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Medical silk braided suture and preparation method thereof

A suture and silk technology, applied in the field of medical sutures, can solve the problems of no bacteriostatic effect, increase surgical site infection, etc., and achieve the effect of reducing infection, good mechanical properties and degradation properties, and promoting healing

Active Publication Date: 2022-07-05
深圳市迈捷生命科学有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as a non-absorbable suture, silk suture itself has no antibacterial effect on bacteria and viruses, and the gaps in the weaving structure and the single-fiber gaps inside the silk thread provide hiding places for bacteria, which increase the probability of surgical site infection

Method used

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  • Medical silk braided suture and preparation method thereof
  • Medical silk braided suture and preparation method thereof
  • Medical silk braided suture and preparation method thereof

Examples

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preparation example Construction

[0039] Preparation of p-nitrophenyl adipate: 110 g of p-nitrophenol, 71.88 g of triethylamine and 450 mL of acetone were sequentially added to the reaction device, and stirred and mixed at room temperature; A mixed solution of 60.405 g of adipoyl chloride and 150 mL of acetone was added to the dropping funnel, the dropping was completed within 1 hour, and the reaction was sufficient for 4 hours; after the reaction was sufficient, the reaction product was washed with water, and dried under vacuum at 55°C to constant weight to remove The moisture contained in the product yields p-nitrophenyl adipate.

[0040] Preparation of lysine dibutylene glycol ester: Weigh 85.12 g of L-lysine hydrochloride and 20 g of 1,4-butanediol and put them into the reaction device to mix, add 3 g of p-toluenesulfonic acid monohydrate and 25mL of toluene was stirred and reacted at 125°C for 2 hours; after the reaction was complete, the toluene was poured out, 500mL of isopropanol was added, and the mix...

Embodiment 1

[0047] In the preparation method of the medical silk woven suture, firstly, the lysine polyester hydrogel is loaded on the silk woven suture, and secondly, an antibacterial coating is prepared on the silk woven suture loaded with the lysine polyester hydrogel.

[0048] The process of loading lysine polyester hydrogel on silk braided sutures includes the following steps:

[0049] (1) Dissolve 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) in MES buffer with pH=5.5 and concentration of 0.05mol / L to obtain 1 -(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) solution with a concentration of 0.1 g / mL;

[0050] (2) Under ice bath conditions, immerse 3g of silk braided suture in 40mL of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) with a concentration of 0.1g / Activated by stirring for 24 hours in the solution of mL, as mixed solution I;

[0051] (3) Weigh the lysine polyester ammonia hydrogel and disperse it in water to prepar...

Embodiment 2

[0056] In the preparation method of the medical silk woven suture, firstly, the lysine polyester hydrogel is loaded on the silk woven suture, and secondly, an antibacterial coating is prepared on the silk woven suture loaded with the lysine polyester hydrogel.

[0057] The process of loading lysine polyester hydrogel on silk braided sutures includes the following steps:

[0058] (1) Dissolve 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) in MES buffer with pH=5.5 and concentration of 0.05mol / L to obtain 1 -(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) solution with a concentration of 0.1 g / mL;

[0059] (2) Under ice bath conditions, immerse 3g of silk braided suture in 40mL of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) with a concentration of 0.1g / Activated by stirring for 24 hours in the solution of mL, as mixed solution I;

[0060] (3) Weigh the lysine polyester ammonia hydrogel and disperse it in water to prepar...

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Abstract

The invention discloses a medical silk braided suture and a preparation method thereof. First, lysine polyester hydrogel is loaded on the silk braided suture, and then antibacterial is prepared on the silk braided suture loaded with the lysine polyester hydrogel. coating. The medical silk braided suture of the present invention has good mechanical properties and degradability, has antibacterial properties and achieves a stable and lasting effect of antibacterial properties, can effectively promote wound healing, and reduce surgical site infection.

Description

technical field [0001] The invention relates to the technical field of medical sutures, in particular to a medical silk braided suture and a preparation method thereof. Background technique [0002] As a natural protein fiber containing 18 kinds of amino acids, silk can produce many amino acids needed by the human body under the decomposition of enzymes and microorganisms after being sewn into the human body, which is absorbed by the human body, not only harmless to the human body, but also provides useful. nourishment. Compared with the chemical fiber medical sutures of the same thread size, the silk sutures are also excellent in terms of flexibility, knotting and bending, etc. At the same time, the silk sutures have good hygroscopicity and can rapidly expand when infiltrated by blood. Needle eye, reduce blood leakage from the needle hole, and the operation quality is good; the strength of silk suture is also better than that of general natural material suture, such as cot...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L17/10A61L17/14A61L17/00D06M15/507D06M13/152
CPCA61L17/105A61L17/145A61L17/005D06M15/507D06M13/152D06M16/00A61L2300/404A61L2420/02A61L2420/08A61L2300/412A61L2300/602A61L2300/608D06M2101/10C08L67/00
Inventor 刘科林
Owner 深圳市迈捷生命科学有限公司
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