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Temperature-sensitive hydrogel with visual diagnosis and treatment of infected wound and preparation method of hydrogel

A temperature-sensitive hydrogel and wound technology, applied in the field of materials, can solve the problem of inability to confirm whether the wound is infected, and achieve the effect of simple operation

Active Publication Date: 2020-04-28
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a temperature-sensitive hydrogel with visual diagnosis and treatment of infected wounds and its preparation method, which can effectively solve the problem that it is impossible to confirm whether the wound is infected in the current technology

Method used

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  • Temperature-sensitive hydrogel with visual diagnosis and treatment of infected wound and preparation method of hydrogel
  • Temperature-sensitive hydrogel with visual diagnosis and treatment of infected wound and preparation method of hydrogel
  • Temperature-sensitive hydrogel with visual diagnosis and treatment of infected wound and preparation method of hydrogel

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Embodiment 1

[0030] A method for preparing a temperature-sensitive hydrogel capable of visually diagnosing and treating infected wounds, characterized in that it comprises the following steps:

[0031] Step 1, get 37.5mL of bromothymol blue indicator that the mass volume concentration is 0.02%, join in hydrochloric acid, obtain hydrochloric acid final concentration and be 0.1mol / L and indicator mass volume ratio concentration be the mixed solution 50mL of 0.015% . The chitosan that 1.0g deacetylation degree is 90% joins above-mentioned mixed solution, stirs at room temperature, mixes and obtains mixed solution A, wherein the mass volume concentration of chitosan is 2%;

[0032] Step 2, 4.0g β-sodium glycerophosphate is dissolved with secondary water to obtain an aqueous solution of β-sodium glycerophosphate with a mass volume concentration of 33%. Take 13.89 μL, 27.78 μL and 41.67 μL of dimethyl sulfoxide solution (1.44 mg / mL) containing photothermal material, respectively, and add it to ...

Embodiment 2

[0036] A method for preparing a temperature-sensitive hydrogel capable of visually diagnosing and treating infected wounds, characterized in that it comprises the following steps:

[0037] Step 1, get 37.5mL of bromothymol blue indicator that the mass volume concentration is 0.02%, join in hydrochloric acid, obtain hydrochloric acid final concentration and be 0.1mol / L and indicator mass volume ratio concentration be the mixed solution 50mL of 0.015% . The chitosan that 1.0g deacetylation degree is 90% joins above-mentioned mixed solution, stirs at room temperature, mixes and obtains mixed solution A, wherein the mass volume concentration of chitosan is 2%;

[0038] Step 2, 4.0g β-sodium glycerophosphate is dissolved with secondary water to obtain an aqueous solution of β-sodium glycerophosphate with a mass volume concentration of 33%. Take 13.89 μL, 27.78 μL and 41.67 μL of dimethyl sulfoxide solution (1.44 mg / mL) containing photothermal material, respectively, and add it to ...

Embodiment 3

[0042] A method for preparing a temperature-sensitive hydrogel capable of visually diagnosing and treating infected wounds, characterized in that it comprises the following steps:

[0043] Step 1, get 37.5mL of bromothymol blue indicator that the mass volume concentration is 0.02%, join in hydrochloric acid, obtain hydrochloric acid final concentration and be 0.1mol / L and indicator mass volume ratio concentration be the mixed solution 50mL of 0.015% . The chitosan that 1.0g deacetylation degree is 90% joins above-mentioned mixed solution, stirs at room temperature, mixes and obtains mixed solution A, wherein the mass volume concentration of chitosan is 2%;

[0044] Step 2, 4.0g β-sodium glycerophosphate is dissolved with secondary water to obtain an aqueous solution of β-sodium glycerophosphate with a mass volume concentration of 33%. Take 13.89 μL, 27.78 μL and 41.67 μL of dimethyl sulfoxide solution (1.44 mg / mL) containing photothermal material, respectively, and add it to ...

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Abstract

The invention relates to the technical field of materials, and in particular relates to a temperature-sensitive hydrogel with visual diagnosis and treatment of an infected wound and a preparation method of the hydrogel. The preparation method comprises the following steps: firstly mixing chitosan and an acid containing an indicator to obtain a mixed solution A, secondly mixing beta-glycerophosphoric acid disodium salt and a solution containing a photothermal material to obtain a mixed solution B, and finally mixing the mixed solution A and the mixed solution B to obtain the indicator and photothermal material doped temperature-sensitive hydrogel. The temperature-sensitive hydrogel obtained by the method can detect whether the wound is infected in situ through naked-eye visible color change, the color of the hydrogel at the wound infection site changes from green to yellow, and after the wound is confirmed to be infected, heat generated by illumination is used to treat the infected site; the adopted preparation method is simple to operate, the hydrogel can be used for diagnosis without the aid of instrument; and the material has higher application value in antibacterial diagnosis and treatment.

Description

technical field [0001] The invention relates to the field of material technology, in particular to a temperature-sensitive hydrogel capable of visually diagnosing and treating infected wounds and a preparation method thereof. Background technique [0002] In recent years, about 17 million people die from bacterial infection every year in the world, and the cost caused by bacterial infection has become one of the important economic burdens in the world. After an injury, bacteria in the surrounding skin and environment will quickly accumulate at the wound site. When the number of bacteria does not stabilize at a certain level and exceeds the level of host immune clearance, the wound will fester and fester, making it difficult to heal, leading to clinically relevant infections. There is increasing evidence that the major lifestyle of bacteria within infected wounds is biofilm. Biofilm is a bacterial community attached to the extracellular matrix. The formation of biofilm is co...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/36A61K47/24A61K41/00A61P17/02A61P31/04A61K49/00
CPCA61K9/0019A61K9/06A61K41/0052A61K47/24A61K47/36A61K49/0073A61P17/02A61P31/04
Inventor 郭丽霞冯丽恒
Owner SHANXI UNIV
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