Near-infrared quality detection system for ginkgo leaf purification process of Yinshen meridian-dredging capsule

Abstract

The invention discloses a near-infrared quality detection system for a ginkgo leaf purification process of a Yinshen capsule for dredging collaterals. Device comprising the following, the Fourier transform near-infrared spectrometer is used for collecting a near-infrared transmission spectrum of an eluent sample, taking air as a blank background, taking a quartz cuvette with the resolution of 8cm<-1 > and 2mm as a sample pool, scanning each sample spectrum for 32 times, collecting full-spectrum information, scanning each sample for three times, and obtaining an average spectrum through software processing; the high performance liquid chromatograph is used for carrying out chromatographic analysis on the reagent, and a chromatographic column is an XBridge Shield RP18 chromatographic column; wherein a mobile phase is a methanol-0. 4% phosphoric acid solution; the detection wavelength is 360 nm; wherein the flow rate is 1mL / min, and the sample size is 10mu L; the high-speed centrifuge isused for centrifuging the reagent to be centrifuged; and evaporating and concentrating the test solution by using a rotary evaporator. A ginkgo leaf macroporous resin purification process is taken asa research object, offline feasibility research before establishment of an online detection method is mainly carried out, and a research system is explored and preliminarily established.

Description

technical field [0001] The invention relates to the technical field of on-line monitoring of drug production, in particular to a near-infrared quality detection system for the purification process of ginkgo leaves of Yinshen Tongluo capsule. Background technique [0002] At present, there is a lack of unified and scientific quality control standards for most traditional Chinese medicine preparations. For example, in the whole process of traditional Chinese medicine extraction, separation, concentration, drying, preparation, and sterilization, each step of the pharmaceutical unit basically relies on manual control and offline testing. , the lack of objective process quality control and online detection and control of key quality control parameters, the low degree of production automation, resulting in difficult to overcome technical blind spots in internal quality control, making it difficult to achieve stable and uniform product quality between batches. Therefore, the researc...

AI Technical Summary

Problems solved by technology

[0002] At present, there is a lack of unified and scientific quality control standards for most traditional Chinese medicine preparations. For example, in the whole process of traditional Chinese medicine extraction, separation, concentration, drying, preparation, and sterilization, each step of the pharmaceutical unit basically relies on manual control and offline testing. , the lack of objective process quality control and online detection and control of key quality control parameters, the low degree of production automation, resulting in difficult to overcome technical blind spots in internal quality control, making it difficult to achieve stable and uniform product quality between batches. Therefore, the research The innovative application of fast and effective on-line inspection technology for the complex material and quality control system in the production process of traditional Chinese medicine tablets, the integrated application of key technologies for quality control in the production process, and the construction of a scientific and reliable quality control technology system for the whole process of Chinese medicine tablet production will provide a great guarantee for the quality of traditional Chinese medicine tablets. Provide technical support for the stability and controllability of medicines, ensure the safety and effectiveness of medicines, improve the technical level and technical content of the Chinese medicine industry as a whole, and promote the modernization process of Chinese medicines