogel and its preparation method and application
  • A kind of injectable and self-healing starch-based hydrogel and its preparation method and application

Examples

Experimental program
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preparation example Construction

[0041] The present invention provides the preparation method of above scheme injectable and self-healing starch-based hydrogel, comprising the following steps:

[0042] (1) The polyvinyl alcohol, water and Laponite charged nanoparticles are first mixed at 95-100°C, and then cooled to room temperature to obtain Laponite / PVA hydrogel;

[0043] (2) performing the second mixing of the Laponite / PVA hydrogel and starch aqueous solution at 95-100°C, and then cooling to room temperature to obtain a starch-based composite hydrogel;

[0044] (3) drying the starch-based composite hydrogel to a water content of 30-70 wt%, to obtain the injectable and self-healing starch-based hydrogel.

[0045] In the invention, polyvinyl alcohol, water and Laponite charged nanoparticles are first mixed under the condition of 95-100 DEG C, and then cooled to room temperature to obtain Laponite / PVA hydrogel. In the present invention, the first mixing method is specifically: mixing polyvinyl alcohol and wa...

Embodiment 1

[0053] The reagents used in Example 1 are all commercially available.

[0054] Dissolve 4g of polyvinyl alcohol (PVA) in water at a high temperature of 95°C to obtain a PVA aqueous solution with a concentration of 0.5g / mL;

[0055] Use ultrasonic dispersion to disperse 1g of Laponite charged nanoparticles in the above-mentioned PVA aqueous solution at a high temperature of 95°C, and cool to room temperature to obtain Laponite / PVA hydrogel for use; the frequency of ultrasonic dispersion is 40kHz, and the dispersion is continuous for 3 times, each time 30s, Each interval is 10s;

[0056] Add the above-mentioned Laponite / PVA hydrogel into an aqueous solution of cationic cornstarch with a concentration of 1g / mL, the mass of cationic cornstarch is 5g, blend with a stirring paddle at a speed of 60rpm at a high temperature of 95°C for 30min, cool to room temperature, and obtain starch The starch-based composite hydrogel; the internal moisture content of the starch-based composite hy...

Embodiment 2

[0061] All reagents used in Example 2 are commercially available.

[0062] Dissolve 1g of polyvinyl alcohol (PVA) in water at a high temperature of 95°C to obtain a PVA aqueous solution with a concentration of 0.05g / mL;

[0063] Use ultrasonic dispersion to disperse 2g of Laponite charged nanoparticles in the above-mentioned PVA aqueous solution at a high temperature of 95°C, and obtain Laponite / PVA hydrogel for use after cooling to room temperature; Interval 10s;

[0064] Add the above-mentioned Laponite / PVA hydrogel to the aqueous solution of tapioca starch with a concentration of 0.1g / mL, the mass of tapioca starch is 7g, blend the stirring paddle at a speed of 80rpm at a high temperature of 95°C for 30min, and cool to room temperature to obtain starch-based composite water Gel; the internal moisture content of the starch-based composite hydrogel was adjusted to 50wt% by an oven at 60°C to obtain an injectable and self-healing starch-based hydrogel.

[0065] The scanning ...

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Abstract

The invention provides an injectable and self-healing starch-based hydrogel, its preparation method and application, and relates to the technical field of starch materials. The hydrogel provided by the present invention is prepared from raw materials comprising the following components: solid phase components and water; the solid phase components comprise the following components in mass percentages: 40% to 94% of starch, 5% of polyvinyl alcohol -40% and Laponite charged nanoparticles 1-20%; the water content of the injectable and self-healing starch-based hydrogel is 30-70wt%. The injectable and self-healing starch-based hydrogel provided by the invention does not need to add any catalyst, initiator or cross-linking agent, is non-toxic and non-irritating, and can be applied in the fields of bone tissue repair and controlled drug release. The invention provides the preparation method of the hydrogel, which does not require means such as ultraviolet rays or radiation, and has simple processes and easy controllable conditions.

Description

technical field [0001] The invention relates to the technical field of starch materials, in particular to an injectable and self-healing starch-based hydrogel and its preparation method and application. Background technique [0002] All over the world, bone defects caused by trauma, tumor and infection are afflicting many patients every year. The current treatment for bone defects is bone grafting. Bone sources for bone grafting are usually divided into three categories: allogeneic bone, artificial bone substitute material (metal material) and autologous bone. Allogeneic bone and artificial bone materials have disadvantages such as mismatch of mechanical properties and rejection; for autologous bone, the source is limited and the bone part has health hazards. The limitations of various factors lead to the difficult development of traditional bone grafting. Hydrogel is a polymer three-dimensional network structure that absorbs and retains a large amount of water. It has si...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/16A61L27/20A61L27/02A61L27/50A61L27/52A61K9/06A61K47/32A61K47/36A61K47/02
CPCA61K9/0024A61K9/06A61K47/02A61K47/32A61K47/36A61L27/025A61L27/16A61L27/20A61L27/50A61L27/52A61L2400/06A61L2430/02C08L3/02C08L29/04
Inventor 汤晓智于晨孟令晗周剑敏
Owner 天津塑醒材料科技有限公司