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A kind of PVA-based liquid dressing and preparation method thereof

A liquid dressing and solution technology, applied in the medical field, can solve the problems of high price, slow sterilization speed, weak antibacterial ability, etc., and achieve the effects of convenient use, reduced time required, and soft feel

Active Publication Date: 2020-12-29
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on antibacterial agents at home and abroad mainly includes organic antibacterial agents, inorganic antibacterial agents, natural antibacterial agents and polymer antibacterial agents, etc., but these antibacterial agents have certain shortcomings, such as weak antibacterial ability, slow sterilization speed, high price, etc.

Method used

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  • A kind of PVA-based liquid dressing and preparation method thereof
  • A kind of PVA-based liquid dressing and preparation method thereof
  • A kind of PVA-based liquid dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] A preparation method of a liquid dressing, comprising the following steps:

[0075] (1) Prepare a PVA solution with a mass fraction of 8% (the mass ratio of PVA to water is 8:92), heat it in an oil bath at 90°C until it is completely dissolved; cool down to 70°C, and then add EVC (PVA and EVC The molar ratio is 2:1), stirred (stirring speed is 1000rpm) reaction 5h, obtains PVA / EVC mixed solution;

[0076] (2) Add xanthan gum (0.5% of the quality of the PVA / EVC mixed solution), glycerin (5% of the quality of the PVA / EVC mixed solution) to the PVA / EVC mixed solution of step (1), and continue to stir for 12h A mixed solution is obtained, marked as PVA / EVC;

[0077] (3) the antibacterial agent MC / ethanol solution that adds in the mixed solution of step (2), wherein, the mass ratio of antibacterial agent MC / ethanol solution and the mixed solution of step (2) is 25:100, antibacterial agent MC / ethanol The mass ratio of the antibacterial agent MC to ethanol in the solution is...

Embodiment 2

[0086] A preparation method of a liquid dressing, comprising the following steps:

[0087] (1) Prepare a PVA solution with a mass fraction of 10% (the mass ratio of PVA to water is 10:90), heat it in an oil bath at 90°C until it is completely dissolved; cool down to 70°C, and then add EVC (PVA and EVC The molar ratio is 1:1), stirred (stirring speed is 1000rpm) reaction 12h, obtains PVA / EVC mixed solution;

[0088] (2) Add xanthan gum (0.5% for the quality of the PVA / EVC mixed solution), glycerin (2% for the quality of the PVA / EVC mixed solution) in the PVA / EVC mixed solution of step (1), continue to stir for 12h Obtain a mixed solution, marked as PVA / EVC;

[0089] (3) the antibacterial agent MC / ethanol solution that adds in the mixed solution of step (2), wherein, the mass ratio of antibacterial agent MC / ethanol solution and the mixed solution of step (2) is 25:100, antibacterial agent MC / ethanol The mass ratio of the antibacterial agent MC to ethanol in the solution is 0.7...

Embodiment 3

[0098] The mass fraction of the PVA solution in Example 1 was adjusted to 6%, 10%, and 12%, and other parameters remained unchanged, and performance tests were performed.

[0099] The test results show that: when the PVA mass fraction is low, the solution prepared by the method of Example 1 is dilute, the film-forming property is poor, and the required film-forming time is long; when the PVA mass fraction is high, the obtained liquid after adding xanthan gum The dressing is too thick and inconvenient to use.

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Abstract

The invention discloses a liquid dressing based on polyvinyl alcohol (PVA) and a preparation method of the liquid dressing, and belongs to the technical field of medical treatment. The preparation method of the liquid dressing comprises the following steps: (1) adding 1,2-epoxy-4-vinylcyclohexane (EVC) into a polyvinyl alcohol (PVA) solution, and performing uniform stirring to obtain a PVA / EVC mixed solution, wherein the molar ratio of the PVA to the EVC is (1-3):(1-3); (2) adding xanthan gum and glycerol into the PVA / EVC mixed solution obtained in the step (1), and continuing uniform stirringto obtain a mixed solution; and (3) adding an antibacterial agent / ethanol solution into the mixed solution obtained in the step (2), performing full stirring, and performing defoaming to obtain the liquid dressing. The liquid dressing prepared by the method has flexible hand feeling, transparent appearance, water vapor permeability and good antibacterial performance, and can be completely torn off without residues after being dried to form a film.

Description

technical field [0001] The invention relates to a PVA-based liquid dressing and a preparation method thereof, belonging to the field of medical technology. Background technique [0002] Bacteria, fungi and microorganisms widely exist in our daily life environment. If the human skin is scratched or damaged and cannot be treated in a timely and effective manner, the wound healing will be delayed, the wound will be easily infected, and even cause serious complications. Therefore, research on wound dressings is particularly important. [0003] At present, traditional dressings such as absorbent cotton and gauze, which are widely used clinically, have too strong liquid absorption capacity, which is not conducive to cell survival and tissue regeneration. The granulation tissue formed during wound healing is prone to adhesion with the dressing. Deals secondary damage when removed. In addition, they need to be fixed with medical tape during use, which is relatively limited in the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00
CPCA61L26/0014A61L26/0023A61L26/0061A61L26/0066A61L2300/204A61L2300/404C08L5/00C08L29/04
Inventor 刘颖郑玉霞任学宏
Owner JIANGNAN UNIV