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Novel application of compound in treatment of pharyngitis

A compound, pharyngitis technology, applied in the field of medicine, can solve problems such as large toxic side effects, great harm, complications and so on

Pending Publication Date: 2020-05-12
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Acute pharyngitis is a common and frequently-occurring disease in otolaryngology. Severe cases can cause many complications and cause great harm. Western medicine mainly treats this disease with antibiotics, but it has the disadvantages of large toxic side effects, double infection, and easy drug resistance.

Method used

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  • Novel application of compound in treatment of pharyngitis
  • Novel application of compound in treatment of pharyngitis
  • Novel application of compound in treatment of pharyngitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1. The compound of the present invention treats the effect of acute pharyngitis

[0024] The compound used in this example is the compound prepared in Example 2.

[0025] 1.1 Preparation of acute pharyngitis model

[0026] With reference to the rat acute pharyngitis model method established in "Research on Animal Models of Acute Pharyngitis", Chinese Journal of Experimental Formulas, 2001, 7(3):52-54, the animal model of acute pharyngitis was formed by spraying ammonia water in the pharynx.

[0027] 1.2 Experimental grouping

[0028] Experimental rats are divided into normal group, model group, aspirin control group (dose is 200mg / kg) and compound group (dose is 50mg / kg), every group 10, normal group does not do treatment, model group, aspirin control group and the compound group all sprayed 25% concentrated ammonia water to the throat of rats with a throat sprayer, twice a day, once in the morning and afternoon, and sprayed 3 times each time. After 3 days of continuo...

Embodiment 2

[0055] The preparation of embodiment 2 formula 1 compound

[0056] Take 100g of crushed lotus seed heart medicinal material, add 2L of 55% ethanol, heat and reflux for 20 minutes, separate the residue and extract; add 1L of 55% ethanol to the residue and reflux twice, each time for 10 minutes, separate the residue and extract ; Combine the extracts obtained by refluxing the above 3 times, and recycle the ethanol by distillation under reduced pressure to obtain the crude extract of the lotus seed heart. Suspend the crude extract extract in water, put it on HPD300 macroporous adsorption resin column, elute with 30% ethanol of 5 times column volume, and discard the eluent. Then elute with 80% ethanol, collect the eluate, and distill under reduced pressure to recover the solvent to obtain the extract of the lotus seed heart. Diethyl ether-phosphate buffer was used as a high-speed countercurrent chromatography two-phase solvent system to separate and purify the lotus seed heart ex...

Embodiment 3

[0064] Take 10 g of the compound of formula 1, add appropriate auxiliary materials for injections (including freeze-dried powder injections and sterile subpackaged dry powder injections), and prepare injections according to the injection (including freeze-dried powder injections and sterile subpackaged dry powder injections) process.

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Abstract

The invention provides application of a compound of a structure shown in a formula 1 as shown in the description in production of a medicine for treating pharyngitis. According to application of the compound of the structure shown in the formula 1 as shown in the description in production of the medicine for treating pharyngitis, studies show that the compound has significant improving effects onpharyngitis, especially acute pharyngitis.

Description

technical field [0001] The application relates to a new use of a compound, in particular to a new use of the compound for treating pharyngitis, and belongs to the field of medicine. Background technique [0002] Pharyngitis (pharyngitis) is non-specific inflammation of the pharynx. It is a general term for inflammation caused by various microorganisms infecting the pharynx. It can exist alone or coexist with rhinitis, tonsillitis and laryngitis, or it can be the prodromal symptom of certain diseases. Can be divided into acute pharyngitis and chronic pharyngitis. [0003] Acute pharyngitis belongs to the category of "acute sore throat" in traditional Chinese medicine. Clinically, it is characterized by sore throat, aggravated when swallowing, acute hyperemia and swelling of the pharyngeal mucosa, red and swollen lymphatic follicles on the posterior pharyngeal wall and pharyngeal lateral cord, swelling and tenderness of submandibular lymph nodes, and symptoms of wind-heat in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4725A61P11/04
CPCA61K31/4725A61P11/04
Inventor 李韶菁陈修平吴传鸿
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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