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A composition comprising rapamycin and its use

A technology of rapamycin and composition, which is applied in the field of composition containing rapamycin, can solve the problem that the effect of skin repair and anti-aging can not achieve satisfactory effect, so as to shorten the onset time and improve skin quality. Restorative and anti-aging effects

Active Publication Date: 2021-06-29
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, the skin repair and anti-aging effects of the existing polysaccharide hydrophilic hydrogel products cannot achieve satisfactory results.

Method used

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  • A composition comprising rapamycin and its use
  • A composition comprising rapamycin and its use
  • A composition comprising rapamycin and its use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Hyaluronic acid gel and chitosan gel were prepared respectively, and rapamycin was uniformly distributed in hyaluronic acid gel and chitosan gel by means of ultrasonic vibration, and the concentration of rapamycin was 10 μM, and the obtained Rapamycin-hyaluronic acid composition (referred to as LT) and rapamycin-chitosan composition (referred to as LK).

Embodiment 2

[0043]Modeling and intervention: 40 6-week-old SPF-grade male nude mice were randomly divided into 5 groups: normal group (NC), model group (Model), LT group, LK group, LY (Ray Pamycin saline solution, the concentration of rapamycin is 10 μM) group, 10 rats in each group. Except for the normal group, the animals in other groups were subcutaneously injected with D-gal (1000 mg / kg, subcutaneously) on the back every day for 8 weeks, and the left and right sides of the back were compared. All animals were allowed free access to water and food, and were observed daily for changes in the skin at the injection site on the back. Take pictures and record. From the 8th week, rapamycin-hyaluronic acid, rapamycin-chitosan and rapamycin liquid were applied to the LT group, LK group and LY group respectively once a day for 4 weeks. brine. The mice were sacrificed at the 12th week, and a small piece of skin in the same area of ​​the back was taken for histological examination, stained wit...

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Abstract

The invention relates to the field of medicine, and discloses a composition containing rapamycin and its application. The composition of the present invention comprises rapamycin and a hydrogel material, wherein the rapamycin is evenly distributed in the gel material, and the gel material is hyaluronic acid gel or / and chitosan gel. The present invention uses gel components such as hyaluronic acid or chitosan and rapamycin to form a composition, which is applied to the damage repair of aging skin. Play a synergistic effect, thereby shortening the onset time and improving the effect of skin repair and anti-aging.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a composition containing rapamycin and its application. Background technique [0002] Rapamycin is a secondary metabolite secreted by soil Streptomyces first discovered by scientists in the soil of Easter Island, Chile in 1975. The drug is named after the name of the island where it was discovered, Rapa Nui. The researchers found that the drug has multiple effects on the human body: it was discovered in 1977 that it has an immunosuppressive effect. In 1989, RAPA was used as a new drug for the treatment of organ transplant rejection. From the results of animal experiments and clinical applications, it is a kind of A new immunosuppressant with good curative effect, low toxicity and no nephrotoxicity. It is now often used as a drug to maintain the immunity of transplanted organs (especially kidney transplantation) to slow down immune rejection after organ transplantation. [0003] Skin ag...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/436A61K31/728A61K31/722A61P17/00A61P17/18A61K8/49A61K8/73A61Q19/00A61Q19/08
CPCA61K8/498A61K8/735A61K8/736A61K31/436A61K31/722A61K31/728A61Q19/00A61Q19/08A61P17/00A61P17/18A61K2300/00
Inventor 单乐天
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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