Application of abrus cantoniensis hance extract in preparation of anti-cancer drug

An anticancer drug, the technology of chicken bone grass, applied in the field of medicine, can solve the problems of tumor cell apoptosis, achieve the effect of reducing liver index and increasing tumor inhibition rate

Inactive Publication Date: 2020-05-15
右江民族医学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no report about the apoptosis of tumor cells by promoting bax protein and inhibiting the expression of bcl-2.

Method used

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  • Application of abrus cantoniensis hance extract in preparation of anti-cancer drug
  • Application of abrus cantoniensis hance extract in preparation of anti-cancer drug
  • Application of abrus cantoniensis hance extract in preparation of anti-cancer drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 The preparation of the extract of A. japonicus and the study of its anti-tumor activity in vivo.

[0034] 1 Materials and methods

[0035] 1.1 Materials

[0036] 1.1.1 The medicinal material Jigucao was purchased from Baise City, Guangxi (it was identified as the whole herb of Acacia guangdongensis by Associate Professor Qin Daoguang of the Ethnic Medicine Teaching and Research Office of Youjiang Medical College for Nationalities).

[0037] 1.1.2 Cells and experimental animal cell lines Human gastric cancer cell line SGC-7901, human liver cancer cell line BEL-7404 and human breast cancer cell line MCF-7 were purchased from the Kunming Cell Bank of the Chinese Academy of Sciences. The cells were cultured in DMEM medium containing 10% fetal bovine serum in an incubator with a temperature of 37°C, saturated humidity, and 5% CO2. 4-5 weeks old SPF grade BALB / c nude mice were purchased from Tianqin Company in Changsha, Hunan. Certificate number: NO.20181012, kep...

Embodiment 2

[0072] Example 2 The preparation and in vitro anti-tumor activity of the extract of Chickweed

[0073] 2.1 Materials and Instruments

[0074]Chicken bone grass was purchased from Baise City, Guangxi (identified by Associate Professor Qin Daoguang from the Ethnic Medicine Teaching and Research Office of Youjiang National Medical College as the whole herb of Acacia guangdongensis in the leguminous family); the cell line used was human gastric cancer cell line SGC-7901, human liver cancer Cell line BEL-7404 and human breast cancer cell line MCF-7 were purchased from the Kunming Cell Bank of the Chinese Academy of Sciences; RPMI-1640 medium, DMEM high-glucose medium: Thermo Fisher Scientific; premium fetal bovine serum: AusGeneX; sterile PBS, CCK-8 reagent: Boster; dimethyl sulfoxide (DMSO): Sigma Company; 0.25% EDTA-pancreatin: Beijing Suolaibao Company; Hoeshst33258 staining solution: KGI; PI staining reagent Box: Sangon Bio (Shanghai) Co., Ltd. ethanol, petroleum ether, ethyl ...

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Abstract

The invention belongs to the field of medicines, and particularly relates to application of an abrus cantoniensis hance extract in preparation of an anti-cancer drug. The abrus cantoniensis hance extract is an abrus cantoniensis hance petroleum ether extract, an abrus cantoniensis hance ethyl acetate extract, an abrus cantoniensis hance n-butanol extract and/or an abrus cantoniensis hance water extract. The abrus cantoniensis hance extract provided by the invention can promote expression of bax protein and inhibit bcl-2 to cause apoptosis of tumor cells, and has important significance in preparation of the anti-cancer drug, especially drugs for treating gastric cancer, liver cancer and breast cancer.

Description

【Technical field】 [0001] The invention relates to the field of medicine, in particular to the application of the extract of Chickenia japonicus in the preparation of anticancer drugs. 【Background technique】 [0002] Cancer is the second biggest killer of human health. At present, drug resistance often occurs during the clinical use of chemotherapy drugs. Cancer cells are often not killed, and tumors often recur and metastasize, leading to death. One of the most important reasons is that the apoptosis suppressor gene (Bcl2 gene) in these cancer cells is highly expressed, which makes the tumor cells resist apoptosis and not die, so that tumor recurrence and metastasis often occur. Therefore, inhibiting the expression of tumor Bcl2 gene is one of the important ways to improve drug efficacy, completely kill cancer cells and prevent tumor recurrence and metastasis. [0003] There are a wide range of biologically active substances in the natural products of Chinese herbal medicin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P35/00
CPCA61K36/48A61K2236/331A61K2236/333A61K2236/35A61P35/00
Inventor 黄锁义李庭树莫仁高陈小妮雷智冬陈石梅王金妮
Owner 右江民族医学院
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