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Method for extracting atractylodes lancea ketone by using ultrahigh pressure technology

An ultra-high pressure technology, atractylodes ketone technology, applied in organic chemistry and other directions, can solve the problems of degradation of atractylodes ketone biological activity destruction, low yield, high energy consumption, and achieve strong anti-pollution ability, stable physical and chemical properties, and fast exchange speed. Effect

Inactive Publication Date: 2020-06-02
南京西博恩生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Therefore, the present invention proposes an extraction process of atractylone, which is used to solve the long time-consuming, high energy consumption, low yield, high temperature degradation of atractylone and the biological activity of atractylone brought about by traditional hot water extraction. sabotage problem

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A method for extracting atractylone in Atractylodes atractylodes by ultra-high pressure technology, the steps are as follows:

[0020] (1) Put the rhizome of Atractylodes atractylodis under vacuum for 24 hours at 50°C;

[0021] (2) The dried Atractylodes atractylodis is crushed with a granulator under normal temperature conditions;

[0022] (3) After passing through a 60-mesh sieve, the pulverized Atractylodes atractylodes is put into a pressure-resistant bag, and 10 times the volume of ethanol with a concentration of 70% is added, and treated at an ultra-high pressure of 200MPA, 10min, and 18°C, and the ethanol is recovered. Vacuum dried at 60°C to obtain the crude product;

[0023] (4) Add an appropriate amount of 75% ethanol to dissolve the obtained crude atractylone powder, adjust its pH value to 5.5, heat to 60°C, add 2.0% pectinase (1 million u / ml), mix well and keep enzymatic hydrolysis for 0.5h . Cool to room temperature, let stand, filter, discard the filter...

Embodiment example 2

[0030] A method for extracting atractylone in Atractylodes atractylodes by ultra-high pressure technology, the steps are as follows:

[0031] (1) Put the rhizome of Atractylodes atractylodis under vacuum for 24 hours at 50°C;

[0032] (2) The dried Atractylodes atractylodis is crushed with a granulator under normal temperature conditions;

[0033] (3) Put the pulverized Atractylodes atractylodes into a pressure-resistant bag after passing through an 80-mesh sieve, add 12 times the volume of ethanol with a concentration of 90%, and process it at an ultra-high pressure of 300MPA, 15min, and 20°C, and reclaim the ethanol. Vacuum dried at 60°C to obtain the crude product;

[0034] (4) Add an appropriate amount of 75% ethanol to dissolve the obtained crude atractylone powder, adjust its pH value to 7.5, heat to 60°C, add 2.0% pectinase (1 million u / ml), mix well and keep enzymatic hydrolysis for 1.5h . Cool to room temperature, let stand, filter, discard the filter residue, and ...

Embodiment example 3

[0041] A method for extracting atractylone in Atractylodes atractylodes by ultra-high pressure technology, the steps are as follows:

[0042] (1) Put the rhizome of Atractylodes atractylodis under vacuum for 24 hours at 50°C;

[0043] (2) The dried Atractylodes atractylodis is crushed with a granulator under normal temperature conditions;

[0044] (3) Put the pulverized Atractylodes atractylodis through an 80-mesh sieve, put it into a pressure-resistant bag, add 12 times the volume of ethanol with a concentration of 80%, and process it at an ultra-high pressure of 200MPA, 12min, and 18°C, and reclaim the ethanol. Vacuum dried at 60°C to obtain the crude product;

[0045] (4) Add an appropriate amount of 75% ethanol to dissolve the obtained crude atractylone powder, adjust its pH value to 4.5, heat to 50°C, add 1.5% pectinase (1 million u / ml), mix well and keep enzymatic hydrolysis for 2 hours. Cool to room temperature, let stand, filter, discard the filter residue, and conce...

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Abstract

The invention relates to an extraction method of atractylodes lancea ketone. According to the invention, an ultrahigh pressure technology is a treatment method for applying pressure of more than 100 MPa to raw materials under the conditions of normal temperature and near normal temperature, a solvent can enter plant cells under ultrahigh pressure, after pressure relief, the solvent can overflow along with effective components to achieve the high extraction efficiency of the effective components of the plants, and a macroporous resin is used for adsorbing and purifying atractylodes lancea ketone, wherein the adsorption selectivity on the atractylodes lancea ketone is good, the adsorption speed is high, the desorption speed is high, the adsorption capacity is large, and the defects of low extraction rate, low extraction purity and the like in the conventional technology are overcome.

Description

technical field [0001] The invention belongs to the field of natural organic chemistry, and relates to a method for purifying atractylone, in particular to a method for extracting atractylone from atractylodes atractylodes by ultra-high pressure technology. Background technique [0002] Atractylodes atractylodes is not only a traditional precious Chinese medicinal material in my country but also a common food ingredient in the folk. It has various pharmacological effects and biologically active functions. According to modern medical clinical research, Atractylodes ketone extracted from Atractylodes atractylodes is one of the main active ingredients in the biological function of Atractylodes atractylodes, and it has become an important functional additive of health food. In recent years, domestic research on ketones has progressed rapidly, and the extraction and separation, chemical analysis, pharmacological effects and clinical application of atractylone have a relatively ex...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/92
CPCC07D307/92
Inventor 董妍
Owner 南京西博恩生物科技有限公司
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