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Artificial bionic intestinal canal and manufacturing method thereof

A manufacturing method and intestinal technology, applied in the field of bionics, can solve the problems of reducing the degree of simulation of the bionic intestinal system, difficulty in controlling the uniformity of application, etc., and achieve the effects of improving bonding fastness, good elasticity, and increasing service life

Inactive Publication Date: 2020-05-12
中国人民解放军西部战区总医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the bionic duodenum does not have the function of the duodenum to absorb nutrients after digesting food, resulting in the accumulation of intermediates and products in the reactor, which inhibits digestive enzymes and reduces the efficiency of the entire bionic intestinal system. The degree of simulation; and this bionic duodenum is obtained by smearing a certain thickness of silicone on the surface of the mold for curing, and the uniformity of smearing is difficult to control

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036]An artificial bionic intestinal tract, the artificial bionic intestinal tract comprises a porous silicone rubber substrate with a pore diameter of 100 μm and a porous separation membrane with a pore diameter of 50 nm from the outside to the inside; the thickness of the porous separation membrane is 50 μm; the porous silicone rubber The inner wall of the base contains evenly distributed fine protrusions with a diameter of 0.5 mm and a height of 1 mm. Prepared by:

[0037] S1. According to the accurate anatomical model of the human intestine in the Department of Gastroenterology, a tubular human intestinal mold is made. The mold consists of a mandrel and a sleeve to form an inner cavity, and the thickness of the inner cavity is 3mm; the surface of the mandrel contains uniformly distributed small protrusions, the diameter of the protrusions is 0.5 mm, the height is 1 mm, and the distance between each protrusion is 0.5 mm;

[0038] S2. Weigh 100 parts of vinyl silicone oil,...

Embodiment 2

[0046] An artificial bionic intestinal tract, the artificial bionic intestinal tract comprises a porous silicone rubber substrate with a pore diameter of 300 μm and a porous separation membrane with a pore diameter of 200 nm from the outside to the inside; the thickness of the porous separation membrane is 100 μm; the porous silicone rubber The inner wall of the base contains evenly distributed fine protrusions with a diameter of 0.5 mm and a height of 1 mm. Prepared by:

[0047] S1. According to the accurate anatomical model of the human intestine in the Department of Gastroenterology, a tubular human intestinal mold is made. The mold consists of a mandrel and a sleeve to form an inner cavity, and the thickness of the inner cavity is 3mm; the surface of the mandrel contains uniformly distributed small protrusions, the diameter of the protrusions is 0.5 mm, the height is 1 mm, and the distance between each protrusion is 0.5 mm;

[0048] S2. Weigh 100 parts of vinyl silicone o...

Embodiment 3

[0056] An artificial bionic intestinal tract, the artificial bionic intestinal tract comprises a porous silicon rubber substrate with a pore size of 1 μm and a porous separation membrane with a pore size of 500 nm from the outside to the inside; the thickness of the porous separation membrane is 200 μm; the porous silicone rubber The inner wall of the base contains evenly distributed fine protrusions with a diameter of 1 mm and a height of 2 mm. Prepared by:

[0057] S1. According to the accurate anatomical model of the human intestine in the Department of Gastroenterology, a tubular human intestinal mold is made. The mold consists of a mandrel and a sleeve to form an inner cavity, and the thickness of the inner cavity is 3mm; the surface of the mandrel contains uniformly distributed small protrusions, the diameter of the protrusions is 1 mm, the height is 2 mm, and the distance between each protrusion is 1 mm;

[0058] S2. Weigh 100 parts of vinyl silicone oil, 3 parts of hy...

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Abstract

The invention provides an artificial bionic intestinal canal and a manufacturing method thereof. The artificial bionic intestinal canal comprises a porous silicon rubber base and a porous separating membrane; the inner wall of the porous silicon rubber base comprises small bumps which are distributed uniformly so that the specific surface area of the inner wall is increased; and the porous separating membrane is used for separating small-molecular nutrient substances. The manufacturing method of the artificial bionic intestinal canal comprises the following steps of: firstly, manufacturing a tubular mold; filling the tubular mold with a silica gel raw material; curing and afterwards carrying out perforation to obtain the porous silicon rubber base; and etching the inner wall of the poroussilicon rubber base and then manufacturing a layer of polyether block silicon oil porous separating membrane to obtain the artificial bionic intestinal canal. A mandrel of the mold comprises small bumps which are distributed uniformly so that small bumps are formed on the inner wall of the bionic intestinal canal; the surface of the silicon rubber base is perforated so that small-molecular nutrient substances can be separated via the separating membrane; the inner wall of the silicon rubber base is etched to improve the reaction activity of the silicon rubber base; and thus the bonding strength of the porous separating membrane and the silicon rubber base is improved.

Description

technical field [0001] The invention belongs to the field of bionic technology and the field of biotechnology, and relates to an artificial bionic intestinal tract and a manufacturing method thereof. Background technique [0002] In the research process of food and medicine, it is very important to objectively and accurately evaluate the digestion process of food and medicine in the human body to determine the components of food and medicine and their effects on the human digestive tract. [0003] The in vitro bionic digestive system of the human digestive tract (such as SHIME, IViDiS, TIM, DGM, HGS, etc.) is a bionic simulation of the human digestive system, its digestive environment, and the fluid dynamic behavior in the digestive tract, which can simulate the behavior of different samples in an in vitro model. The digestion process and the impact of these samples on intestinal microorganisms provide a large amount of valuable data for the development of new functional foo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C69/00G09B23/28
CPCB29C69/00G09B23/28
Inventor 郝彬
Owner 中国人民解放军西部战区总医院
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