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Qualitative detection method for pioglitazone and rosiglitazone in food and medicine

A qualitative detection, pioglitazone technology, applied in the preparation of test samples, measuring devices, instruments, etc., can solve the problem of low accuracy of test results

Pending Publication Date: 2020-05-29
SHANXI PROVINCE FOOD & DRUG INSPECTION INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, surface-enhanced Raman spectroscopy is used to detect pioglitazone and rosiglitazone using acid for extraction, which has the problem of low accuracy of detection results

Method used

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  • Qualitative detection method for pioglitazone and rosiglitazone in food and medicine
  • Qualitative detection method for pioglitazone and rosiglitazone in food and medicine
  • Qualitative detection method for pioglitazone and rosiglitazone in food and medicine

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Experimental program
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Embodiment 1

[0048] 1.1 Materials and reagents

[0049] Gold Nanoparticles 202 (OTR202) Optus (Suzhou) Optical Nano Technology Co., Ltd.

[0050] Gold Nanoparticles 103 (OTR103) Optus (Suzhou) Optical Nano Technology Co., Ltd.

[0051] Chloroform Sinopharm Chemical Reagent Co., Ltd.

[0052] Deionized water

[0053] Methanol Sinopharm Chemical Reagent Co., Ltd.

[0054] Pioglitazone, Rosiglitazone 100634-201202 China National Institutes for Food and Drug Control

[0055] XXX Soft Capsule Beijing XXX Pharmaceutical Technology Co., Ltd.

[0056] XXX Hard Capsule Zhongshan XXX Biopharmaceutical Co., Ltd.

[0057] XXX Tea Beijing XXX Traditional Chinese Medicine Co., Ltd.

[0058] XXX capsule positive sample

[0059] 1.2 Experimental Instruments

[0060] Opto Trace-200 Laser Raman Spectrometer Optous (Suzhou) Optical Nano Technology Co., Ltd.

[0061] Micro Centrifuge Optus (Suzhou) Optical Nano Technology Co., Ltd.

[0062] 3K15 refrigerated centrifuge SIGMA Xima centrifuge

[0063] ...

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Abstract

The invention provides a qualitative detection method for pioglitazone and rosiglitazone in foods and medicines and belongs to the field of substance detection. The method is characterized in that twotypes of gold nanoparticles are proportioned to serve as nanoparticle enhancing reagent, water-saturated trichloromethane serves as extracting agent for extraction, acid is not needed for extraction,the method is safer, interference is reduced, the Raman effect of a target object is enhanced, the characteristics are more obvious and the strength is higher under the same concentration, and then accuracy of the detection result can be improved. Data of the embodiment show that the method is suitable for detecting the illegally added pioglitazone and the rosiglitazone in the hypoglycemic health-care food by surface enhanced Raman spectroscopy, and detection limits of the method are both 15 mu g / mL.

Description

technical field [0001] The invention relates to the technical field of substance detection, in particular to a qualitative detection method for pioglitazone and rosiglitazone in food and medicine. Background technique [0002] In modern society, people's quality of life is constantly improving, and the population of patients with hyperglycemia is getting younger and larger. How to treat hyperglycemia has become the focus of attention. However, drug treatment of hyperglycemia will bring a lot of psychological burden to patients, so health food has become the first choice for people. However, health food takes a long time to take effect, and it is not easy to see the effect in a short period of time. Many unscrupulous businesses have seized this psychology of patients and illegally added chemical drugs to health food to make the effect of health food more significant. Among them, the commonly used hypoglycemic drugs include metformin, glibenclamide, pioglitazone, etc. These d...

Claims

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Application Information

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IPC IPC(8): G01N21/65G01N1/28
CPCG01N21/658G01N1/28G01N1/286G01N2001/2866
Inventor 董培智杨国伟申国华王培宇梁卜文王珂张禄刘晓普
Owner SHANXI PROVINCE FOOD & DRUG INSPECTION INST
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