Preparation of matrine oxide
A technology for oxymatrine and preparation process, applied in the direction of organic chemistry and the like, can solve the problems of low yield, difficulty in large-scale industrial production, and high cost, and achieve the effects of simple preparation process, high product purity, and easy realization.
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Embodiment 1
[0044] Add 20 g of matrine into 15 g of hydrogen peroxide, react at 70° C. for 14 hours, and extract unreacted matrine with ether until there is basically no matrine in the reaction solution. Concentrate the reaction solution under reduced pressure, extract the concentrated solution under reduced pressure with chloroform, concentrate the extract under reduced pressure to obtain extract, dissolve and filter with ethanol, concentrate the filtrate under reduced pressure, add acetone to the concentrated solution to reflux, cool, precipitate crystals, and filter with suction , 15.5 g of crystals were obtained, which was oxymatrine.
Embodiment 2
[0046] 20 g of matrine was added to 15 g of hydrogen peroxide, stirred and reacted at 60° C. for 14 hours, and unreacted matrine was extracted with cyclohexane until there was basically no matrine in the reaction solution. After the reaction solution was concentrated under reduced pressure, it was extracted with chloroform, anhydrous sodium sulfate was added to the extract and dried and filtered, anhydrous ether was added to the filtrate, and 13 g of crystals were precipitated, which was oxymatrine.
Embodiment 3
[0048] 100 g of matrine was added to 75 g of hydrogen peroxide, stirred and reacted at 40° C. for 18 hours, and unreacted matrine was extracted with benzene until there was basically no matrine in the reaction solution. The reaction solution was concentrated under reduced pressure, extracted with chloroform, anhydrous ether was gradually added to the chloroform solution, and 90 g of a white solid was precipitated, which was oxymatrine.
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