A long-lasting anti-influenza medical mask
An anti-influenza and mask technology, applied in the field of long-term anti-influenza medical masks, can solve the problem of not killing viruses, and achieve the effects of inhibiting survival and transmission, promoting internal and external circulation, and reducing the feeling of suffocation.
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Embodiment 1
[0017] The synthesis of embodiment 1 polypeptide
[0018] The 9-fluorenylmethoxycarbonyl (Fmoc) synthesis strategy was used to synthesize from the C-terminal to the N-terminal. 10mg of Rink-Amide-Resin resin (AAPPTec, product number RRZ001) was used as a carrier, and the active group of the carrier itself was connected to the carboxyl group of 5mg of the first amino acid (Fmoc-Q-NH2) protected by Fmoc.
[0019] Rinse the resin with N-methylpyrrolephrine (NMP) to remove redundant protected amino acids, add 20% piperidine / NMP solution (volume fraction) to the reactor (solid phase synthesizer) to remove the Fmoc group, react for 20min, Empty the reactor, wash the resin with 5mL NMP shaking, repeat 3 times, remove the Fmoc protection of the first amino acid residue; the exposed active amino group is connected to the carboxyl group of the next amino acid (5mg) that is amino-protected by Fmoc , forming the first peptide bond (Q-H). The above steps in this section are repeated (the...
Embodiment 2
[0020] Example 2 protein binding experiment
[0021] A / Brisbane / 10 / 2007(H3) HA protein, A / California / 04 / 2009(H1N1) HA protein, A / Canada / 720 / 2005(H2N2) HA protein, A / Anhui / 1 / 2005(H5N1) ) HA protein, A / Netherlands / 219 / 03 (H7N7) HA protein mixed with coating solution (synthetic peptide with a final concentration of 100ng / mL) coated in 96-well plate, overnight at 4°C, 1% BSA / PBS at 37 ℃ block 1h. Washed with PBST for 3 times, the serum after the first immunization was used as the primary antibody, diluted in PBST, the first dilution was 1:200, 5-fold serial dilution, and incubated at 37°C for 1.5h. Wash 3 times with PBST, the secondary antibody is HRP-labeled mouse secondary antibody, diluted in PBST, the dilution ratio is 1:3000, incubate at 37°C for 45min, wash 3 times with PBST, add TMB substrate for color development, at OD 450 UV light was detected at the place where human serum albumin was used as a control. The results are shown in Table 1 below.
[0022] Table 1 The bi...
Embodiment 3
[0024] The preparation of embodiment 3 masks
[0025]The preparation of nanofiber layer: add 1 part (parts by weight) polyamine and guanidinium salt polymer in the raw material of making gauze, 4 parts (parts by weight) polypropylene special material, 95 parts (parts by weight) polypropylene vinyl resin , mixed at 500°C for 45 minutes and granulated to form an antiviral matrix resin. The resin was processed into nanofibers with a diameter of 50nm and then processed into a sheet, and immersed in a concentration of 330ppm or 350ppm of nano-silver nitrate for 1h, followed by drying, then immersing in the antiviral polypeptide solution prepared in Example 1 for 30min at 45 degrees Celsius, and drying;
[0026] Preparation of the mask: Take the non-woven fabric sheet and laminate it on both sides of the nanofiber layer prepared above, and then press and form it at high temperature after 2 repeated superimpositions. The non-woven fabric sheet is provided with regularly formed throug...
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